Double emulsions (W/O/W emulsions): Encapsulation of plant bioactives

Mudrić, Jelena; Šavikin, Katarina; Ibrić, Svetlana; Đuriš, Jelena

doi:10.5937/leksir1939076m

Cited by 12 publications

(4 citation statements)

References 44 publications

(56 reference statements)

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“…Based on the size of the encapsulated particles, nanoencapsulation (10–1000 nm) and microencapsulation (3–800 µm) can be distinguished [ 25 ]. Regarding microencapsulation, there is a wide range of different microencapsulation techniques applied for bioactive compounds such as freeze-drying [ 26 , 27 , 28 , 29 , 30 ], spray-drying [ 26 , 27 , 28 , 29 , 30 , 31 , 32 ], ionic gelation [ 31 , 33 , 34 ], double emulsion solvent evaporation [ 35 ], molecular inclusion in cyclodextrin [ 36 , 37 ], ionic crosslinking method [ 38 , 39 , 40 ], electrospinning [ 41 , 42 , 43 ], and spray-chilling [ 44 ], all of them having some advantages and disadvantages. Among them, SD is one of the most widely used microencapsulation techniques in the manufacturing of food ingredients at a large scale due to a wide range of coating material options, rapid water evaporation, and the possibility to control the temperature to avoid any degradation of the product.…”

Section: Introductionmentioning

confidence: 99%

Impact of Freeze- and Spray-Drying Microencapsulation Techniques on β-Glucan Powder Biological Activity: A Comparative Study

Valková

Ďúranová

Falcimaigne-Cordin

et al. 2022

Foods

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The study compares the impact of freeze- and spray-drying (FD, SD) microencapsulation methods on the content of β-glucan, total polyphenols (TP), total flavonoids (TF), phenolic acids (PA), and antioxidant activity (AA) in commercially β-glucan powder (Pleurotus ostreatus) using maltodextrin as a carrier. Morphology (scanning electron microscopy- SEM), yield, moisture content (MC), and water activity (aw) were also evaluated in the samples. Our examinations revealed significant structural differences between powders microencapsulated by the drying methods. As compared to non-encapsulated powder, the SD powder with yield of 44.38 ± 0.55% exhibited more reduced (p < 0.05) values for aw (0.456 ± 0.001) and MC (8.90 ± 0.44%) than the FD one (yield: 27.97 ± 0.33%; aw: 0.506 ± 0.002; MC: 11.30 ± 0.28%). In addition, the highest values for β-glucan content (72.39 ± 0.38%), TPC (3.40 ± 0.17 mg GAE/g), and TFC (3.07 ± 0.29 mg QE/g) have been detected in the SD powder. Our results allow for the conclusion that the SD microencapsulation method using maltodextrin seems to be more powerful in terms of the β-glucan powder yield and its contents of β-glucan, TP, and TF as compared to the FD technique.

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Section: Introductionmentioning

confidence: 99%

Impact of Freeze- and Spray-Drying Microencapsulation Techniques on β-Glucan Powder Biological Activity: A Comparative Study

Valková

Ďúranová

Falcimaigne-Cordin

et al. 2022

Foods

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“…Prolonged emulsification at high stirring rates can lead to the incorporation of air into the system. During the second stage, stirring should be slow, because otherwise a simple emulsion will be obtained instead of multiple ones [ 165 ].…”

Section: Challenges In the Preparation Of Polysaccharide Microparticlesmentioning

confidence: 99%

Contemporary Aspects of Designing Marine Polysaccharide Microparticles as Drug Carriers for Biomedical Application

Lukova

Katsarov

2023

Pharmaceutics

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The main goal of modern pharmaceutical technology is to create new drug formulations that are safer and more effective. These formulations should allow targeted drug delivery, improved drug stability and bioavailability, fewer side effects, and reduced drug toxicity. One successful approach for achieving these objectives is using polymer microcarriers for drug delivery. They are effective for treating various diseases through different administration routes. When creating pharmaceutical systems, choosing the right drug carrier is crucial. Biomaterials have become increasingly popular over the past few decades due to their lack of toxicity, renewable sources, and affordability. Marine polysaccharides, in particular, have been widely used as substitutes for synthetic polymers in drug carrier applications. Their inherent properties, such as biodegradability and biocompatibility, make marine polysaccharide-based microcarriers a prospective platform for developing drug delivery systems. This review paper explores the principles of microparticle design using marine polysaccharides as drug carriers. By reviewing the current literature, the paper highlights the challenges of formulating polymer microparticles, and proposes various technological solutions. It also outlines future perspectives for developing marine polysaccharides as drug microcarriers.

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“…Herbert [14] emerged as a pioneer in 1965, utilizing multiple emulsions for the controlled release of drugs in pharmaceuticals [15,16]. Double emulsions can be used for the encapsulation of drugs like vitamins [17], vaccines [18], or even certain bioactive compounds extracted from plants [19]. The conception and development of hydrophilic drug distribution systems is an ongoing process in pharmaceutical research.…”

Section: Introductionmentioning

confidence: 99%

Formulation and Characterization of Double Emulsions W/O/W Stabilized by Two Natural Polymers with Two Manufacturing Processes (Comparative Study)

Boudoukhani,

Yahoum,

Ezzroug

et al. 2024

ChemEngineering

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Four distinct types of multiple emulsions were synthesized using xanthan gum and pectin through two distinct manufacturing processes. The assessment encompassed the examination of morphology, stability, and rheological properties for the resulting water-in-oil-in-water (W/O/W) double emulsions. Formulations were meticulously crafted with emulsifiers that were compatible with varying compositions. Remarkably stable multiple emulsions were achieved with a 0.5 wt% xanthan concentration, demonstrating resilience for nearly two months across diverse storage temperatures. In contrast, multiple emulsions formulated with a higher pectin concentration (2.75 wt%) exhibited instability within a mere three days. All multiple emulsions displayed shear-thinning behavior, characterized by a decline in apparent viscosity with escalating shear rates. Comparatively, multiple emulsions incorporating xanthan gum showcased elevated viscosity at low shear rates in contrast to those formulated with pectin. These results underscore the pivotal role of the stepwise process over the direct approach and emphasize the direct correlation between biopolymer concentration and emulsion stability. This present investigation demonstrated the potential use of pectin and xanthan gum as stabilizers of multiple emulsions with potential application in the pharmaceutical industry for the formulation of topical dosage forms.

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Double emulsions (W/O/W emulsions): Encapsulation of plant bioactives

Cited by 12 publications

References 44 publications

Impact of Freeze- and Spray-Drying Microencapsulation Techniques on β-Glucan Powder Biological Activity: A Comparative Study

Impact of Freeze- and Spray-Drying Microencapsulation Techniques on β-Glucan Powder Biological Activity: A Comparative Study

Contemporary Aspects of Designing Marine Polysaccharide Microparticles as Drug Carriers for Biomedical Application

Formulation and Characterization of Double Emulsions W/O/W Stabilized by Two Natural Polymers with Two Manufacturing Processes (Comparative Study)

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