Double labeling: Computation program for a desk-top calculator

Viotti, Angelo; Nucca, Roberto

doi:10.1016/0003-2697(75)90545-x

Cited by 4 publications

(1 citation statement)

References 2 publications

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“…Samples were measured by a double tracer method using 14C-and 65Zn-radioactivity (Sano et a1 1991). In this case, the ''C-radioactivity mixed with 65Zn was converted to an absolute count of 14C according to the calibration curve for quenching based on the spill-over method (Viotti & Nucca 1975), which is generally employed for the measurement of the radioactivity of the 14C-and 3H-double tracers.…”

Section: Measurement Of Radioactivitymentioning

confidence: 99%

Disposition of Polaprezinc (Zinc l-Carnosine Complex) in Rat Gastrointestinal Tract and Effect of Cimetidine on its Adhesion to Gastric Tissues

Furuta

Toyama

Miwa

et al. 1995

Journal of Pharmacy and Pharmacology

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The disposition of polaprezinc in the rat gastrointestinal tract was studied by a double tracer method using [14C]- and [65Zn]polaprezinc. At 0.5 h after oral administration of [14C]-,[65Zn]polaprezinc to rats, the 14C-radioactivity in the gastric contents was comparable with the 65Zn-radioactivity. However, a significant difference was observed in the time course of changes in gastric contents between 14C- and 65Zn-radioactivity over 1 h after administration, indicating that polaprezinc existed in complex form at 0.5 h after administration and was dissociated to L-carnosine and zinc in the gastrointestinal tract as a function of time. The adhesion of zinc to stomach mucosa after oral administration of polaprezinc to rats was significantly increased by treatment with cimetidine. These results suggest that the adhesion of zinc to gastric tissues is increased by inhibiting the dissociation of polaprezinc, and that H2-receptor antagonists, such as cimetidine, may increase anti-ulcer effects of polaprezinc.

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Section: Measurement Of Radioactivitymentioning

confidence: 99%