Double-tuned Radiofrequency Coil for 19F and 1H Imaging

Otake, Yosuke; Soutome, Y.; Hirata, Koji; Ochi, Hiroki; Bito, Yoshitaka

doi:10.2463/mrms.2013-0094

Cited by 10 publications

(2 citation statements)

References 12 publications

(13 reference statements)

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“…This immobilized fluorine (<10 -6 M) has only a very short T 2 relaxation as they are in the solid-state and cannot be detected by 19 F MRI (that is below the detection limit), which extinguishes the possibility of intrinsic background signals, implying potentially high SNR [44]. Using the same scanner and the receiver electronics of 1 HMRI with retuned radiofrequency coils/dual-tuned coils, 19 F-images can be superimposed on anatomical, high-resolution 1 H images, generating hotspot 19 F-images (hybrid 1 H/ 19 F MRI) [45][46][47]. The MR effect of the additional element ( 19 F here) does not disturb the local magnetic field either and adds a second colored layer of complementary information to the corresponding grayscale 1 H image, hence called "hot spot" [48,49].…”

Section: Fluorine As a Contrast Agentmentioning

confidence: 99%

Nanotechnology as a Versatile Tool for 19F-MRI Agent’s Formulation: A Glimpse into the Use of Perfluorinated and Fluorinated Compounds in Nanoparticles

et al. 2022

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Simultaneously being a non-radiative and non-invasive technique makes magnetic resonance imaging (MRI) one of the highly sought imaging techniques for the early diagnosis and treatment of diseases. Despite more than four decades of research on finding a suitable imaging agent from fluorine for clinical applications, it still lingers as a challenge to get the regulatory approval compared to its hydrogen counterpart. The pertinent hurdle is the simultaneous intrinsic hydrophobicity and lipophobicity of fluorine and its derivatives that make them insoluble in any liquids, strongly limiting their application in areas such as targeted delivery. A blossoming technique to circumvent the unfavorable physicochemical characteristics of perfluorocarbon compounds (PFCs) and guarantee a high local concentration of fluorine in the desired body part is to encapsulate them in nanosystems. In this review, we will be emphasizing different types of nanocarrier systems studied to encapsulate various PFCs and fluorinated compounds, headway to be applied as a contrast agent (CA) in fluorine-19 MRI (19F MRI). We would also scrutinize, especially from studies over the last decade, the different types of PFCs and their specific applications and limitations concerning the nanoparticle (NP) system used to encapsulate them. A critical evaluation for future opportunities would be speculated.

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Section: Fluorine As a Contrast Agentmentioning

confidence: 99%

Nanotechnology as a Versatile Tool for 19F-MRI Agent’s Formulation: A Glimpse into the Use of Perfluorinated and Fluorinated Compounds in Nanoparticles

et al. 2022

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“…As the signal-to-noise ratio (SNR) can be maximized by tuning the frequency to either 19 F or 1 H, this combined approach has significantly improved 19 F imaging technology. 30 , 31 Villavalverde et al designed a multi-tuned RF coil based on the high B 1 homogeneity of birdcage coils to obtain high-quality images with good uniformity and sensitivity for 19 F. 32 Another study showed that the birdcage coil increased the B 1 homogeneity, which allowed estimation of the minimum detectable 19 F atoms number and 19 F content of the NP. The minimum detectable PLGA-PFCE concentration was 2.5 mg/mL using the birdcage coil in NP solution phantoms imaging and MRS.…”

Section: F Mri Techniquesmentioning

confidence: 99%

<p>Perfluorocarbons-Based <sup>19</sup>F Magnetic Resonance Imaging in Biomedicine</p>

Liu

et al. 2020

IJN

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Fluorine-19 (19 F) magnetic resonance (MR) molecular imaging is a promising noninvasive and quantitative molecular imaging approach with intensive research due to the high sensitivity and low endogenous background signal of the 19 F atom in vivo. Perfluorocarbons (PFCs) have been used as blood substitutes since 1970s. More recently, a variety of PFC nanoparticles have been designed for the detection and imaging of physiological and pathological changes. These molecular imaging probes have been developed to label cells, target specific epitopes in tumors, monitor the prognosis and therapy efficacy and quantitate characterization of tumors and changes in tumor microenvironment noninvasively, therefore, significantly improving the prognosis and therapy efficacy. Herein, we discuss the recent development and applications of 19 F MR techniques with PFC nanoparticles in biomedicine, with particular emphasis on ligand-targeted and quantitative 19 F MR imaging approaches for tumor detection, oxygenation measurement, smart stimulus response and therapy efficacy monitoring, et al.

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19F Magnetic Resonance Imaging and Spectroscopy in Neuroscience

Modo

2021

Neuroscience

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Double-tuned Radiofrequency Coil for 19F and 1H Imaging

Cited by 10 publications

References 12 publications

Nanotechnology as a Versatile Tool for 19F-MRI Agent’s Formulation: A Glimpse into the Use of Perfluorinated and Fluorinated Compounds in Nanoparticles

Nanotechnology as a Versatile Tool for 19F-MRI Agent’s Formulation: A Glimpse into the Use of Perfluorinated and Fluorinated Compounds in Nanoparticles

<p>Perfluorocarbons-Based <sup>19</sup>F Magnetic Resonance Imaging in Biomedicine</p>

19F Magnetic Resonance Imaging and Spectroscopy in Neuroscience

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