“…In contrast, following seizure activity BrdU+ cells were found extensively in the dentate hilus and/or dentate molecular layer of the hippocampus, indicating aberrant migration of dividing cells in response to seizure-induced cell loss (Parent, et al, 1997, Scharfman, et al, 2000, Scharfman, et al, 2002, Parent, et al, 2006. Similarly, displaced granule cells have been observed in hippocampal tissues obtained from patients with TLE (Houser, 1990, Thom, et al, 2002, Liu, et al, 2008. This suggests that acute seizure-induced dentate gyrus neurogenesis promotes aberrant circuitry development, which likely contributes to the evolution of initial seizure-induced hippocampal injury into chronic epilepsy (Kuruba, et al, 2009).…”