Double-edged roles of ferroptosis in endometriosis and endometriosis-related infertility

Li, Yangshuo; He, Yalun; Cheng, Wen; Zhou, Zhihao; Ni, Zhexin; Yu, Chaoqin

doi:10.1038/s41420-023-01606-8

Cited by 8 publications

(1 citation statement)

References 128 publications

(160 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…the evolutionary factor), would accelerate disease promotion , based on the local metabolic and endocrine activities of ectopic endometrial implants ( Bulun et al , 2019 ). Thirdly, prolonged exposure to excessive ferrous iron and interactions with ferroptosis pathways would exacerbate inflammation, induce fibrosis, and facilitate survival and infiltration of ectopic endometrial cells, thereby fostering disease progression ( Ng et al , 2020 ; Li et al , 2021 , 2022 , 2023 ; Zhang et al , 2022 ; Huang et al , 2023 ; Kobayashi et al , 2023 ; Liu et al , 2023 ; Wyatt et al , 2023 ).…”

Section: Discussionmentioning

confidence: 99%

Is retrograde menstruation a universal, recurrent, physiological phenomenon? A systematic review of the evidence in humans and non-human primates

Viganò,

Caprara,

Giola

et al. 2024

Human Reproduction Open

View full text Add to dashboard Cite

STUDY QUESTION What are the quantitative, qualitative and temporal patterns of retrograde mentruation? SUMMARY ANSWER The extreme quantitative and qualitative heterogeneity of the available studies prevents the definitive conclusion that retrograde menstruation is a universal and consistent phenomenon during the reproductive period. WHAT IS KNOWN ALREADY Retrograde menstruation has been defined as a universal, physiological phenomenon that occurs similarly in about 90% of menstruators during the reproductive period. However, uncertainties still exists in terms of the event frequency, total amount and cellular composition of retrograde menstruation and the differences between individuals with versus those without endometriosis. STUDY DESIGN, SIZE, DURATION Two systematic reviews were performed, one for human studies and one for non-human primate studies. We retrieved studies from the PubMed and Embase databases published between January 1, 1980 and November 1, 2023. Studies published in the English language were included and identified using a combination of MeSH terms. References from relevant publications were systematically screened and further articles were identified using PubMed’s “similar articles” and “cited by” functions. PARTICIPANTS/MATERIALS, SETTING, METHODS Results were reported in accordance with the PRISMA guidelines. Studies that did not report original data or provided a review of the field were excluded. Bias analysis was completed for each included human study by using the Newcastle-Ottawa scoring system. MAIN RESULTS AND THE ROLE OF CHANCE Fifteen studies were finally included in the human systematic review, mostly with limited sample sizes. The macroscopic visualization of blood in PF during menses was reported with a frequency ranging from 9% to 100%. A prevalence of endometrial cells detected in peritoneal fluid ranging from 8% to 75% was reported in the various studies. Controversial findings were reported in relation to patients with endometriosis. Retrograde menstruation has been evaluated cross-sectionally on single occasions, and no information is available on the course of the phenomenon within an entire cycle and between subsequent cycles. Two studies were included in the non-human primate systematic review; one of them showed that retrograde menstruation was observed more frequently in baboons with naturally occurring endometriosis (83%) than in those with a normal pelvis (51%). LIMITATIONS, REASONS FOR CAUTION In humans, peritoneal fluid has often been collected at different cycle phases and not systematically during menstruation. The indication for laparoscopy was not always clear for all participants. A wide variety of methods were used to detect endometrial cells, including cytological staining, cell block analysis, immunocytochemistry and various methods of cell culture. WIDER IMPLICATION OF THE FINDINGS The idea that almost all women experience retrograde menstruation regularly and similarly during their reproductive life is currently unsubstantiated. It is an academic notion accepted with criticism. Development of endometriosis may derive from differences in the frequency or severity of the event. STUDY FUNDING/COMPETING INTERESTS The review was partially funded by Italian Ministry of Health—Current Research IRCCS. PVi serves as co-editor in Chief of Journal of Endometriosis and Uterine Disorders. E.S. serves as Editor in Chief of Human Reproduction Open and discloses research grants from Ferring, Ibsa, Gedeon Richter and Theramex, and honoraria from Ibsa and Gedeon Richter. P.Ve. serves as Associate Editor for Human Reproduction Open; is a member of the Editorial Board of the Journal of Obstetrics and Gynaecology Canada, of the Italian Journal of Obstetrics and Gynaecology, and of the International Editorial Board of Acta Obstetricia et Gynecologica Scandinavica; has received royalties from Wolters Kluwer for chapters on endometriosis management in the clinical decision support resource UpToDate; and maintains both a public and private gynaecological practice. All other authors declare they have no conflict of interest. TRIAL REGISTRATION NUMBER N/A

show abstract

Section: Discussionmentioning

confidence: 99%

Is retrograde menstruation a universal, recurrent, physiological phenomenon? A systematic review of the evidence in humans and non-human primates

Viganò,

Caprara,

Giola

et al. 2024

Human Reproduction Open

View full text Add to dashboard Cite

show abstract

Creatine Promotes Endometriosis by Inducing Ferroptosis Resistance via Suppression of PrP

Chen,

Ma,

Liu

et al. 2024

Advanced Science

View full text Add to dashboard Cite

Endometriosis, a chronic inflammatory disease, significantly impairs the quality of life of women in their reproductive years; however, its pathogenesis remains poorly understood. The accumulation of retrograde menstruation and recurrent bleeding fosters a high‐iron environment in ectopic lesions, triggering ferroptosis in ectopic endometrial stromal cells (EESCs), thereby hindering the establishment of endometriosis. However, abnormal EESCs demonstrate resistance to ferroptosis in high‐iron environments, promoting the progression of this disease. Here, novel findings on the accumulation of creatine, derived from endogenous synthesis, in both peritoneal fluid and EESCs of patients with endometriosis are presented. Creatine supplementation reduces cellular iron concentrations, mitigating oxidative stress and lipid peroxidation, thereby enhancing cell viability and preventing ferroptosis under high‐iron conditions. Utilizing the drug affinity–responsive target stabilization (DARTS) assay, prion protein (PrP) as a potential creatine‐sensing protein is identified. Mechanistically, creatine binds to the active site of PrP, inhibits the conversion of trivalent iron to divalent iron, and decreases iron uptake, promoting the tolerance of EESCs to ferroptosis. This interaction contributes to the development of endometriosis. The novel association between creatine and ferroptosis provides valuable insights into the role of creatine in endometriosis progression and highlights its potential as a therapeutic target for endometriosis.

show abstract

Rapid screening of infertility-associated gynecological conditions via ambient glow discharge mass spectrometry utilizing urine metabolic fingerprints

Qu,

Chen,

Wang

et al. 2024

Talanta

View full text Add to dashboard Cite

Double-edged roles of ferroptosis in endometriosis and endometriosis-related infertility

Cited by 8 publications

References 128 publications

Is retrograde menstruation a universal, recurrent, physiological phenomenon? A systematic review of the evidence in humans and non-human primates

Is retrograde menstruation a universal, recurrent, physiological phenomenon? A systematic review of the evidence in humans and non-human primates

Creatine Promotes Endometriosis by Inducing Ferroptosis Resistance via Suppression of PrP

Rapid screening of infertility-associated gynecological conditions via ambient glow discharge mass spectrometry utilizing urine metabolic fingerprints

Contact Info

Product

Resources

About