Double-sided electrohydrodynamic jet printing of two-dimensional electrode array in paper-based digital microfluidics

Jafry, Ali Turab; Lee, Hyungdong; Tenggara, Ayodya Pradhipta; Lim, Hosub; Moon, Youngkwang; Kim, Seung Hyun; Lee, Yong-Woo; Kim, Sung-Min; Park, Sungsu; Byun, Doyoung; Lee, Jinkee

doi:10.1016/j.snb.2018.11.135

Cited by 43 publications

(27 citation statements)

References 32 publications

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“…Jafry et al demonstrated a novel p-DMF chip based on double-sided electrohydrodynamic jet printing of circuitry and the dispensing of high-viscosity silver nanoparticles as a two-dimensional array of electrodes on a single paper sheet. The proposed p-DMF device effectively performed as a low-cost, disposable POCT platform for pesticide detection ( Figure 6 ) [ 82 ]. The p-DMF platform could be operated with a low operating voltage to move the droplet toward an actuated electrode; such a low operating voltage would not be harmful to bioassays and would be appropriate for portable POCT applications.…”

Section: Detection Techniquesmentioning

confidence: 99%

“…Thus, devices that allow on-site detection and accurate monitoring of environmental conditions are needed. μPADs have been developed to improve the accuracy and performance for multiplexed colorimetric detection of pesticides [ 82 ] and heavy metals in the air [ 158 ] and rivers [ 189 , 190 ]. The devices developed thus far are portable and can be used as rapid on-site monitoring platforms for the detection of multiple heavy-metal ions; they have a wide linear range and a low detection limit down to the microgram level.…”

Section: Applications Of µPadsmentioning

confidence: 99%

“… ( a ) Schematic illustration of the fabrication of two-dimensional electrode arrays for a p-DMF device, ( b ) photograph of the printed p-DMF device showing the 3D circuitry over an LED lamp, ( c ) the p-DMF device showing merging, mixing, and transport functions. Reproduced with permission from the authors of [ 82 ]. Copyright 2018, Elsevier B.V. …”

Section: Figurementioning

confidence: 99%

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Recent Advances in Microfluidic Paper-Based Analytical Devices toward High-Throughput Screening

et al. 2020

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Microfluidic paper-based analytical devices (µPADs) have become promising tools offering various analytical applications for chemical and biological assays at the point-of-care (POC). Compared to traditional microfluidic devices, µPADs offer notable advantages; they are cost-effective, easily fabricated, disposable, and portable. Because of our better understanding and advanced engineering of µPADs, multistep assays, high detection sensitivity, and rapid result readout have become possible, and recently developed µPADs have gained extensive interest in parallel analyses to detect biomarkers of interest. In this review, we focus on recent developments in order to achieve µPADs with high-throughput capability. We discuss existing fabrication techniques and designs, and we introduce and discuss current detection methods and their applications to multiplexed detection assays in relation to clinical diagnosis, drug analysis and screening, environmental monitoring, and food and beverage quality control. A summary with future perspectives for µPADs is also presented.

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Section: Detection Techniquesmentioning

confidence: 99%

Section: Applications Of µPadsmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

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Recent Advances in Microfluidic Paper-Based Analytical Devices toward High-Throughput Screening

et al. 2020

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“…Chemical vapor deposition (CVD) [3,4,28] Parylene-C/Teflon High quality coating; controllable coating thickness Requires clean room facilities; expensive Spin coating [68] Polydimethylsiloxane (PDMS)/silicon oil Simple process Difficult to coat large area; excessive material waste…”

Section: Dielectric-hydrophobic Layermentioning

confidence: 99%

“…When the symmetry of a wetted droplet is broken, it can be moved to a higher wetting surface by an applied voltage ( Figure 15b). Conventionally, when the electrical power applied to operate a p-DMF device is switched on or off, the switch is operated manually or by using the LabVIEW or the MATLAB software [3,68]. When programmable software is used, the handling of the fluid droplets on a p-DMF device is much easier to control than it is when manual switching is used.…”

Section: Droplet Manipulations In P-dmf Devicesmentioning

confidence: 99%

Micro- and Nanofluidics for Bionanoparticle Analysis

Zeng¹,

Cheng²

2019

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of Surgery at Massachusetts General Hospital. The focus of her research is to develop microfluidic devices for cell and pathogen analysis. In combination with nanomaterials and biosensors, these microfluidic devices are expected to perform automated sample processing and sensitive analyte detection towards point-of-care uses. She has published more than 60 referred technical papers, has been granted several U.S. patents and has obtained research funding from NIH, NSF, and DoD.Yong Zeng currently is a Docking Scholar Associate Professor in the

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Recent Advances on Cell Culture Platforms for In Vitro Drug Screening and Cell Therapies: From Conventional to Microfluidic Strategies

Cardoso

Castanheira

Lanceros‐Méndez

et al. 2023

Adv Healthcare Materials

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The clinical translations of drugs and nanomedicines depend on coherent pharmaceutical research based on biologically accurate screening approaches. Since establishing the 2D in vitro cell culture method, the scientific community has improved cell-based drug screening assays and models. Those advances result in more informative biochemical assays and the development of 3D multicellular models to describe the biological complexity better and enhance the simulation of the in vivo microenvironment. Despite the overall dominance of conventional 2D and 3D cell macroscopic culture methods, they present physicochemical and operational challenges that impair the scale-up of drug screening by not allowing a high parallelization, multidrug combination, and high-throughput screening. Their combination and complementarity with microfluidic platforms enable the development of microfluidics-based cell culture platforms with unequivocal advantages in drug screening and cell therapies. Thus, this review presents an updated and consolidated view of cell culture miniaturization's physical, chemical, and operational considerations in the pharmaceutical research scenario. It clarifies advances in the field using gradient-based microfluidics, droplet-based microfluidics, printed-based microfluidics, digital-based microfluidics, SlipChip, and paper-based microfluidics. Finally, it presents a comparative analysis of the performance of cell-based methods in life research and development to achieve increased precision in the drug screening process.

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Double-sided electrohydrodynamic jet printing of two-dimensional electrode array in paper-based digital microfluidics

Cited by 43 publications

References 32 publications

Recent Advances in Microfluidic Paper-Based Analytical Devices toward High-Throughput Screening

Recent Advances in Microfluidic Paper-Based Analytical Devices toward High-Throughput Screening

Micro- and Nanofluidics for Bionanoparticle Analysis

Recent Advances on Cell Culture Platforms for In Vitro Drug Screening and Cell Therapies: From Conventional to Microfluidic Strategies

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