Double-layer closure techniques after bone surgery of medication-related osteonecrosis of the jaw – A single center cohort study

Ristow, Oliver; Rückschloß, Thomas; Bodem, Jens; Berger, Moritz; Bodem, Eva; Kargus, Steffen; Engel, Michael; Hoffmann, Jürgen; Freudlsperger, Christian

doi:10.1016/j.jcms.2018.03.005

Cited by 53 publications

(40 citation statements)

References 42 publications

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“…A recent case series reported successful BFPF in seven MRONJ patients (Procacci et al, ). Ristow et al () presented a retrospective case series with 29 lesions of different MRONJ stages managed with BFPF. The reported healing rate was 93.1% (27/29).…”

Section: Discussionmentioning

confidence: 99%

Surgical treatment of medication‐related osteonecrosis of the upper jaw: Case series

et al. 2018

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Purpose The management of maxillary medication‐related osteonecrosis of the jaw (MRONJ) is challenging. Therefore, identifying the proper treatment is important. This study aimed to evaluate the surgical treatment of maxillary MRONJ using single‐layer closure with mucoperiosteal flap and double‐layer closure with buccal fat pad flap (BFPF) and mucoperiosteal flap and to find the outcomes after rehabilitation with obturators. Methods A retrospective analysis was conducted and included all surgically treated and followed‐up maxillary MRONJ cases in a single center. Demographics and clinical data, stage of MRONJ, surgical treatment, and treatment outcome were collected. Results Seventy‐nine lesions were included. Removal of necrotic bone was followed by coverage with mucoperiosteal flap in 60 lesions and BFPF in 14 lesions. Seven lesions (five primarily and two following unsuccessful treatment with BFPF) underwent necrectomy and were reconstructed with obturators. Complete mucosal healing was achieved in 76.7% of the lesions covered with mucoperiosteal flap. BFPF led to complete mucosal healing in 85.7% of the lesions. No complications were observed in the defects rehabilitated with obturators. Conclusion Removal of necrotic bone followed by closure with mucoperiosteal flap is reliable for MRONJ treatment. BFPF is effective for closure of MRONJ‐related oroantral communications (OACs).

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Section: Discussionmentioning

confidence: 99%

Surgical treatment of medication‐related osteonecrosis of the upper jaw: Case series

et al. 2018

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“…However, there is an increasing body of evidence suggesting that surgical removal of necrotic bone might be curative in patients with all MRONJ stages (Aljohani et al, 2019;Otto et al, 2018;Ristow et al, 2018), where cure is defined as long-term resolution of symptoms and complete mucosal closure (absence of residual bone exposure). Other studies have documented high success rate of surgical treatment compared to non-surgical treatment (Aljohani et al, 2019;Hauer et al, 2019;Yamada et al, 2018).…”

Section: Controver S Ie S On Manag Ement/ Tre Atmentmentioning

confidence: 99%

Workshop of European task force on medication‐related osteonecrosis of the jaw—Current challenges

et al. 2019

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“…Significant advances have been made in the treatment of MRONJ since this condition was first reported in 2003. However, treatment remains challenging, and the prevention of MRONJ is considered the ultimate goal (Ristow et al., 2018, 2019; Ristow, Otto, Troeltzsch, Hohlweg‐Majert, & Pautke, 2015). Although the advantages of (a) antibiotic therapy, (b) atraumatic surgery, (c) alveoplasty, and (d) primary wound closure as preventive measures for tooth extractions under or after antiresorptive therapy have been well documented, no consensus exists with regard to their compilation and interpretation.…”

Section: Discussionmentioning

confidence: 99%

Wound closure and alveoplasty after preventive tooth extractions in patients with antiresorptive intake—A randomized pilot trial

et al. 2020

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Double-layer closure techniques after bone surgery of medication-related osteonecrosis of the jaw – A single center cohort study

Cited by 53 publications

References 42 publications

Surgical treatment of medication‐related osteonecrosis of the upper jaw: Case series

Surgical treatment of medication‐related osteonecrosis of the upper jaw: Case series

Workshop of European task force on medication‐related osteonecrosis of the jaw—Current challenges

Wound closure and alveoplasty after preventive tooth extractions in patients with antiresorptive intake—A randomized pilot trial

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