Double Primary Cancers: Intrahepatic Cholangiocarcinoma with Myocardial Metastases and Lung Squamous Cell Carcinoma

Abstract

We herein present a rare case of myocardial metastases from intrahepatic cholangiocarcinoma. The patient was a 68-year-old man diagnosed with stage IVb intrahepatic cholangiocarcinoma. Growing low-density nodules at the cardiac interventricular septum and the left lateral wall were found on contrast enhanced computed tomography (CECT). He died and an autopsy was performed. Intrahepatic cholangiocarcinoma was found to have metastasized to the myocardium, and these myocardial metastases conformed to the low-density nodules detected on CECT. A hilar nodule in the lung was revealed to be lung squamous cell carcinoma. This was a rare case of intrahepatic cholangiocarcinoma with myocardial metastases and lung squamous cell carcinoma.

Treating unresectable intrahepatic cholangiocarcinoma with transarterial chemoembolization and an unusual progression with cardiac involvement

“…We only found a few cases of heart metastases from intrahepatic cholangiocarcinoma. [5,12,13] Our patient had a mass infiltrating the myocardium which was protruding into the ventricular cavity. Additionally in our case, there was an insignificant pericardial effusion.…”

An unresectable and metastatic intrahepatic cholangiocarcinoma with EML4-ALK rearrangement achieving partial response after first-line treatment with ensartinib: a case report

“…The incidence of synchronous double primary ICC and another cancer is too low to have sufficient data. Several cases of double primary hepatic cancers with hepatocellular carcinoma and ICC were reported ( 17 – 19 ), but only one case report described double primary cancers with ICC and lung squamous cell carcinoma ( 20 ). Considering the rarity of double primary cancers, we suspected that pulmonary lesions were more likely to be metastatic, but we could not obtain the lung tissue, which is a limitation of this case report.…”