Double Switch Biodegradable Porous Hollow Trinickel Monophosphide Nanospheres for Multimodal Imaging Guided Photothermal Therapy

Abstract

Due to the limitation of inorganic nanomaterials in present clinical applications induced by their inherent nonbiodegradability and latent long-term side effects, we successfully prepared double switch degradable and clearable trinickel monophosphide porous hollow nanospheres (NiP PHNPs) modified with bovine serum albumin (BSA). Attributed to their acidic and oxidative double switch degradation capacities, NiP PHNPs can be effectively excreted from mice without long-term toxicity. Moreover, because of the paramagnetic and high molar extinction coefficient property resulting from the strong absorption in the second near-infrared light (NIR II) biowindow, NiP PHNPs have potential to be used for photoacoustic imaging (PAI) and T 1 -weighted magnetic resonance imaging (MRI) guided photothermal ablation of tumors in the NIR II biowindow. Specifically, it is interesting that the hollow structure and acidic degradation property enable NiP PHNPs to act as intelligent drug carriers with an on-demand release ability. These findings highlight the great potential of NiP PHNPs in the cancer theranostics field and inspire us to further broaden the bioapplications of transition metal phosphides.

Renal‐Clearable Nickel‐Doped Carbon Dots with Boosted Photothermal Conversion Efficiency for Multimodal Imaging‐Guided Cancer Therapy in the Second Near‐Infrared Biowindow

“…[ 2 ] Similar to X‐ray and microwave having deeper penetration capacity, [ 3 ] the second‐infrared (NIR‐II, 1000–1350 nm) light has a deeper tissue penetration depth and larger laser maximum permissible exposure (e.g., 1064 nm, 1.0 W cm −2 ) compared to the NIR‐I light (e.g., 808 nm, 0.3 W cm −2 ). [ 4 ] Thus, the development of PTAs with considerable absorption in the NIR‐II region is expected to overcome this dilemma.…”

Plasmonic Pt Superstructures with Boosted Near‐Infrared Absorption and Photothermal Conversion Efficiency in the Second Biowindow for Cancer Therapy

“…Meanwhile, the major organs (including heart, liver, spleen, lung, and kidney) and tumors are collected at various times post injection (Figure d). The results show that Pt Spirals mainly accumulate in the liver, matching the approach of the mononuclear phagocyte system, and accumulate by the tumor cells through the enhanced permeability and retention . The analysis also reveals that the accumulation of Pt Spirals in tumors reaches a maximum at 24 h post injection, providing more information for the optimal treatment time.…”

Energy‐converting biomaterials for cancer therapy: Category, efficiency, and biosafety

“…Consequently, FP completely ablated the tumor cells under 1,064‐nm laser irradiation. Additionally, they also (Liu, Zhen, et al, 2019a; Liu, Zhen, et al, 2019b) successfully developed degradable and clearable tri‐nickel monophosphide (NiP) biomaterials (Figure 5d). NiP showed intriguing photothermal performance due to the strong absorbance in NIR‐II biowindow.…”

“…A similar phenomenon and principle were also reported by the other groups. For instance, Liu et al (2019b) prepared a highly efficient copper(I) phosphide biomaterials (CP) for GSH‐activated and photothermal‐enhanced CDT (Figure 4f). In this nanosystem, the excessive GSH facilitated the Cu + overproduction by the aforementioned mechanism, resulting in improving • OH level in tumor cells by Fenton‐like reaction.…”