Double‐stranded RNA induces S100 gene expression by a cycloheximide‐sensitive factor

Voß, Andreas; Gescher, Kirsten; Hensel, Andreas; Nacken, Wolfgang; Zänker, Kurt S.; Kerkhoff, Claus

doi:10.1016/j.febslet.2011.12.022

Cited by 13 publications

(11 citation statements)

References 49 publications

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“…Hence, S100A8/A9 is rather more involved in liver regeneration than in promoting inflammation. Further indirect evidence is given by the observation that S100A8/A9 gene expression is induced in virus-infected keratinocytes via TLR3 ligation (152). …”

Section: Resultsmentioning

confidence: 99%

S100 Proteins as Diagnostic and Prognostic Markers in Colorectal and Hepatocellular Carcinoma

Maletzki

Bodammer

Breitrück³

et al. 2012

Hepat Mon

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ContextClinical and experimental studies have suggested a link between S100 gene expression and neoplastic disorders, however, the molecular mechanisms of this association are not well understood. The aim of this review was to conduct a comprehensive literature search in order to understand the possible underlying molecular mechanisms of this association. We also discuss their application as diagnostic and prognostic markers in colorectal and hepatocellular carcinoma.Evidence AcquisitionsWe searched Pubmed (NLM) and Web of Science (ISI Web of Knowledge).ResultsS100 genes display a complex expression pattern in colorectal and hepatocel lular carcinoma. They are expressed in tumor and/or tumor stroma cells, and they exert both pro- and antitumorigenic actions. In view of this complexity, it becomes clear that S100 proteins might act as both friend and foe. The biological role of the S100 genes is predicted to depend on the relative contributions of the different cell types at specific stages of tumor progression.ConclusionsFurther research is required in order to uncover the functional role of S100 genes in tumorigenesis. Answers to this issue are needed before we can more fully understand the clinical relevance of S100 protein expression within epithelial tumors, with regard to their potential applicability as biomarkers for diagnosis and therapy decisions.

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Section: Resultsmentioning

confidence: 99%

S100 Proteins as Diagnostic and Prognostic Markers in Colorectal and Hepatocellular Carcinoma

Maletzki

Bodammer

Breitrück³

et al. 2012

Hepat Mon

Self Cite

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“…It is well-known that calcium plays an important role in the formation of the cornfield envelop and stratum corneum barrier by inducing the terminal differentiation of keratinocytes (Watt, 1989;Nemes et al, 1999). As calcium binding protein, S100A family proteins have been shown to be induced by calcium and then regulate cell differentiation during tissue remodeling and repair (Hoffmann et al, 1994;Voss et al, 2011Voss et al, , 2012. However, the underlying mechanism was not fully understood.…”

Section: Discussionmentioning

confidence: 99%

TLR3 activation induces S100A7 to regulate keratinocyte differentiation after skin injury

Wang

Zhang

et al. 2016

Sci. China Life Sci.

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Human S100A7 (psoriasin) is highly expressed in psoriasis and other inflammatory diseases; however, the function of S100A7 in wound repair remains largely unknown. Here we demonstrated that skin injury increased the expression of S100A7. Damaged cells from wounded skin induced the expression of S100A7 via the activation of Toll-like receptor 3 (TLR3) followed by the activation of p38 MAPK. S100A7, in turn, acted on keratinocytes to induce the expression of terminal differentiation marker gene loricrin through the activation of p38 MAPK and caspase-1. The differentiation of keratinocytes induced by S100A7 resulted in skin stratification, thus efficiently promoting wound closure. Taken together, our results demonstrate that the activation of TLR3 accelerates wound closure via the induction of S100A7 to induce keratinocyte differentiation. These findings also provide new insights into the development of different forms of treatment with skin wounds.

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“…Additionally, the inhibition of endogenous HSP70 and HSP90 can attenuate PRRSV replication Gao et al, 2014); however, there are few reports investigating the role of S100A9 in viral infection. Some previous studies indicate that S100A9 could be induced by poly I:C stimulation (Voss et al, 2012), and human papillomavirus infection also increases S100A9 production (Tugizov et al, 2005). Similarly, the level of S100A9 in patients infected with coronavirus was also upregulated by more than 60-fold (Reghunathan et al, 2005).…”

Section: Discussionmentioning

confidence: 92%

S100A9 regulates porcine reproductive and respiratory syndrome virus replication by interacting with the viral nucleocapsid protein

Song

Bai

Liu

et al. 2019

Veterinary Microbiology

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Porcine reproductive and respiratory syndrome virus (PRRSV) has caused huge economic losses to the pig industry worldwide over the last 30 years, yet the associated viral-host interactions remain poorly understood. S100A9 is a damage-associated molecular pattern of the S100 protein family. Here, we found that PRRSV infection stimulated S100A9 expression in porcine alveolar macrophages (PAMs) and Marc-145 cells. S100A9 inhibited PRRSV replication via cellular Ca 2+ dependent manner. The viral nucleocapsid (N) protein co-localized with S100A9 in the cytoplasm, and directly interacted at amino acid 78 of S100A9 and amino acids 36-37 of N protein. Moreover, we also found that the mutant S100A9 (E78Q) protein exhibited decreased antiviral activity against PRRSV compared with the parent S100A9. Recombinant PRRSV rBB (36/37) with two mutations in amino acid 36-37 in the N protein exhibited greater replication than the parent PRRSV BB0907 in S100A9overexpressed PAM and Marc-145 cells. Thus, S100A9 may restrict PRRSV proliferation by interacting with the viral N protein.

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Double‐stranded RNA induces S100 gene expression by a cycloheximide‐sensitive factor

Cited by 13 publications

References 49 publications

S100 Proteins as Diagnostic and Prognostic Markers in Colorectal and Hepatocellular Carcinoma

S100 Proteins as Diagnostic and Prognostic Markers in Colorectal and Hepatocellular Carcinoma

TLR3 activation induces S100A7 to regulate keratinocyte differentiation after skin injury

S100A9 regulates porcine reproductive and respiratory syndrome virus replication by interacting with the viral nucleocapsid protein

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