Double saccadic pulses and macrosaccadic oscillations from a focal brainstem lesion

Kim, Ji Soo; Choi, Kyeongdal; Oh, Sun Young; Jeong, Seong-Hae; Oh, Young Mi; Kim, Hyo Jung; Ahn, Jin Young

doi:10.1016/j.jns.2007.07.003

Cited by 16 publications

(7 citation statements)

References 23 publications

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“…Comment: Single saccadic pulses are followed by a drift back to the original position, suggesting absence of a step signal (pulse-step mismatch) [102]. Double saccadic pulses consist of an initial saccade away from fixation followed immediately by a return saccade back to fixation [7,94]. Saccadic pulses may sometimes occur in a series or alternate directions.…”

Section: 23)mentioning

confidence: 99%

Classification of vestibular signs and examination techniques: Nystagmus and nystagmus-like movements

Eggers

Bisdorff

Brevern

et al. 2019

VES

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This paper presents a classification and definitions for types of nystagmus and other oscillatory eye movements relevant to evaluation of patients with vestibular and neurological disorders, formulated by the Classification Committee of the Bárány Society, to facilitate identification and communication for research and clinical care. Terminology surrounding the numerous attributes and influencing factors necessary to characterize nystagmus are outlined and defined. The classification first organizes the complex nomenclature of nystagmus around phenomenology, while also considering knowledge of anatomy, pathophysiology, and etiology. Nystagmus is distinguished from various other nystagmus-like movements including saccadic intrusions and oscillations.

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Section: 23)mentioning

confidence: 99%

Classification of vestibular signs and examination techniques: Nystagmus and nystagmus-like movements

Eggers

Bisdorff

Brevern

et al. 2019

VES

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“…Ataxia results from dysfunction of the cerebellum, or cerebellar inflow / outflow tracts within the pons, midbrain, and thalamus. Opsoclonus is thought to originate from either the cerebellum (Wong et al, 2001) or dysfunction of omnipause neurons in the pons (Kim et al, 2007; Ramat et al, 2008). As there is a minimal brain inflammation in OMAS (Kilgo and Schwartze, 1984), autoantibodies in OMAS may directly bind to their target antigen, disrupting its function without causing significant inflammatory tissue destruction, analogous to what is seen in encephalidities associated with known neuronal surface antigens (Bien et al, 2012; Dalmau et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Antibodies to dendritic neuronal surface antigens in opsoclonus myoclonus ataxia syndrome

Panzer

Anand

Dalmau

et al. 2015

Journal of Neuroimmunology

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Opsoclonus myoclonus ataxia syndrome (OMAS) is an autoimmune disorder characterized by rapid, random, conjugate eye movements (opsoclonus), myoclonus, and ataxia. Given these symptoms, autoantibodies targeting the cerebellum or brainstem could mediate the disease or be markers of autoimmunity. In a subset of patients with OMAS, we identified such autoantibodies, which bind to non-synaptic puncta on the surface of live cultured cerebellar and brainstem neuronal dendrites. These findings implicate autoimmunity to a neuronal surface antigen in the pathophysiology of OMAS. Identification of the targeted antigen(s) could elucidate the mechanisms underlying OMAS and provide a biomarker for diagnosis and response to therapy.

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“…Macrosaccadic oscillations are most frequently observed in human patients with destructive lesions affecting the cerebellar nuclei, 2 but they have also been described in association with hereditary cerebellar ataxias 19 and rarely after lesions to certain pontine structures. 20,21 The Dachshund with suspected macrosaccadic oscillations in our study (Case 4) was diagnosed with NCL and had both clinical signs and MRI changes consistent with cerebellar disease. Given the association between this type of eye movement and cerebellar disease in humans, we suspect the Dachshund's ocular signs resulted from cerebellar degeneration, but lesions involving the retina or other regions of the brain affected by NCL could have also been responsible.…”

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confidence: 79%

“…However, a further description of these eye movements is not provided to enable comparison to those described in human medicine. Macrosaccadic oscillations are most frequently observed in human patients with destructive lesions affecting the cerebellar nuclei, but they have also been described in association with hereditary cerebellar ataxias and rarely after lesions to certain pontine structures . The Dachshund with suspected macrosaccadic oscillations in our study (Case 4) was diagnosed with NCL and had both clinical signs and MRI changes consistent with cerebellar disease.…”

Section: Discussionmentioning

confidence: 99%

Saccadic oscillations in 4 dogs and 1 cat

Ives¹,

Mackillop²,

Olby

2018

Veterinary Internal Medicne

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Disorders affecting the control of saccadic eye movements result in involuntary saccadic oscillations and are widely reported in human medicine. Information regarding the occurrence and potential importance of saccadic oscillations in veterinary medicine is currently limited. The clinical histories of three dogs and one cat displaying involuntary eye movements consistent with opsoclonus are presented, with final diagnoses including idiopathic generalized tremor syndrome and neuronal ceroid lipofuscinosis (NCL). A dog with eye movements closely resembling macrosaccadic oscillations is also presented, for which a final diagnosis of NCL was made. All animals had clinical signs of cerebellar disease. As in human medicine, recognition of these forms of involuntary eye movement might suggest a cerebellar neuroanatomic localization. Opsoclonus and macrosaccadic oscillations are forms of involuntary saccadic eye movement that are both unrecognized and under‐reported in veterinary medicine.

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Double saccadic pulses and macrosaccadic oscillations from a focal brainstem lesion

Cited by 16 publications

References 23 publications

Classification of vestibular signs and examination techniques: Nystagmus and nystagmus-like movements

Classification of vestibular signs and examination techniques: Nystagmus and nystagmus-like movements

Antibodies to dendritic neuronal surface antigens in opsoclonus myoclonus ataxia syndrome

Saccadic oscillations in 4 dogs and 1 cat

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