“…ADAR1 limits or controls replication of several viruses, including measles virus, members of Paramyxoviridae family, IAV, HIV-1, vesicular stomatitis virus, and hepatitis delta virus ( Casey, 2012 ; Li et al., 2010 ; Vogel et al., 2020 ; Ward et al., 2011 ; Weiden et al., 2014 ). However, for other viruses, such as Zika and Kaposi's sarcoma-associated herpesvirus, ADAR1 may facilitate replication ( Zhang et al., 2020a ; Zhou et al., 2019 ). It will be interesting for future studies to determine the role of the ADAR1 variants unable to bind Z nucleic acids in these viral infections.…”