Double Dissociation between Motor and Visual Imagery in the Posterior Parietal Cortex

Pelgrims, Barbara; Andres, Michaël; Olivier, Etienne

doi:10.1093/cercor/bhn248

Cited by 62 publications

(56 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Indeed, the finding that only left SMG virtual lesions altered the motor judgment task may seem at odds with some studies showing an equal contribution of both hemispheres in mental rotation of hand postures [Pelgrims et al, 2009]. However, except perhaps for complex movements such as sequential movements involving multiple fingers [Haaland et al, 2004;Verstynen et al, 2005], an involvement of the two hemispheres seems to be specific to intransitive gestures and may explain the higher resistance of those movements to unilateral brain damage [Johnson-Frey et al, 2005].…”

Section: Discussionmentioning

confidence: 95%

“…For instance, in a series of neuropsychological studies, Tomasino and colleagues have shown that patients with left hemispheric lesions experience difficulties in doing mental object rotations when perceived as a result of their own manual activity, whereas they are still able to perform the task when the instructions emphasize the use of visual imagery. Accordingly, we recently demonstrated that visual imagery relies on distinct brain areas in the superior parietal lobule [Pelgrims et al, 2009].…”

Section: Discussionmentioning

confidence: 99%

“…An indication of the timing of the manipulation judgement is provided by a MEG study showing that the activation of the inferior parietal lobule may be observed as soon as 130 ms after the stimuli presentation during a hand laterality judgment [Kawamichi et al, 1998]. Congruently, in a previous study, a similar TMS protocol was used successfully to interfere with a motor imagery task requiring a verbal response [Pelgrims et al, 2009].…”

Section: Transcranial Magnetic Stimulationmentioning

confidence: 99%

See 2 more Smart Citations

Dissociation between manipulation and conceptual knowledge of object use in the supramarginalis gyrus

Pelgrims

Olivier

Andres

2010

Human Brain Mapping

View full text Add to dashboard Cite

Because tool naming activates motor-related areas in the posterior parietal cortex, it has been suggested that conceptual knowledge of tools relies on their unique manipulation patterns. However, this view is questioned by the finding that some patients impaired in retrieving manipulation knowledge of man-made objects are still able to perform conceptual judgments on them. To address this issue, we used repetitive transcranial magnetic stimulation (rTMS) to interfere with the functioning of the anterior part of the right or left supramarginalis gyrus (SMG), a region critically involved in object-directed actions. rTMS was delivered in healthy participants performing four judgment tasks designed to explore different aspects of manipulation and conceptual knowledge of man-made objects. The two manipulation judgment tasks consisted in determining whether (1) two objects displayed on a computer screen are normally used by adopting a comparable hand posture, or (2) a given hand posture is appropriate to use an object. In the two conceptual judgment tasks, subjects had to decide whether (1) two objects displayed on the computer screen are normally used in the same context or (2) they are functionally related. We found that virtual lesions of left SMG interfere only with the performance of the manipulation judgment task in which subjects had to decide whether two different objects are used by adopting the same hand posture, all the other tasks being unaltered. rTMS applied over the right SMG had no effect. These results challenge the assumption that conceptual knowledge of tools is grounded upon motor representations.

show abstract

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Transcranial Magnetic Stimulationmentioning

confidence: 99%

See 1 more Smart Citation

Dissociation between manipulation and conceptual knowledge of object use in the supramarginalis gyrus

Pelgrims

Olivier

Andres

2010

Human Brain Mapping

View full text Add to dashboard Cite

show abstract

“…Such a task has been consistently proved to involve mental simulation of hand movements [Parsons, 1987b;Sekiyama, 1982;Thayer and Johnson, 2006] and to be influenced by the same motor constraints (e.g. biomechanical limitations) as ME [Parsons, 1987a[Parsons, ,b, 2001Pelgrims et al, 2009;Petit et al, 2003]. Moreover, because mental rotation remained implicit in this task, it also allowed us to overcome the possible limitations related to the use of different strategies by participants [Johnson, 2000].…”

