Double Functionalized Nanoporous Magnetic Gadolinium–Silica Composite for Doxorubicin Delivery

Mehrani, Atousa; Ahmadvand, Parvaneh; Barforushi, Maryam Mehdizadeh; Mehrani, Kheyrollah

doi:10.1007/s10904-015-0302-6

Cited by 13 publications

(7 citation statements)

References 35 publications

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“…All statistical analyses were done with the use of Statistical Package for Social Sciences version 25.0 (IBM Released 2019; IBM SPSS Statistics for Windows, Version 25.0; IBM). 16 Patients in the raw cohorts were categorized by the whether a tourniquet was used, and all preoperative patient and procedural characteristics were compared between cohorts with a preliminary univariate analysis to identify potential factors of statistical difference. After 1:1 matching through a propensity score, univariate analyses were once again done on all covariate and noncovariate variables to check for statistical similarities between the two matched cohorts.…”

Section: Methodsmentioning

confidence: 99%

Outcomes of Tourniquet-Less Revision Total Knee Arthroplasty: A Matched Cohort Analysis

Tirumala

Klemt

Oganseyan

et al. 2021

J Am Acad Orthop Surg

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Introduction: A tourniquet is routinely used in total knee arthroplasty (TKA) to limit perioperative blood loss and increase the visibility of the surgeon's field of view. This study aims to evaluate the postoperative clinical outcomes and complications associated with tourniquet use in revision TKA. Methods: We conducted a retrospective review of 1,904 consecutive patients who underwent revision TKA. Propensity score–based matching was done to adjust for baseline differences in patient demographics and procedure details. Results: Propensity score matching resulted in a cohort of 548 revision total joint arthroplasty patients, 274 (50.0%) of whom were tourniquet patients matched to 274 (50.0%) tourniquet-less patients. Multivariate regression analyses demonstrated that, compared with the tourniquet-less cohort, the tourniquet cohort had significantly less intraoperative (413.7 to 353.2 mL, P < 0.01) and total perioperative (1,548.7 to 1,417.8 mL, P < 0.01) blood loss. However, no significant differences were present in total perioperative (8.4%, 6.6%, P = 0.43) transfusion rates. The tourniquet cohort had increased length of stay (3.2 to 3.7 days, P < 0.001) and 30-day readmissions (P = 0.04). Discussion: This study demonstrated that although omitting the tourniquet in revision TKA leads to markedly increased perioperative blood loss, notable differences in perioperative transfusion rates were not observed. Furthermore, revision TKA without tourniquet use was associated with reduced postoperative length of stay, 30-day readmissions, and increased range of flexion.

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Section: Methodsmentioning

confidence: 99%

Outcomes of Tourniquet-Less Revision Total Knee Arthroplasty: A Matched Cohort Analysis

Tirumala

Klemt

Oganseyan

et al. 2021

J Am Acad Orthop Surg

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“…34 Equally, Li et al reported that an elevated ESR was associated with an increased risk for postoperative complications, in a study with 167 TKA patients investigating risk factors for poor postoperative patients outcomes. 35,36 We performed subgroup analysis for patients with elevated serum markers prior to second-stage TKA reimplantation The findings of this study need to be interpreted in light of several limitations. First, this study has limitations inherent to all retrospective cohort designs such as differential and nondifferential misclassification bias and selection bias.…”

Section: Discussionmentioning

confidence: 99%

Elevated ESR and CRP Prior to Second-Stage Reimplantation Knee Revision Surgery for Periprosthetic Joint Infection Are Associated with Increased Reinfection Rates

