Double-layer adhesives for preventing anastomotic leakage and reducing post-surgical adhesion

Kang, Sung Il; Shin, Hyun Ho; Hyun, Da Han; Yoon, Ghilsuk; Park, Jun Seok; Ryu, Ji Hyun

doi:10.1016/j.mtbio.2023.100806

Cited by 4 publications

(5 citation statements)

References 52 publications

(67 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Notably, Chi-catechol patches are effective in preventing anastomotic leakage after colorectal surgery by robustly sealing the anastomosis sites in animal models [18]. In addition, gallol-functionalized polymers inspired by plants also show similarly strong tissue-adhesive properties to catechol-functionalized polymers [45][46][47][48][49][50]. Gallol-containing chitosan (Chi-gallol, 10 wt%) hydrogels exhibit strong adhesiveness to porcine skins in the presence of metal ions (Fe 3+ ) or strong oxidants (NaIO 4 ) through electrostatic interactions, hydrogen bonds, cation-π interactions, and subsequent oxidations of remnant pyrogallol functional groups [45].…”

Section: Introductionmentioning

confidence: 99%

“…Chi-gallol films also show tissue adhesiveness with self-wrapping properties, resulting in hemostasis in bleeding mouse liver models [49]. In addition, double-layered patches composed of Chi-gallol and hyaluronic acid successfully prevent anastomotic leakage by sealing anastomosis sites via Chi-gallol-mediated adhesions in animal models [50]. Thus, phenolic-compound-conjugated polymers have remarkable potential as suture support materials.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Bio-Inspired Self-Healing, Shear-Thinning, and Adhesive Gallic Acid-Conjugated Chitosan/Carbon Black Composite Hydrogels as Suture Support Materials

Shin,

Ryu

2023

Biomimetics

Self Cite

View full text Add to dashboard Cite

The occurrence of leakage from anastomotic sites is a significant issue given its potential undesirable complications. The management of anastomotic leakage after gastrointestinal surgery is particularly crucial because it is directly associated with mortality and morbidity in patients. If adhesive materials could be used to support suturing in surgical procedures, many complications caused by leakage from the anastomosis sites could be prevented. In this study, we have developed self-healing, shear-thinning, tissue-adhesive, carbon-black-containing, gallic acid-conjugated chitosan (CB/Chi-gallol) hydrogels as sealing materials to be used with suturing. The addition of CB into Chi-gallol solution resulted in the formation of a crosslinked hydrogel with instantaneous solidification. In addition, these CB/Chi-gallol hydrogels showed enhancement of the elastic modulus (G′) values with increased CB concentration. Furthermore, these hydrogels exhibited excellent self-healing, shear-thinning, and tissue-adhesive properties. Notably, the hydrogels successfully sealed the incision site with suturing, resulting in a significant increase in the bursting pressure. The proposed self-healing and adhesive hydrogels are potentially useful in versatile biomedical applications, particularly as suture support materials for surgical procedures.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Bio-Inspired Self-Healing, Shear-Thinning, and Adhesive Gallic Acid-Conjugated Chitosan/Carbon Black Composite Hydrogels as Suture Support Materials

Shin,

Ryu

2023

Biomimetics

Self Cite

View full text Add to dashboard Cite

show abstract

“…CHI-GA was synthesized using an EDC coupling agent, as previously reported. 50 , 51 Briefly, chitosan (500 mg) was dissolved in distilled deionized water (DDW, 44.5 mL) containing 5 mL of 1 N HCl. The pH was adjusted to 5 by adding 1 N NaOH.…”

Section: Methodsmentioning

confidence: 99%

“…Tissue adhesiveness of the CHI-GA/CK/PCL NFs was examined using a universal testing machine (UTM, Instron 5583, Instron, USA) equipped with a 50 N load cell according to previous research with a slight modification. [50][51][52] The PCL sides of the CHI-GA/CK/PCL NFs (1 × 1 cm 2 ) were attached to the PET film (1 × 5 cm 2 ) using commercially available adhesives (Loctite ® 401, Rocky Hill, Connecticut, USA) resulting in the exposure of the CHI-GA-coated surfaces. In addition, the porcine intestine (1 × 1 cm 2 ) was attached to a PET film (1 × 5 cm 2 ) using commercially available adhesives.…”

Section: Study On Tissue Adhesive Propertiesmentioning

confidence: 99%

Hydrophilic/Hydrophobic Janus Nanofibers Containing Compound K for Cartilage Regeneration

