Double-phase 18F-FDG PET-CT for determination of pulmonary tuberculoma activity

Kim, In-Ju; Lee, Jung Sub; Kim, Seong-Jang; Kim, Yong-Ki; Jeong, Yeon Joo; Jun, Sun-Young; Nam, Hyun Yul; Kim, Ju Sung

doi:10.1007/s00259-007-0585-0

Cited by 96 publications

(105 citation statements)

References 16 publications

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“…The few published reports employ [ 18 F]fluoro-2-deoxy-D-glucose (FDG), a relatively nonspecific marker of inflammation, and have emphasized understanding the characteristics of lesions in asymptomatic patients to accurately distinguish tuberculomas from malignancies, driven by the diagnostic dilemma faced by oncologists (17,21,24). A recent study evaluated the ability of maximum standardized uptake value (SUV max ) from [ 18 F]FDG PET to retrospectively distinguish between biopsy-confirmed active and inactive tuberculomas (30). Serial […”

mentioning

confidence: 99%

Infection Dynamics and Response to Chemotherapy in a Rabbit Model of Tuberculosis using [ ¹⁸ F]2-Fluoro-Deoxy- d -Glucose Positron Emission Tomography and Computed Tomography

Via

Schimel

Weiner

et al. 2012

Antimicrob Agents Chemother

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C uring drug-sensitive tuberculosis (TB) takes 6 to 9 months of combination therapy despite the availability of antibiotics with potent in vitro activity, yet other pulmonary infectious diseases can be cured with single drugs that have similar mechanisms of action with only 3 to 14 days of treatment. One hypothesis used to explain the extended duration required with TB therapy is that subpopulations of bacteria become phenotypically drug tolerant in response to specific local microenvironmental conditions determined by the pathology of individual lesions (37). Understanding the features of these microenvironments and the conditions that generate tolerance may allow a rational design of drug regimens capable of shortening the time required to achieve a durable TB cure, but the methods used to evaluate new regimens have changed little and rely heavily on murine models of tuberculosis that typically have less complex lung pathology than human lesions. Premature discontinuation of treatment in humans results in disease relapse and the presence of cavities, and advanced lung pathology is strongly correlated with relapse (7,19,23). Only the rabbit and nonhuman primate models of pulmonary tuberculosis develop similar heterogeneous pathology, including the formation of cavitary disease. Guinea pigs, and some newer mouse models, develop more highly organized lesions, but these do not progress to cavities (for a comprehensive review of the comparative pathology of tuberculosis animal models, see reference 2).Nonterminal monitoring procedures, such as live imaging modalities, are increasingly being applied during TB drug efficacy experiments in animals and in human clinical trials (12,32,40,52). Structural and/or functional features observed in imaging modalities such as computed tomography (CT) and positron emission tomography (PET) are particularly attractive because they can be measured serially in a single subject at many time points during treatment. Computed tomography (CT) can add highly detailed information to the characteristic features of pulmonary tuberculosis visualized using conventional chest X-rays (1). CT scanning is typically used to monitor patients, assist in diagnosis, and assess surgical options for drug-resistant cases of disease (26), but there have been few examinations of the rate of change in CT findings during chemotherapy. The most detailed study of TB chemotherapy in patients (25) examined high-resolution CT scans from patients undergoing TB chemotherapy for up to 20 months. Old fibrotic lesions could be distinguished from active lesions, and criteria for the state of metabolic activity of lesions were proposed. However, that study did not sequentially

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confidence: 99%

Infection Dynamics and Response to Chemotherapy in a Rabbit Model of Tuberculosis using [ ¹⁸ F]2-Fluoro-Deoxy- d -Glucose Positron Emission Tomography and Computed Tomography

Via

Schimel

Weiner

et al. 2012

Antimicrob Agents Chemother

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“…mean standardized uptake value), obliczający średnią wartość wychwytu w całym obszarze zainteresowania ROI lub VOI (ang. region of interest; volume of interest) [14][15][16][17][18]. Często stosowanym punktem odcięcia wartości SUVmax oznaczającym potencjalnie wysokie ryzyko złośliwości jest wartość SUVmax=2.5 [11,[19][20], jednakże liczni badacze wskazują, że oznaczanie takiego poziomu SUV może okazać się niewystarczające z uwagi na obserwowany czasami względnie wysoki stopień utylizacji glukozy przez zmiany o charakterze zapalnym (np.…”

Section: Wstępunclassified

“…Otrzymany spadek w strukturach fizjologicznych oraz wzrost w obrębie zmian łagodnych oraz zmian złośliwych wskazuje jednakże na konieczność pogłębienia analizy celem wyznaczenia właściwego punktu odcięcia wartości SUVmax 90 minut po iniekcji radiofarmaceutyku. Z danych literaturowych wynika, że wzrastająca w czasie retencja znacznika w obszarze zmian łagodnych utrudnia diagnostykę różnicową, podnosząc średnią wartość parametru SUV w stosunku do reszty analizowanych obszarów [14][15][20][21][22][23].…”

Section: Dyskusjaunclassified

Ocena przydatności badań opóźnionych 18F-FDG PET/CT w różnicowaniu zmian łagodnych i złośliwych

