Double myelomeningocele: case report

Abderrazzak, Bertal; Hilmani, S.; Elkamar, A; Elazhari, A.

doi:10.3109/02688697.2011.562989

Cited by 4 publications

(4 citation statements)

References 3 publications

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“…Multiple neural tube defects (MNTD) is an extremely uncommon pathology with a prevalence of < 1% out of 474 cases by Ahmad et al [ 2 ] The neural tube starts approximately the first 4 weeks of the embryogenesis period [ 3 ]. The theory behind the development of neural tube defects (NTD) have been entertained by multiple authors, with the classic “zipper-like” fashion that occurs in the mid-cervical region and then continues cranially and caudally in a bi-directional pathway [ [2] , [3] , [4] ]. However, this theory fails to explain the development of MNTD, as one would expect that most NTDs would occur at the cranial or caudal neuropores rather than halfway in between [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

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Presentation of a double myelomeningocele in the upper thoracic and thoracolumbar spine: A case report

Elarjani

Khairy

Al-Karawi

2020

International Journal of Surgery Case Reports

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Section: Discussionmentioning

confidence: 99%

“…Neural tube defects are common in developing countries with an incidence of 0.4–1.9 per 1000 live births [ 1 , 2 ]. Multiple neural tube defects are extremely uncommon, with few cases reported in the literature.…”

Section: Introductionmentioning

confidence: 99%

Presentation of a double myelomeningocele in the upper thoracic and thoracolumbar spine: A case report

Elarjani

Khairy

Al-Karawi

2020

International Journal of Surgery Case Reports

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“…Potter (1962) described two cases and Bertan (1968) described one case of dorsal and lumbar meningomyelocele. [2] Fahrenkurg and Hojgaard (1963) described a case of multiple paravertebral lumbar meningocele. [3] Tekkok reported a case with three distinct NTDs (a parietooccipital encephalocele, a small cervical MMC, and a thoracolumbar MMC).…”

Section: Discussionmentioning

confidence: 99%

Multiple neural tube defects in a child: A rare developmental anomaly

Singh

Singh²,

Aga³

et al. 2012

Surg Neurol Int

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Background:The presence of multiple neural tube defects (NTDs) is a rare entity. Published literature shows not more than 10 case reports. Such cases contradict the well-established “zipper model” of neural tube closure and support “multi-site closure model.”Case Description:We are reporting a unique case of multiple NTDs in a 5-month-o ld female child. Occipital encephalocele, dorsal meningomyelocele, Split cord malformation (SCM), and tethered cord were present in this case.Conclusion:This case report further substantiate the “multisite closure model,” however, more research work on human neuro-embryology is needed to overcome the controversies of neural tube closure.

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“…One of the key arguments for the existence of multiple closure sites as cited in NTD case reports, is that NTDs are found at specific locations in the neural tube (Tekkok, 2005;Etus et al, 2006;Srinivas et al, 2008;Ahmad and Mahapatra, 2009;Vashu and Liew, 2010;Bertal et al, 2011;Singh and Singh, 2012;Mahalik et al, 2013;Garg et al, 2014). With respect to multi-site closure, O'Rahilly and Muller indicated accessory loci of fusion in embryos of the mouse (2002).…”

Section: Literature Search: Specific Locations For Ntdsmentioning

confidence: 99%

Single‐site neural tube closure in human embryos revisited

et al. 2017

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Since the multi-site closure theory was first proposed in 1991 as explanation for the preferential localizations of neural tube defects, the closure of the neural tube has been debated. Although the multi-site closure theory is much cited in clinical literature, single-site closure is most apparent in literature concerning embryology. Inspired by Victor Hamburgers (1900-2001) statement that "our real teacher has been and still is the embryo, who is, incidentally, the only teacher who is always right", we decided to critically review both theories of neural tube closure. To verify the theories of closure, we studied serial histological sections of 10 mouse embryos between 8.5 and 9.5 days of gestation and 18 human embryos of the Carnegie collection between Carnegie stage 9 (19-21 days) and 13 (28-32 days). Neural tube closure was histologically defined by the neuroepithelial remodeling of the two adjoining neural fold tips in the midline. We did not observe multiple fusion sites in neither mouse nor human embryos. A meta-analysis of case reports on neural tube defects showed that defects can occur at any level of the neural axis. Our data indicate that the human neural tube fuses at a single site and, therefore, we propose to reinstate the single-site closure theory for neural tube closure. We showed that neural tube defects are not restricted to a specific location, thereby refuting the reasoning underlying the multi-site closure theory. Clin. Anat. 30:988-999, 2017. © 2017 Wiley Periodicals, Inc.

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Double myelomeningocele: case report

Cited by 4 publications

References 3 publications

Presentation of a double myelomeningocele in the upper thoracic and thoracolumbar spine: A case report

Presentation of a double myelomeningocele in the upper thoracic and thoracolumbar spine: A case report

Multiple neural tube defects in a child: A rare developmental anomaly

Single‐site neural tube closure in human embryos revisited

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