2011
DOI: 10.1111/j.1525-142x.2011.00465.x
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Doublecortin is expressed in trigeminal motoneurons that innervate the velar musculature of lampreys: considerations on the evolution and development of the trigeminal system

Abstract: Studies in lampreys have revealed interesting aspects of the evolution of the trigeminal system and the jaw. In the present study, we found a marker that distinguishes subpopulations of trigeminal motoneurons innervating two different kinds of oropharyngeal muscles. Immunofluorescence with an antibody against doublecortin (DCX; a neuron-specific phosphoprotein) enabled identification of the trigeminal motoneurons that innervate the velar musculature of larval and recently transformed sea lampreys. DCX-immunore… Show more

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Cited by 5 publications
(4 citation statements)
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References 51 publications
(78 reference statements)
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“…The heterotopy theory and the neoclassical theory of Mallatt (2008) share some similarities, especially in that both assume the involvement of premandibular structures in the ancestral oral apparatus, both propose a posteriorly oriented reduction of the oral domain or oral cavity during the establishment of the gnathostome jaw, and both recognize the premandibular origin of the lamprey upper lip. The two theories also agree with each other in how they interpret the innervation patterns of the trigeminal nerves and the distribution of the mandibular arch-derived muscles (Mallatt 1996(Mallatt , 2008Kuratani et al 1997b;Murakami et al 2004; also see Hatschek 1892;Alcock 1898;von Kupffer 1900;Johnston 1905;Damas 1944;Lindström 1949;Whiting 1977;Barreiro-Iglesias et al 2011 for cranial nerves in cyclostomes). However, based only on the anatomy of larval and adult animals, the neoclassical theory does not homologize the lamprey upper lip with the gnathostome trabecula (as the heterotopy theory does), nor does it explain the difference in positions of the nasal and adenohypophyseal placodes, which are only clarified by observing the embryonic distribution patterns of ectomesenchymes at earlier stages, when the overall morphological plans of the lamprey and gnathostomes are most alike (Figs.…”
Section: Heterotopy Theorysupporting
confidence: 57%
“…The heterotopy theory and the neoclassical theory of Mallatt (2008) share some similarities, especially in that both assume the involvement of premandibular structures in the ancestral oral apparatus, both propose a posteriorly oriented reduction of the oral domain or oral cavity during the establishment of the gnathostome jaw, and both recognize the premandibular origin of the lamprey upper lip. The two theories also agree with each other in how they interpret the innervation patterns of the trigeminal nerves and the distribution of the mandibular arch-derived muscles (Mallatt 1996(Mallatt , 2008Kuratani et al 1997b;Murakami et al 2004; also see Hatschek 1892;Alcock 1898;von Kupffer 1900;Johnston 1905;Damas 1944;Lindström 1949;Whiting 1977;Barreiro-Iglesias et al 2011 for cranial nerves in cyclostomes). However, based only on the anatomy of larval and adult animals, the neoclassical theory does not homologize the lamprey upper lip with the gnathostome trabecula (as the heterotopy theory does), nor does it explain the difference in positions of the nasal and adenohypophyseal placodes, which are only clarified by observing the embryonic distribution patterns of ectomesenchymes at earlier stages, when the overall morphological plans of the lamprey and gnathostomes are most alike (Figs.…”
Section: Heterotopy Theorysupporting
confidence: 57%
“…In lamprey, molecular weights of RP1 and RP1L1 proteins are about 240 and 200 kDa, respectively (Yamashita et al, 2009 ). However, our previous western blot results in lamprey with the present DCX antibody (Barreiro-Iglesias et al, 2011 ) indicate that no protein of these molecular weights is recognized by the anti-DCX antibody used in this study. The expression of DCX in photoreceptors could be a specialization of lampreys or the ancestral character that was lost in jawed vertebrates.…”
Section: Discussioncontrasting
confidence: 54%
“…Two bands of about around 45 kDa (DCX molecular weight) were observed, which were interpreted as a posttranscriptional modification of DCX (Francis et al, 1999 ). Western blots carried out with brain protein extracts of sea lampreys, have also shown two bands around 45 kDa (Barreiro-Iglesias et al, 2011 ).…”
Section: Methodsmentioning
confidence: 99%
“…The evolution of UNC5 receptors is poorly understood, because, whereas at least four members of the UNC5 family are found in jawed vertebrate species, only one UNC5 receptor has been found in invertebrates (see above). Lampreys, together with mixynes, belong to the oldest branch of extant vertebrates, and they are thought to be the closest living forms to early vertebrates, which makes them key animals in comparative and evolutionary studies of the nervous system (Barreiro‐Iglesias et al,2009, 2010b, 2011). The identification and cloning of the UNC5 receptors in lampreys might provide valuable information for our understanding of the early evolution of this axonal guidance system in vertebrates and to know when the duplication/s of the ancestral UNC5 gene took place.…”
mentioning
confidence: 99%