Pietrzak

Smoleń

Cholewiński

2017

los

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StreszczenieCelem pracy była ocena użyteczności badań opóźnionych w diagnostyce różnicowej zmian łagodnych i złośliwych regionu głowy i szyi. 27 mężczyzn (średnia wieku: 62±4 lata, przedział wiekowy: 54-67 lata) poddano badaniom dwufazowym pozytonowej tomografii emisyjnej/tomografii komputerowej z użyciem radiofarmaceutyku fluoro-18-deoksyglukoza ( 18 F-FDG-PET/CT). We wszystkich przypadkach analizowano struktury fizjologiczne nieobjęte procesem złośliwym (łącznie 207), zmiany złośliwe (41 guzów, 28 węzłów chłonnych) oraz zmiany łagodne (łącznie 15 obszarów). Badania przeprowadzono w dwóch fazach: początkowej -60min i opóźnionej -90 minut po dożylnej iniekcji radiofarmaceutyku 18 F-FDG. Analiza obejmowała porównanie średniej i maksymalnej standaryzowanej wartości wychwytu SUV: SUVmax, SUVmean oraz jej procentowe zmiany w obu fazach badania. Zmiany o charakterze łagodnym wykazały spadek wychwytu glukozy w czasie, a obszary złośliwe wyraźny wzrost aktywności metabolicznej. AbstractThe aim of this study was to evaluate the usefulness of dual time point (DTP) examinations with

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“…CT with dynamic imaging can not only more accurately differentiate between the benign and malignant nodules but also assess the activities of tuberculomas (Tateishi et al, 2002). More and more diagnostic tools have been reported to measure the activities of pulmonary tuberculoma, such as double phase acquisition of (18) F fluorodeoxyglucose (FDG) positron emission tomography (PET), CT combined with computer-aided diagnosis (CAD), electrocardiograph (ECG)-gated magnetic resonance imaging (MRI), or 99m Tc radioisotope scanning (Kim et al, 2008;Park et al, 2008;Plachcinska et al, 2004;Schaefer et al, 2006). However, there was no statistical difference in the prediction accuracy between the newer imaging techniques or quantitative, computerized measurements and the traditional visual assessments of CT scans by senior radiologists.…”

Section: Operative and Pathological Findingsmentioning

confidence: 99%

Value of video-assisted thoracoscopic surgery in the diagnosis and treatment of pulmonary tuberculoma: 53 cases analysis and review of literature

Hsu

Lee

et al. 2009

J. Zhejiang Univ. Sci. B

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Tuberculoma of the lung is one of manifestations in tuberculosis and usually presents as a solitary pulmonary nodule (SPN). It is difficult to differentiate tuberculoma from SPN by other benign or malignant diseases. At present, the crucial role of video-assisted thoracoscopic surgery (VATS) in diagnosis and treatment of pulmonary diseases has been well acknowledged. Here, we reported 53 patients undergoing VATS resection for tuberculomas in our series. No postoperative mortality was found and only two patients experienced prolonged air-leakage (>7 d) and two had minor wound infections that were recovered after anti-tuberculosis or antibiotic treatment. Anti-tuberculosis chemotherapy from 6 to 12 months was routinely used postoperatively. We conclude that VATS is a satisfactory tool for the diagnosis and treatment of tuberculoma and can also establish a reliable diagnosis for all patients with SPNs.

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Double-phase 18F-FDG PET-CT for determination of pulmonary tuberculoma activity

Cited by 96 publications

References 16 publications

Infection Dynamics and Response to Chemotherapy in a Rabbit Model of Tuberculosis using [ ¹⁸ F]2-Fluoro-Deoxy- d -Glucose Positron Emission Tomography and Computed Tomography

Infection Dynamics and Response to Chemotherapy in a Rabbit Model of Tuberculosis using [ ¹⁸ F]2-Fluoro-Deoxy- d -Glucose Positron Emission Tomography and Computed Tomography

Ocena przydatności badań opóźnionych 18F-FDG PET/CT w różnicowaniu zmian łagodnych i złośliwych

Value of video-assisted thoracoscopic surgery in the diagnosis and treatment of pulmonary tuberculoma: 53 cases analysis and review of literature

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Double-phase 18F-FDG PET-CT for determination of pulmonary tuberculoma activity

Cited by 96 publications

References 16 publications

Infection Dynamics and Response to Chemotherapy in a Rabbit Model of Tuberculosis using [ 18 F]2-Fluoro-Deoxy- d -Glucose Positron Emission Tomography and Computed Tomography

Infection Dynamics and Response to Chemotherapy in a Rabbit Model of Tuberculosis using [ 18 F]2-Fluoro-Deoxy- d -Glucose Positron Emission Tomography and Computed Tomography

Ocena przydatności badań opóźnionych 18F-FDG PET/CT w różnicowaniu zmian łagodnych i złośliwych

Value of video-assisted thoracoscopic surgery in the diagnosis and treatment of pulmonary tuberculoma: 53 cases analysis and review of literature

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Infection Dynamics and Response to Chemotherapy in a Rabbit Model of Tuberculosis using [ ¹⁸ F]2-Fluoro-Deoxy- d -Glucose Positron Emission Tomography and Computed Tomography

Infection Dynamics and Response to Chemotherapy in a Rabbit Model of Tuberculosis using [ ¹⁸ F]2-Fluoro-Deoxy- d -Glucose Positron Emission Tomography and Computed Tomography