Local sterilization and tissue repair which generally termed as LSTR, brings a radicular change in the field of conservative
dentistry. Efficacy against antibacterial environment and non-surgical healing of periapical lesions much better than
calcium hydroxide. LSTR 3Mix-MP, Using an antibacterial drug combination, therapy is a novel caries, pulpal treatment
of primary tooth and root canal treatment. LSTR 3Mix-MP aims to eliminate causative bacteria from lesions and after
sterilization, the host’s natural tissue recovery process usually the lesions are repaired or resolved. LSTR 3Mix MP where
TAP (triple antibiotics paste) such as: Metronidazole, Ciprofloxacin, Minocycline and Vehicle MP Macrogol/polyethylene
glycol and propylene glycol used to prepare. TAP has great antibacterial efficacy particularly against enterococci which
remains after successful root canal treatment, effective eradication of the causative microorganisms during root canal
treatment procedures. Residual infection in Root canal therapy has always been an area of interdermind or vague for
a treating dental surgeon. Lesion sterilization and tissue repair (LSTR) therapy is a non-surgical or non-conventional
endodontic treatment procedure that involves non-instrumentation or minimal instrumentation followed by placement of
a triple antibiotic paste in a medication along with Macrogol and Propylene glycol.