Double emulsions prepared by two–step emulsification: History, state-of-the-art and perspective

Ding, Shukai; Serra, Christophe A.; Vandamme, Thierry F.; Yu, Wei; Anton, Nicolas

doi:10.1016/j.jconrel.2018.12.037

Cited by 185 publications

(129 citation statements)

References 98 publications

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“…A multiple emulsion is an example of hierarchical soft fluid, consisting of smaller drops (often named as cores) dispersed within a larger one and stabilized by means of surfactants adsorbed onto the interfaces [1][2][3][4]. A typical example in point is a collection of distinct water drops (either monodisperse or polidisperse) encapsulated within an oil one.…”

Section: Introductionmentioning

confidence: 99%

“…Recent microfluidic experiments have been capable of designing highly regular and well-defined multi-core emulsions with an extremely controlled procedure [1,[3][4][5][6][7][8]. The process essentially consists of two emulsification steps, one in which water droplets are dispersed in oil phase and a second one in which they are embedded in the same oil phase [1,3,9].…”

Section: Introductionmentioning

confidence: 99%

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Concentrated phase emulsion with multicore morphology under shear: A numerical study

et al. 2020

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We numerically study the dynamic behavior under a symmetric shear flow of selected examples of concentrated phase emulsions with multi-core morphology confined within a microfluidic channel. A variety of new nonequilibrium steady states is reported. Under low shear rates, the emulsion is found to exhibit a solid-like behavior, in which cores display a periodic planetary-like motion with approximately equal angular velocity. At higher shear rates two steady states emerge, one in which all inner cores align along the flow and become essentially motionless and a further one in which some cores accumulate near the outer interface and produce a dynamical elliptical-shaped ring chain, reminiscent of a treadmilling-like structure, while others occupy the center of the emulsion. A quantitative description in terms of i) motion of the cores, ii) rate of deformation of the emulsion and iii) structure of the fluid flow within the channel is also provided.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Concentrated phase emulsion with multicore morphology under shear: A numerical study

et al. 2020

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“…Here, we aimed to design and characterize OXC loaded PLGA nanoparticles for IA injections in the treatment of OA to provide sustained release of OXC and minimize injection frequency to improve patient compliance. PLGA nanoparticles were fabricated by double‐emulsion method due to hydrophilicity of OXC (S. Ding, Serra, Vandamme, Yu, & Anton, ; Sipahigil et al., ). Herein, first, formulation variables including polymer amount, speed and duration of homogenization were investigated to determine the optimum nanoparticle formulation.…”

Section: Introductionmentioning

confidence: 99%

Development and characterization of oxaceprol‐loaded poly‐lactide‐co‐glycolide nanoparticles for the treatment of osteoarthritis

Alarçin

Demirbağ

Karslı-Çeppioğlu

et al. 2020

Drug Development Research

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Oxaceprol is well-defined therapeutic agent as an atypical inhibitor of inflammation in osteoarthritis. In the present study, we aimed to develop and characterize oxaceprol-loaded poly-lactide-co-glycolide (PLGA) nanoparticles for intra-articular administration in osteoarthritis. PLGA nanoparticles were prepared by doubleemulsion solvent evaporation method. Meanwhile, a straightforward and generally applicable high performance liquid chromatography method was developed, and validated for the first time for the quantification of oxaceprol. To examine the drug carrying capacity of nanoparticles, varying amount of oxaceprol was entrapped into a constant amount of polymer matrix. Moreover, the efficacy of drug amount on nanoparticle characteristics such as particle size, zeta potential, morphology, drug entrapment, and in vitro drug release was investigated. Nanoparticle sizes were between 229 and 509 nm for different amount of oxaceprol with spherical smooth morphology. Encapsulation efficiency ranged between 39.73 and 63.83% by decreasing oxaceprol amount. The results of Fourier transform infrared and DSC showed absence of interaction between oxaceprol and PLGA. The in vitro drug release from these nanoparticles showed a sustained release of oxaceprol over 30 days. According to cell culture studies, oxaceprol-loaded nanoparticles had no cytotoxicity with high biocompatibility. This study was the first step of developing an intra-articular system in the treatment of osteoarthritis for the controlled release of oxaceprol. Our findings showed that these nanoparticles can be beneficial for an effective treatment of osteoarthritis avoiding side effects associated with oral administration. K E Y W O R D Sintra-articular injection, nanoparticle, osteoarthritis, oxaceprol, PLGA

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“…However, DEs do not provide solid-like texture unless oil droplets are closely packed [4,5]. Gelling of the internal [3,6,7] or external aqueous phase [8][9][10][11][12][13], together with the structuring of the oil phase [3,14] are among the different strategies attempted for stabilizing DEs [15]. However, the gelation of the external aqueous phase, embedding the emulsion droplets in a continuous hydrogel matrix, is the most promising strategy to also provide a fat analog with solid-like properties [4].…”

Section: Introductionmentioning

confidence: 99%

Influence of gelation on the retention of purple cactus pear extract in microencapsulated double emulsions

et al. 2020

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A purple cactus pear (Opuntia ficus-indica) extract (CP) was encapsulated in double emulsions (DE) gelled with gelatin (DE-CP-G) and with gelatin and transglutaminase (DE-CP-GT), as well as in a DE with a liquid external aqueous phase (DE-CP), in order to study the retention of betanin as colorant agent. Both gelled DEs showed a predominantly elastic behavior, in contrast with DE-CP. The degradation rate constant of betanin was significantly higher in DE-CP-GT (90.2 x 10 −3 days-1) than in DE-CP-G (11.0 x 10 −3 days-1) and DE-CP (14.6 x 10 −3 days-1) during cold-storage (4˚C). A shift towards yellow color was found in all the systems during cold-storage (4˚C) and after thermal treatment (70˚C/30 min), especially in DE-CP-GT, denoting a higher degradation of betanin. Betalamic acid, cyclo-Dopa 5-O-βglucoside, 17-decarboxy-betanin and neobetanin were identified by UHPLC-MS/MS as degradation products of betanin.

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Double emulsions prepared by two–step emulsification: History, state-of-the-art and perspective

Cited by 185 publications

References 98 publications

Concentrated phase emulsion with multicore morphology under shear: A numerical study

Concentrated phase emulsion with multicore morphology under shear: A numerical study

Development and characterization of oxaceprol‐loaded poly‐lactide‐co‐glycolide nanoparticles for the treatment of osteoarthritis

Influence of gelation on the retention of purple cactus pear extract in microencapsulated double emulsions

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