Double 
                
$Q^2$
              -rescaling model and the nuclear effect of the parton distribution functions

Zhenmin, He; Yao, Xiaoxia; Duan, Chun-Gui; Li, Guang-Lie; Hong-an, Peng

doi:10.1007/s100529800756

Cited by 4 publications

(3 citation statements)

References 2 publications

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“…[ 24,32 ] The hepatoprotective effects of OA allow its use in China as an over‐the‐counter oral drug for liver disorders such as viral hepatitis in humans. [ 25,33–35 ] A recent study reported that neonatal intake of OA prevented and attenuated the subsequent development of high fructose diet‐induced NAFLD in rats. [ 36 ] We have also shown that OA diminished liquid fructose‐induced fatty liver in rats and demonstrated that OA‐elicited lipid‐lowing action is associated with selective regulation of hepatic SREBP1c‐mediated expression of various genes, including Scd1 , which is responsible for de novo FA synthesis.…”

Section: Introductionmentioning

confidence: 99%

Oleanolic Acid Inhibits SCD1 Gene Expression to Ameliorate Fructose‐Induced Hepatosteatosis through SREBP1c‐Dependent and ‐Independent Mechanisms

Yao

Wang

Zhang

et al. 2023

Molecular Nutrition Food Res

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Scope The mechanisms of oleanolic acid (OA) regulating hepatic sterol regulatory element‐binding protein (SREBP) 1c/stearoyl‐CoA desaturase (SCD) 1 pathway to ameliorate fructose‐induced hepatosteatosis are investigated. Methods and results Rats treated with 10% w/v fructose solution are co‐administered by OA for 5 weeks, and then sacrifice after fasting for 14 h. OA reverses the fructose‐induced increase in hepatic triglyceride (TG) content and downregulates Scd1 mRNA expression. However, two upstream transcription factors, ChREBP and SREBP1c, remain at normal levels with or without fructose and/or OA. In vivo and in vitro studies using SREBP1c−/− mice and HepG2 cell models show that OA also inhibits SCD1 gene overexpression and high hepatic TG levels induced by fructose. On the other hand, in SCD1−/− mice, when the fructose diet is supplemented with high levels of oleic acid (OLA) to compensate for the deficiency of SCD1, OA inhibits hepatic SREBP1c and lipogenic gene expression and reduces hepatic OLA (C18:1) production to improve fructose and/or OLA induced liver lipid deposition. Furthermore, OA promotes PPARα and AMPK to enhance fatty acid oxidation in fructose + OLA‐fed SCD1−/− mice. Conclusion OA may inhibit SCD1 gene expression to ameliorate fructose‐induced hepatosteatosis through SREBP1c‐dependent and ‐independent mechanisms.

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Section: Introductionmentioning

confidence: 99%

Oleanolic Acid Inhibits SCD1 Gene Expression to Ameliorate Fructose‐Induced Hepatosteatosis through SREBP1c‐Dependent and ‐Independent Mechanisms

Yao

Wang

Zhang

et al. 2023

Molecular Nutrition Food Res

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“…It became clear that even in a DIS process characterized by high locality of the probe-target interaction region, a different picture emerges from the nucleus other than a collection of quasi-free nucleons. On the theory side, despite decades of theoretical efforts [2,3,4,5,6] with increased sophistication, a unifying physical picture of the origin of the EMC effect is still a matter of intense debate. To reach the next level of our understanding of nuclear QCD and unravel the partonic structure of nuclei, experiments need to go beyond the inclusive measurements and focus on exclusive and semi-inclusive reactions.…”

Section: Introductionmentioning

confidence: 99%

“…Hard exclusive experiments such as Deep Virtual Compton Scattering (DVCS) and Deep Virtual Meson Production (DVMP) provide an important new probe that will allow us to discern among the different interpretations of nuclear effects on the structure of embedded nucleons in the nuclear medium. By introducing a new framework to describe both the intrinsic motion of partons and their transverse spatial structure in nuclei [4,5,6,7,8,9]. valuable information can be obtained from the measurement of the nuclear Generalized Parton Distributions (GPDs) representing the soft matrix elements for these processes.…”

Section: Introductionmentioning

confidence: 99%

Partonic Structure of Light Nuclei

Armstrong¹,

Arrington²,

Cloët³

et al. 2017

Preprint

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In this run group, we propose a comprehensive physics program to investigate the fundamental structure of the 4 He nucleus. An important focus of this program is on the coherent exclusive Deep Virtual Compton Scattering (DVCS) and Deep Virtual Meson Production (DVMP) with emphasis on φ meson production. These are particularly powerful tools enabling model-independent nuclear 3D tomography through the access of partons' position in the transverse plane. These exclusive measurements will give the chance to compare directly the quark and gluon radii of the helium nucleus. Another important measurement proposed in this program is the study of the partonic structure of bound nucleons. To this end, we propose next generation nuclear measurements in which low energy recoil nuclei are detected. The tagging of recoil nuclei in deep inelastic reactions is a powerful technique, which will provide unique information about the nature of medium modifications through the measurement of the EMC ratio and its dependence on the nucleon off-shellness. Finally, we propose to measure incoherent spectator-tagged DVCS on light nuclei (d, 4 He) where the observables are sensitive to the Generalized Parton Distributions (GPDs) of a quasi-free neutron for the case of the deuteron, and bound proton and neutron for the case of 4 He. The objective is to study and separate nuclear effects and their manifestation in GPDs. The fully exclusive kinematics provide a novel approach for studying final state interactions in the measurements of the beam spin asymmetries and the off-forward EMC ratio.At the heart of this program is the Low Energy Recoil Tracker (ALERT) combined with the CLAS12 detector. The ALERT detector is composed of a stereo drift chamber for track reconstruction and an array of scintillators for particle identification. Coupling these two types of fast detectors will allow ALERT to be included in the trigger for efficient † Contact Person: Kawtar Hafidi

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Quark distributions in nuclei and nuclear effects on nucleon structure functions

et al. 2009

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Double $Q^2$ -rescaling model and the nuclear effect of the parton distribution functions

Cited by 4 publications

References 2 publications

Oleanolic Acid Inhibits SCD1 Gene Expression to Ameliorate Fructose‐Induced Hepatosteatosis through SREBP1c‐Dependent and ‐Independent Mechanisms

Oleanolic Acid Inhibits SCD1 Gene Expression to Ameliorate Fructose‐Induced Hepatosteatosis through SREBP1c‐Dependent and ‐Independent Mechanisms

Partonic Structure of Light Nuclei

Quark distributions in nuclei and nuclear effects on nucleon structure functions

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