Abstract:The interactions
of luteolin (Lut) with bovine serum albumin (BSA)
mediated by Cu(II) were investigated by spectroscopic, calorimetric,
and molecular dynamic (MD) methods. Fluorescence studies showed that
the binding of Lut to BSA was significantly enhanced by Cu(II) coordination
with the number of binding sites and binding constant increasing from
n
= 1 and
K
a
= 3.2 × 10
5
L·mol
–1
for Lut to
… Show more
Two bis-Schiff base metal(ii) complexes [Cu(L)2](1) and [Ni(L)2](2) were designed and synthesized as potential inhibitors for the development of new anti-SARS-CoV-2 Omicron and anti-HIV drugs.
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