et al. 2021

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Purpose Although two-stage revision surgery is considered as the most effective treatment for managing chronic periprosthetic joint infection (PJI), there is no current consensus on the predictors of optimal timing to second-stage reimplantation. This study aimed to compare clinical outcomes between patients with elevated erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) prior to second-stage reimplantation and those with normalized ESR and CRP prior to second-stage reimplantation. Methods We retrospectively reviewed 198 patients treated with two-stage revision total knee arthroplasty for chronic PJI. Cohorts included patients with: (1) normal level of serum ESR and CRP (n = 96) and (2) elevated level of serum ESR and CRP prior to second-stage reimplantation (n = 102). Outcomes including reinfection rates and readmission rates were compared between both cohorts. Result At a mean follow-up of 4.4 years (2.8–6.5 years), the elevated ESR and CRP cohort demonstrated significantly higher reinfection rates compared with patients with normalized ESR and CRP prior to second-stage reimplantation (33.3% vs. 14.5%, p < 0.01). Patients with both elevated ESR and CRP demonstrated significantly higher reinfection rates, when compared with patients with elevated ESR and normalized CRP (33.3% vs. 27.6%, p = 0.02) as well as normalized ESR and elevated CRP (33.3% vs. 26.3%, p < 0.01). Conclusion This study demonstrates that elevated serum ESR and/or CRP levels prior to reimplantation in two-stage knee revision surgery for chronic PJI are associated with increased reinfection rate after surgery. Elevation of both ESR and CRP were associated with a higher risk of reinfection compared with elevation of either ESR or CRP, suggesting the potential benefits of normalizing ESR and CRP prior to reimplantation in treatment of chronic PJI.

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“…Similarly, a subgroup analysis was done using a Pearson chi-square test to investigate whether patients who underwent revision THA, followed by LSF within 1 year have different dislocation rates and rerevision rates than patients who underwent revision THA, followed by LSF within 2 years. 17 Statistical significance was set to two-tailed values of P < 0.05. All statistical analyses were done in SPSS (SPSS Version 18.0; IBM).…”

Section: Methodsmentioning

confidence: 99%

Lumbar Spine Fusion Before Revision Total Hip Arthroplasty Is Associated With Increased Dislocation Rates

Klemt

Padmanabha²,

Tirumala³

et al. 2020

J Am Acad Orthop Surg

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Background: The aim of this study was to determine whether timing of lumbar spinal fusion (LSF) before revision total hip arthroplasty (THA) would impact dislocation and rerevision rates. Methods: This retrospective analysis includes a total of 505 patients who underwent revision THA with concomitant diagnosis of degenerative lumbar spinal stenosis with spondylolisthesis. Patients were stratified into the following two cohorts: (1) 328 patients who underwent revision THA with previous LSF and (2) 177 patients who underwent revision THA, followed by LSF. Postoperative complications including dislocation and rerevision rates were evaluated. Results: Patients who underwent revision THA with previous LSF demonstrated significantly higher dislocation rates and rerevision rates compared with patients who underwent revision THA, followed by LSF, at the 1-year follow-up (6.7% versus 5.1%, P < 0.01; 8.5% versus 7.0%, P = 0.02). Patients who underwent revision THA, followed by LSF within 1 year demonstrated significantly higher dislocation and rerevision rates (5.6% versus 4.1%; 7.6% versus 6.4%). Discussion: This study demonstrates that patients who underwent revision THA with previous LSF demonstrated notably higher dislocation rates and rerevision rates compared with patients who underwent revision THA, followed by LSF, with the greater the intervals between revision THA and LSF, the lower the postoperative dislocation rates and rerevision rates.

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Double Functionalized Nanoporous Magnetic Gadolinium–Silica Composite for Doxorubicin Delivery

Cited by 13 publications

References 35 publications

Outcomes of Tourniquet-Less Revision Total Knee Arthroplasty: A Matched Cohort Analysis

Outcomes of Tourniquet-Less Revision Total Knee Arthroplasty: A Matched Cohort Analysis

Elevated ESR and CRP Prior to Second-Stage Reimplantation Knee Revision Surgery for Periprosthetic Joint Infection Are Associated with Increased Reinfection Rates

Lumbar Spine Fusion Before Revision Total Hip Arthroplasty Is Associated With Increased Dislocation Rates

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