Double HCG trigger improves recovery of oocytes in women with a paucifollicular response to ovarian stimulation: A pilot study

Galán-Lázaro, Maribel; Mendoza, Nicolás; Mendoza-Tesarik, Raquel

doi:10.1002/ijgo.13735

Cited by 2 publications

(2 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, the probability of early- and late-onset ovarian hyperstimulation syndrome (OHSS) was decreased. Moreover, HCG trigger appears to improve the rate of oocyte recovery, and it is important for loosening the attachment of cumulus oophorus to the follicular wall so as to facilitate their recovery by follicle aspiration ( 23 ). There is uncertainty in the literature regarding both the optimal amount of time, “lag time”, from trigger administration to oocyte aspiration and whether an increased lag time translates into increased mature oocyte yields and better clinical outcomes ( 24 – 26 ).…”

Section: Discussionmentioning

confidence: 99%

Infertility treatment for Chinese women with P450 oxidoreductase deficiency: Prospect on clinical management from IVF to FET

Zhang

2022

Front. Endocrinol.

View full text Add to dashboard Cite

Cytochrome P450 oxidoreductase deficiency (PORD) is a rare recessive disease with multiple clinical manifestations, which is usually diagnosed in neonates and children because of ambiguous genitalia or skeletal malformations. Moreover, the paucity of studies does not allow us to establish whether adult-onset PORD is associated with infertility. Here, we report clinical and laboratory findings in two phenotypically normal women diagnosed with PORD who underwent in vitro fertilization (IVF) and frozen embryo transfer (FET). We modified the gonadotropin stimulation protocol during controlled ovarian hyperstimulation (COH) and suggest the use of the vaginal 17β-estradiol route for endometrium preparation in hormone replacement therapy (HRT) cycles. We presume that PORD may be associated with infertility in several aspects, including disordered steroidogenesis, endometrium impairment, attenuation of drug metabolism, and the high risk of miscarriage. Our observations will help the early diagnosis and make a tailored approach to infertility management in adult-onset PORD.

show abstract

Section: Discussionmentioning

confidence: 99%

Infertility treatment for Chinese women with P450 oxidoreductase deficiency: Prospect on clinical management from IVF to FET

Zhang

2022

Front. Endocrinol.

View full text Add to dashboard Cite

show abstract

“…A double hCG trigger method was utilized in the third cycle to improve oocyte maturation and retrieval. Two doses of hCG were given in the double hCG trigger regimen, each at a 36.5-hour and 12.5-hour gap prior to ovum aspiration [ 6 ]. The goal of this technique was to increase the chance of oocyte retrieval in patients with EFS by offering additional stimulation for oocyte maturation.…”

Section: Case Presentationmentioning

confidence: 99%

The Implications of Double Human Chorionic Gonadotropin (hCG) Trigger on a Pseudo-Empty Follicle Syndrome Patient Seeking Infertility Treatment Through Assisted Reproductive Technology (ART)

Jadhav,

More,

Dutta

et al. 2024

Cureus

View full text Add to dashboard Cite

In the field of assisted reproductive technology (ART), empty follicle syndrome (EFS) is a known condition in which no oocytes are found despite adequate follicular development, which leads to a troublesome situation for patients seeking infertility treatment. In this case study, an EFS patient seeking treatment for infertility at an in vitro fertilization (IVF) clinic was examined to determine the effects of employing a double human chorionic gonadotropin (hCG) trigger. The final oocyte maturation and retrieval are induced by using the double hCG trigger, which includes giving two doses of hCG. In this particular patient, the study looks at the results of follicular development, oocyte retrieval, fertilization rates, embryo quality, and pregnancy rates. The conclusion provides information on how well the double hCG trigger affects treatment outcomes for EFS patients. According to the results of this case study, the two-stage hCG trigger procedure is suggested to enhance the results of oocyte retrieval in the uncategorized EFS patient. In all cycles after the procedural change, the double trigger's application led to effective oocyte maturation and retrieval. The study also showed that the double hCG trigger procedure had no negative consequences on patient safety or ovarian response. There were also no signs of ovarian hyperstimulation syndrome (OHSS) or any other problems. Due to the higher likelihood of oocyte retrieval, the patient also reported better emotional health and less anxiety during subsequent treatment cycles. The positive result of this case study demonstrates the potential advantages of a double hCG trigger procedure in pseudo-EFS patients receiving IVF treatment. When handling EFS cases, this modified strategy may be used as a potential answer by infertility clinics. The effectiveness and safety of the double hCG trigger procedure still need to be confirmed by doing randomized controlled trials on larger populations in order to validate the result.

show abstract

Double HCG trigger improves recovery of oocytes in women with a paucifollicular response to ovarian stimulation: A pilot study

Cited by 2 publications

References 16 publications

Infertility treatment for Chinese women with P450 oxidoreductase deficiency: Prospect on clinical management from IVF to FET

Infertility treatment for Chinese women with P450 oxidoreductase deficiency: Prospect on clinical management from IVF to FET

The Implications of Double Human Chorionic Gonadotropin (hCG) Trigger on a Pseudo-Empty Follicle Syndrome Patient Seeking Infertility Treatment Through Assisted Reproductive Technology (ART)

Contact Info

Product

Resources

About