Section: Introductionmentioning

confidence: 99%

Contribution of the primary motor cortex to motor imagery: A subthreshold TMS study

Pelgrims¹,

Michaux²,

Olivier³

et al. 2010

Human Brain Mapping

View full text Add to dashboard Cite

Motor imagery (MI) mostly activates the same brain regions as movement execution (ME) including the primary motor cortex (Brodmann area 4, BA4). However, whether BA4 is functionally relevant for MI remains controversial. The finding that MI tasks are impaired by BA4 virtual lesions induced by transcranial magnetic stimulation (TMS) supports this view, though previous studies do not permit to exclude that BA4 is also involved in other processes such as hand recognition. Additionally, previous works largely underestimated the possible negative consequences of TMS-induced muscle twitches on MI task performance. Here we investigated the role of BA4 in MI by interfering with the function of the left or right BA4 in healthy subjects performing a MI task in which they had to make laterality judgements on rotated hand drawings. We used a subthreshold repetitive TMS protocol and monitored electromyographic activity to exclude undesirable effects of hand muscle twitches. We found that BA4 virtual lesions selectively increased reaction times in laterality judgments on hand drawings, leaving unaffected a task of equal difficulty, involving judgments on letters. Interestingly, the effects of virtual lesions of left and right BA4 on MI task performance were the same irrespective of the laterality (left/right) of hand drawings. A second experiment allowed us to rule out the possibility that BA4 lesions affect visual or semantic processing of hand drawings. Altogether, these results indicate that BA4 contribution to MI tasks is specifically related to the mental simulation process and further emphasize the functional coupling between ME and MI.

show abstract

“…SMG is an important area for motor representation and motor imagery. 35 It may be speculated that the absence of negative interaction from M1, Ce, and SMA to SMG in patients indicates impaired mental representation of finger movements. A robust positive interaction between Ce and the vermis was found in patients.…”

mentioning

confidence: 99%

Altered functional connectivity in the motor network after traumatic brain injury

Kasahara

Menon²,

Salmond³

et al. 2010

Neurology

100

View full text Add to dashboard Cite

Background: A large proportion of survivors of traumatic brain injury (TBI) have persistent cognitive impairments, the profile of which does not always correspond to the size and location of injuries. One possible explanation could be that TBI-induced damage extends beyond obvious lesion sites to affect remote brain networks. We explored this hypothesis in the context of a simple and well-characterized network, the motor network. The aim of this cross-sectional study was to establish the residual integrity of the motor network as an important proof of principle of abnormal connectivity in TBI.Methods: fMRI data were obtained from 12 right-handed patients and 9 healthy controls while they performed the finger-thumb opposition task with the right hand. We used both conventional and psychophysiologic interaction (PPI) analyses to examine the integrity of functional connections from brain regions we found to be activated in the paradigm we used.Results: As expected, the analysis showed significant activations of the left primary motor cortex (M1), right cerebellum (Ce), and bilateral supplementary motor area (SMA) in controls. However, only the activation of M1 survived robust statistical thresholding in patients. In controls, the PPI analysis revealed that left M1, SMA, and right Ce positively interacted with the left frontal cortex and negatively interacted with the right supramarginal gyrus. In patients, we observed no negative interaction and reduced interhemispheric interactions from these seed regions.Conclusions: These observations suggest that patients display compromised activation and connectivity patterns during the finger-thumb opposition task, which may imply functional reorganization of motor networks following TBI.

show abstract

Double Dissociation between Motor and Visual Imagery in the Posterior Parietal Cortex

Cited by 62 publications

References 68 publications

Dissociation between manipulation and conceptual knowledge of object use in the supramarginalis gyrus

Dissociation between manipulation and conceptual knowledge of object use in the supramarginalis gyrus

Contribution of the primary motor cortex to motor imagery: A subthreshold TMS study

Altered functional connectivity in the motor network after traumatic brain injury

Contact Info

Product

Resources

About