Double functionalisation of carbon nanotubes for multimodal drug delivery

Abstract

Multi-walled carbon nanotubes have been covalently functionalized via 1,3-dipolar cycloaddition of azomethine ylides with orthogonally protected amino functions that can be selectively deprotected and subsequently modified with drugs and fluorescent probes.

Relation between biophysical properties of nanostructures and their toxicity on zebrafish

“…Thus, much research has been carried out to functionalize their surface with attached groups to improve their dispersion and increase their biocompatibility (Fu and Sun 2003). It is noteworthy that, due to their nanosize, CNTs can be great drug delivery systems since they can travel inside the body, easily pass through cellular barriers and transport active compounds either on their surface or inside their structure (Faraji and Wipf 2009;Pastorin et al 2006;Prato et al 2008;Sharma et al 2016). CNT applications are continuously increasing and currently cover electronics, cosmetics, cleaning materials, coatings, food packaging, building materials (de Paula et al 2014) and medicines (Nyilasi et al 2008).…”

Folate and iron difunctionalized multiwall carbon nanotubes as dual-targeted drug nanocarrier to cancer cells

“…For instance, Kam et al have demonstrated the intracellular transportation of DNA [9], siR-NA [10], and proteins [11] using functionalized single-walled carbon nanotubes (f-SWCNTs) as non-targeted drug carriers. Pantarotto et al explored the delivery of bioactive peptides of K(FITC)QRMHLRQYELLC into 3T3 cells [12], methotrexate into Jurkat cells [13] and plasmid DNA into HeLa cells [14], using f-CNTs as non-targeted drug carriers. Additionally, f-CNTs have been applied as the non-targeted drug carriers to transport platinum(IV) [15], oligodeoxynucleotides [16] and boron [17] into cancer cells.…”

Les nanotubes de carbone : un nouvel outil contre le cancer

“…‡ White and brown fat progenitors to transform the ant into cicada? 10. Billon N, Monteiro MC, Dani C. [2].…”