Shin,

Park,

Kim

et al. 2024

IJN

Self Cite

View full text Add to dashboard Cite

Introduction Cartilage regeneration is a challenging issue due to poor regenerative properties of tissues. Electrospun nanofibers hold enormous potentials for treatments of cartilage defects. However, nanofibrous materials used for the treatment of cartilage defects often require physical and/or chemical modifications to promote the adhesion, proliferation, and differentiation of cells. Thus, it is highly desirable to improve their surface properties with functionality. We aim to design hydrophilic, adhesive, and compound K-loaded nanofibers for treatments of cartilage defects. Methods Hydrophilic and adhesive compound K-containing polycaprolactone nanofibers (CK/PCL NFs) were prepared by coatings of gallic acid-conjugated chitosan (CHI-GA). Therapeutic effects of CHI-GA/CK/PCL NFs were assessed by the expression level of genes involved in the cartilage matrix degradation, inflammatory response, and lipid accumulations in the chondrocytes. In addition, Cartilage damage was evaluated by safranin O staining and immunohistochemistry of interleukin-1β (IL-1β) using OA animal models. To explore the pathway associated with therapeutic effects of CHI-GA/CK/PCL NFs, cell adhesion, phalloidin staining, and the expression level of integrins and peroxisome proliferator-activated receptor (PPARs) were evaluated. Results CHI-GA-coated side of the PCL NFs showed hydrophilic and adhesive properties, whereas the unmodified opposite side remained hydrophobic. The expression levels of genes involved in the degradation of the cartilage matrix, inflammation, and lipogenesis were decreased in CHI-GA/CK/PCL NFs owing to the release of CK. In vivo implantation of CHI-GA/CK/PCL NFs into the cartilage reduced cartilage degradation induced by destabilization of the medial meniscus (DMM) surgery. Furthermore, the accumulation of lipid deposition and expression levels of IL-1β was reduced through the upregulation of PPAR. Conclusion CHI-GA/CK/PCL NFs were effective in the treatments of cartilage defects by inhibiting the expression levels of genes involved in cartilage degradation, inflammation, and lipogenesis as well as reducing lipid accumulation and the expression level of IL-1β via increasing PPAR.

show abstract

“…Natural substances that are frequently used include sodium hyaluronate, chitosan, sodium alginate, and others. ,− In practice, however, natural biological polysaccharides like HA degrade rapidly in the body under the action of enzymes. − This makes it challenging to regulate mechanical properties, in vivo retention durations, and blood coagulation reactions. − …”

Section: Introductionmentioning

confidence: 99%

Hemoadhican-Based Bioabsorbable Hydrogel for Preventing Postoperative Adhesions

Lu,

Wang,

Kong

et al. 2024

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

Postoperative peritoneal adhesions are a prevalent clinical issue following abdominal and pelvic surgery, frequently resulting in heightened personal and societal health burdens. Traditional biomedical barriers offer limited benefits because of practical challenges for doctors and their incompatibility with laparoscopic surgery. Hydrogel materials, represented by hyaluronic acid gels, are receiving increasing attention. However, existing antiadhesive gels still have limited effectiveness or carry the risk of complications in clinical applications. Herein, we developed a novel hydrogel using polysaccharide hemoadhican (HD) as the base material and polyethylene glycol diglycidyl ether (PEGDE) as the cross-linking agent. The HD hydrogels exhibit appropriate mechanical properties, injectability, and excellent cytocompatibility. We demonstrate resistance to protein adsorption and L929 fibroblast cell adhesion to the HD hydrogel. The biodegradability and efficacy against peritoneal adhesion are further evaluated in C57BL/6 mice. Our results suggest a potential strategy for antipostoperative tissue adhesion barrier biomaterials.

show abstract

Double-layer adhesives for preventing anastomotic leakage and reducing post-surgical adhesion

Cited by 4 publications

References 52 publications

Bio-Inspired Self-Healing, Shear-Thinning, and Adhesive Gallic Acid-Conjugated Chitosan/Carbon Black Composite Hydrogels as Suture Support Materials

Bio-Inspired Self-Healing, Shear-Thinning, and Adhesive Gallic Acid-Conjugated Chitosan/Carbon Black Composite Hydrogels as Suture Support Materials

Hydrophilic/Hydrophobic Janus Nanofibers Containing Compound K for Cartilage Regeneration

Hemoadhican-Based Bioabsorbable Hydrogel for Preventing Postoperative Adhesions

Contact Info

Product

Resources

About