Double-labelling technique in the evaluation of nasal mucoadhesion of disodium cromoglycate microspheres

Vidgren, P.; Vidgrén, M.; Vainio, Pauli; Nuutinen, Juhani; Paronen, Petteri

doi:10.1016/0378-5173(91)90036-n

Cited by 29 publications

(9 citation statements)

References 11 publications

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“…Mucoadhesive microspheres were labeled with radionuclides such as 99m Tc, or 123 I and their transit through the gastrointestinal tract was observed by gamma scintigraphy. Microspheres of disodium chromoglycate and polyacrylic acid were labeled with 99m Tc for application to nasal cavity to test deposition pattern and clearance studies by gamma scintigraphy [57]. b. Gastrointestinal transit by radio-opaque markers: In this method, radio-opaque marker, such as barium sulphate, is encapsulated in microspheres and the effect of mucoadhesive polymers on the gastrointestinal transit time is determined.…”

Section: In Vivo Methodsmentioning

confidence: 99%

Mucoadhesive Microspheres: A Promising Tool in Drug Delivery

Patil

Sawant²

2008

CDD

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Mucoadhesive polymers have recently gained interest among pharmaceutical scientists as a means of improving drug delivery by promoting the residence time and contact time of the dosage form with the mucous membranes. Mucoadhesion is the process whereby synthetic and natural polymers adhere to mucosal surfaces in the body. If these materials are then incorporated into pharmaceutical formulations, drug absorption by mucosal cells may be enhanced or the drug will be released at the site for an extended period of time. Microspheres, in general, have the potential to be used for targeted and controlled release drug delivery; however, coupling of mucoadhesive properties to microspheres has additional advantages like, a much more intimate contact with the mucus layer, efficient absorption and enhanced bioavailability of the drugs due to a high surface to volume ratio. The present review describes the potential applications of mucoadhesive microspheres as a novel carrier system to improve drug delivery by various routes of administration like buccal, oral, nasal, ocular, vaginal and rectal, either for systemic or for local effects. The mucoadhesive polymers, methods of preparation of microspheres and their in vitro and in vivo evaluation are also described.

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Section: In Vivo Methodsmentioning

confidence: 99%

Mucoadhesive Microspheres: A Promising Tool in Drug Delivery

Patil

Sawant²

2008

CDD

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“…In a gamma scintigraphy study (Vidgren et al 1991), the clearance of disodium cromoglicate particles and disodium-cromoglicate-loaded PAA microparticles in man was investigated. After 30 min, 27% of the plain drug particles and 50% of the PAA microparticles were retained.…”

Section: The Nasal Routementioning

confidence: 99%

Pharmaceutical applications of mucoadhesion for the non-oral routes

Edsman

Hägerström

2005

Journal of Pharmacy and Pharmacology

154

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The adhesion of pharmaceutical formulations to the mucosal tissue offers the possibility of creating an intimate and prolonged contact at the site of administration. This prolonged residence time can result in enhanced absorption and, in combination with a controlled release of the drug, also improved patient compliance by reducing the frequency of administration. During the almost 30 years over which mucoadhesion has been studied, a considerable amount of knowledge has been gained, and much has been learned about the different mechanisms occurring at the formulationmucus interface and the properties that affect these mechanisms. The in-vivo performance of a dosage form not only depends on the mechanisms occurring at the interface, but also on the properties of the total mucoadhesive complex: the dosage form, the mucosa and the interface between them. A wide variety of methods are used for studying mucoadhesion; some rather similar to the in-vivo situation and some mimicking the interface alone. In this review, the mucus surface, the methods used for the study of mucoadhesion, the different mechanisms involved in mucoadhesion and theories underpinning them have been described. The complexity of mucoadhesion when trying to systemize the subject will also be discussed. The last part of the review describes the buccal, nasal, ocular, vaginal and rectal routes and provides examples of what can be achieved in-vivo when using mucoadhesive formulations.

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“…So far, there had been few reports that evaluated the ex vivo mucoadhesion performance (7,8,22,23) of hypoglycemic agents. Sandri et al (24) had highlighted the use of polyacrylic acid in the bilayered formulation for the metformin hydrochloride formulation.…”

Section: Introductionmentioning

confidence: 99%

“…Recently, many investigators have used a combination of polymers using carbopol with other polymers for the development of a mucoadhesive controlled release delivery system of various drugs (4)(5)(6)(7)(8)(9)(10)(11). Earlier, Patel and Charva (12) and Patel et al (13) observed the effect of combined polymers involving carbopol 934P in an attempt to formulate a mucoadhesive drug delivery system for its application to various mucosal sites, but there have been few reports on the use of a single polymer (carbopol 934P) in developing mucoadhesive multiparticulates.…”

Section: Introductionmentioning

confidence: 99%

Study of the Mucoadhesive Potential of Carbopol Polymer in the Preparation of Microbeads Containing the Antidiabetic Drug Glipizide

2015

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Abstract. The present investigation was aimed at exploitation of the mucoadhesive potential of carbopol 934P polymer in developing microbeads of glipizide (GLP) for its effectivity in controlling blood sugar in diabetic patients. Various batches of GLP beads were prepared by an emulsion-solvent evaporation technique using the release-retarding polymer carbopol and subjected to a systematic evaluation such as physical characterization, ex vivo mucoadhesion, hydration and erosion test, and in vitro drug release; and instrumental and in vivo studies were performed with the best formulation. The highest yield and loading efficiency were observed as 94 and ∼90%, respectively. The mean particle size of the microbeads ranged from 832 to 742 μm. The oval shape of the microbeads with slight roughness was apparent in the SEM micrograph. The release period was extended till 18 h. In vitro release of the drug from the beads followed the diffusion and erosion mechanism. In the oral glucose tolerance test (OGTT), there is a significant (p<0.01) reduction in fasting blood glucose levels in Wistar rat and guinea pig in comparison with that using the marketed product. Results indicated that process parameters-drug-polymer ratio, concentration of the surfactant, and stirring speed-controlled the various characteristics of the microparticles. The mucoadhesivity test ensured strong adherence of the beads to the mucosal membrane in pH 1.2 for a prolonged period. Owing to the mucoadhesivity of carbopol 934P, prolonged release of GLP and reduction of fasting sugar in the animal model were observed to a satisfactory level, and thus, management of diabetes in a better manner is expected with this new formulation.

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Double-labelling technique in the evaluation of nasal mucoadhesion of disodium cromoglycate microspheres

Cited by 29 publications

References 11 publications

Mucoadhesive Microspheres: A Promising Tool in Drug Delivery

Mucoadhesive Microspheres: A Promising Tool in Drug Delivery

Pharmaceutical applications of mucoadhesion for the non-oral routes

Study of the Mucoadhesive Potential of Carbopol Polymer in the Preparation of Microbeads Containing the Antidiabetic Drug Glipizide

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