Doublecortin-like kinase 2 promotes breast cancer cell invasion and metastasis

He, Yan-Ling; Dai, Xiaoqin; Li, Shengnan; Zhang, Mengjie; Gong, Kunxiang; Song, Kai; Shi, Jian

doi:10.1007/s12094-022-03018-z

Cited by 4 publications

(1 citation statement)

References 35 publications

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“…DCLK1 has been identified as a cancer stem cell marker in gastrointestinal, pancreatic, and colorectal cancers, and its overexpression has been associated with tumor progression and poor clinical outcomes in several cancer types [84]. DCLK2 and DCLK3 are also associated with tumor invasion and metastasis in breast cancer and gastric cancer, respectively [85,86]. Several studies show DCLK1 overexpression in head and neck cancer, suggesting DCX superfamily-related neurogenesis as a potential mechanism of intra-tumoral neural infiltration [87][88][89].…”

Section: Neurogenesismentioning

confidence: 99%

Tumor Neurobiology in the Pathogenesis and Therapy of Head and Neck Cancer

Liang,

Hess

2024

Cells

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The neurobiology of tumors has attracted considerable interest from clinicians and scientists and has become a multidisciplinary area of research. Neural components not only interact with tumor cells but also influence other elements within the TME, such as immune cells and vascular components, forming a polygonal relationship to synergistically facilitate tumor growth and progression. This review comprehensively summarizes the current state of the knowledge on nerve–tumor crosstalk in head and neck cancer and discusses the potential underlying mechanisms. Several mechanisms facilitating nerve–tumor crosstalk are covered, such as perineural invasion, axonogenesis, neurogenesis, neural reprogramming, and transdifferentiation, and the reciprocal interactions between the nervous and immune systems in the TME are also discussed in this review. Further understanding of the nerve–tumor crosstalk in the TME of head and neck cancer may provide new nerve-targeted treatment options and help improve clinical outcomes for patients.

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