Double Reactivity Against Actin and α-Actinin Defines a Severe Form of Autoimmune Hepatitis Type 1

Guéguen, Paul; Georgios, Dalekos; Jean-Baptiste, Nousbaum; Zachou, Kalliopi; Putterman, Chaim; Pierre, Youinou; Renaudineau, Yves

doi:10.1007/s10875-006-9045-z

Cited by 40 publications

(11 citation statements)

References 34 publications

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“…Anti-actin antibodies have been associated with various autoimmune diseases including systemic lupus erythematosus [29], a disease in which endothelial damage plays a key role. Anti-filamentous actin antibodies characterize autoimmune hepatitis type 1 where the binding domain of α -actinin on actin was shown to be a predominant actin epitope [30]. Anti-actin antibodies were also found in 52–85% of patients with autoimmune hepatitis or chronic active hepatitis, in 22% of patients with primary biliary cirrhosis, and in patients with celiac disease and with autoimmune haemolytic anaemia [31–34].…”

Section: Discussionmentioning

confidence: 99%

Actin Is a Target of T-Cell Reactivity in Patients with Advanced Carotid Atherosclerotic Plaques

Profumo

Buttari

Petrone

et al. 2013

Mediators of Inflammation

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Atherosclerosis is a chronic inflammatory disease of the arterial wall associated with autoimmune reactions. In a previous study, we observed the presence of actin-specific antibodies in sera from patients with carotid atherosclerosis. To extend our previous results we evaluated the possible role of actin as antigenic target of cell-mediated immune reactions in carotid atherosclerosis. Peripheral blood mononuclear cells (PBMC) from 17 patients and 16 healthy subjects were tested by cell proliferation assay and by ELISA for cytokine production. Actin induced a proliferative response in 47% of patients' PBMC samples, with SI ranging from 2.6 to 21.1, and in none of the healthy subjects' samples (patients versus healthy subjects, P = 0.02). The presence of diabetes in patients was significantly associated with proliferative response to actin (P = 0.04). IFN-γ and TNF-α concentrations were higher in PBMC from patients than in those from healthy subjects and in PBMC proliferating to actin than in nonproliferating ones. Our data demonstrate for the first time a role of actin as a target autoantigen of cellular immune reactions in patients with carotid atherosclerosis. The preferential proinflammatory Th1 activation suggests that actin could contribute to endothelial dysfunction, tissue damage, and systemic inflammation in carotid atherosclerosis.

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Section: Discussionmentioning

confidence: 99%

Actin Is a Target of T-Cell Reactivity in Patients with Advanced Carotid Atherosclerotic Plaques

Profumo

Buttari

Petrone

et al. 2013

Mediators of Inflammation

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“…Anti-F-actin are likely to recognize a specific epitope corresponding to the α-actinin-binding domain. Gueguen and colleagues emphasized the importance of analyzing both anti-actin and anti-α-actinin antibodies in patients with type 1 AIH [ 77 ]. One-third of sera with type 1 AIH reacted simultaneously with anti-F-actin and anti-α-actinin.…”

Section: Diagnostic and Prognostic Values Of Autoantibodies In Liver mentioning

confidence: 99%

“…One-third of sera with type 1 AIH reacted simultaneously with anti-F-actin and anti-α-actinin. Moreover, antibodies to α-actinin were frequently associated with antibodies to single stranded DNA [ 77 , 78 ].…”

Section: Diagnostic and Prognostic Values Of Autoantibodies In Liver mentioning

confidence: 99%

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Autoantibodies in liver disease: important clues for the diagnosis, disease activity and prognosis

Himoto

Nishioka

2013

Autoimmun Highlights

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It has been well established that numerous kinds of autoantibodies have been detected in liver disease. Some kinds of autoantibodies may be helpful in the diagnosis of autoimmune liver diseases including autoimmune hepatitis, primary biliary cirrhosis or primary sclerosing cholangitis. However, these autoantibodies are present even in sera of patients with viral hepatitis, drug-induced hepatitis, alcoholic liver disease, non-alcoholic fatty liver disease and hepatocelluar carcinoma as well as in sera of patients with autoimmune liver diseases. Other kinds of autoantibodies are recognized as predictive hallmarks for disease activity or prognosis in liver diseases. On the other hand, treatment with interferon initiates the production of several types of autoantibodies in patients with chronic hepatitis C virus infection. Some of autoantibodies induced by interferon may postulate the treatment outcome in those patients. Recent studies also revealed the close correlation between oxidative stress and the production of autoantibodies in liver diseases. This article primarily reviews the recent advances of autoantibodies in the liver diseases and discusses the clinical significance of these autoantibodies.

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“…We must admit that, in contrast to the anti-dsDNA/chromatin activity, the results of the detection of these autoAbs are inconsistent [53–56]. Of interesting note, the anti- α -actinin response is related to the actin-binding site of α -actinin [54, 57]. …”

Section: Autoantibodies and Lupus Nephritismentioning

confidence: 99%

Mesangial Cell-Specific Antibodies Are Central to the Pathogenesis of Lupus Nephritis

Séret

Meur

Renaudineau

et al. 2012

Clinical and Developmental Immunology

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Not only is nephritis a common complaint in systemic lupus erythematosus, but it is also the most life-threatening complication of the disease. Anti-double-stranded DNA antibodies (Abs), which are found in up to 80% of these patients, might be nephritogenic per se. That is, they may cross-react with mesangial cell (MC) surface proteins, such as alpha-actinin and annexin A2, they may cross-react with mesangial matrix protein such as laminine and fibronectin, or they may recognize chromatin material previously deposited in the glomeruli. The consequence of the binding of anti-MC Abs may be their internalization, which results in activation and proliferation of these MCs. In turn, these activated MCs are suspected of promoting immune complex formation by sequestering and thereby protecting chromatin from degradation. The present paper will explain the mechanisms through which such autoAbs may initiate nephritis.

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Double Reactivity Against Actin and α-Actinin Defines a Severe Form of Autoimmune Hepatitis Type 1

Cited by 40 publications

References 34 publications

Actin Is a Target of T-Cell Reactivity in Patients with Advanced Carotid Atherosclerotic Plaques

Actin Is a Target of T-Cell Reactivity in Patients with Advanced Carotid Atherosclerotic Plaques

Autoantibodies in liver disease: important clues for the diagnosis, disease activity and prognosis

Mesangial Cell-Specific Antibodies Are Central to the Pathogenesis of Lupus Nephritis

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