Double Dissociation between Meaningful and Meaningless Gesture Reproduction in Apraxia

Bartolo, Angela; Cubelli, Roberto; Sala, Sergio Della; Drei, Silvia; Marchetti, C.

doi:10.1016/s0010-9452(08)70617-8

Cited by 85 publications

(69 citation statements)

References 9 publications

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“…This bidirectional influence between action observation and execution suggested to us to include both types of tasks in rehabilitation programs for LA (Smania et al, 2000;. As posited by influential cognitive neuropsychological models of apraxia (Rothi et al, 1991;Cubelli et al, 2000) and demonstrated by clinical studies (Goldenberg and Hagmann, 1997;Cubelli et al, 2000;Bartolo et al, 2001;Rumiati et al, 2001;Tessari et al, 2007), the range of possible dissociations between action execution and action understanding that can occur in apraxia is quite multifarious and cannot be explained by a mere action mirroring mechanism nor by a single lesion locus. Indeed, failures in imitating or in recognizing gestures may occur because of damage to a putative action semantics system or because of damage at any level in the process between perceiving (input lexicon) and performing (output lexicon) an action (Rothi et al, 1991;Cubelli et al, 2000).…”

Section: Seeing and Doing In Apraxiamentioning

confidence: 90%

“…Patients with apraxia may be impaired in executing both gestures that involve the use of objects (transitive), such as hammering a nail, and gestures not involving object use (intransitive), such as the hitchhiking sign (Cubelli et al, 2000). Although the impairment of meaningful (e.g., waving goodbye) and meaningless (e.g., moving a hand) gestures may be doubly dissociated (Goldenberg and Hagmann, 1997;Bartolo et al, 2001), apraxic patients often exhibit deficits in both types of gestures (Toraldo et al, 2001;Leiguarda, 2005), at least when presented in an intermingled list (Tessari et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

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Neural Underpinnings of Gesture Discrimination in Patients with Limb Apraxia

Pazzaglia¹,

et al. 2008

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Limb apraxia (LA), is a neuropsychological syndrome characterized by difficulty in performing gestures and may therefore be an ideal model for investigating whether action execution deficits are causatively linked to deficits in action understanding. We tested 33 left brain-damaged patients and 8 right brain-damaged patients for the presence of the LA. Importantly, we also tested all the patients in an ad hoc developed gesture recognition task wherein an actor performs, either correctly or incorrectly, transitive (using objects) or intransitive (without objects) meaningful conventional limb gestures. Patients were instructed to judge whether the observed gesture was correct or incorrect. Lesion analysis enabled us to evaluate the relationship between specific brain regions and behavioral performance in gesture execution and gesture comprehension. We found that LA was present in 21 left brain-damaged patients and it was linked to frontal and parietal lesions. Moreover, we found that recognition of correct execution of familiar gestures performed by others was more impaired in patients with LA than in nonapraxic patients. Crucially, the gesture comprehension deficit correlated with damage to the opercular and triangularis portions of the inferior frontal gyrus, two regions that are involved in complex aspects of action-related processing. In contrast, no such relationship was observed with lesions centered on the inferior parietal cortex. The present findings suggest that lesions to left frontal regions that are involved in planning and performing actions are causatively associated with deficits in the recognition of the correct execution of meaningful gestures.

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Section: Seeing and Doing In Apraxiamentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Neural Underpinnings of Gesture Discrimination in Patients with Limb Apraxia

Pazzaglia¹,

et al. 2008

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“…When meaningful and meaningless gestures were presented intermingled, patients' ability to imitate either action types did not differ (see De Renzi et al 1980;Cubelli et al 2000;Toraldo et al 2001, for similar findings). However, when patients' ability to imitate was evaluated using separate lists, six patients had a selective imitation deficit for meaningless actions (see Goldenberg & Hagmann 1997;Peigneux et al 2000;Bartolo et al 2001, for similar results), and two had a selective imitation deficit for meaningful actions (see Bartolo et al 2001 for similar results). This study suggests that patients performing the imitation task in the mixed condition selected the non-semantic route because it allows the reproduction of all gestures and avoids high costs of switching between routes.…”

Section: The Dual Route Model and Other Accounts Of Imitationmentioning

confidence: 90%

“…While, in general, the production of transitive gestures seems to be affected more by left hemisphere lesions (Bartolo et al 2001;Tessari et al 2007), the ability to generate intransitive gestures can be equally disrupted by damage to either cerebral hemisphere (Buxbaum et al 2007). But, there are also studies suggesting that defective performance with both transitive and intransitive gestures is more likely to follow left than right hemisphere damage (Hanna-Pladdy et al 2001).…”

Section: Imitation Of Intransitive Gesturesmentioning

confidence: 98%

“…In that of Tessari et al (2007), cases 30 and 31 imitated meaningful, object-related pantomimes (10 and 50%, respectively) significantly better than meaningless gestures, but could nevertheless correctly identify them (90 and 100%, respectively). Bartolo et al (2001) described a patient, M.F., who performed poorly on all tests of production of meaningful gestures, including imitation, but was flawless in meaningless gesture imitation; interestingly, her discrimination and comprehension of meaningful actions were spared. These dissociating patterns indicate that gesture imitation can be impaired despite normal performance in gesture perception and that the ability to imitate gestures might not be necessary for recognizing them.…”

Section: Where Does Imitation Stand Relative To Other Cognitive Functmentioning

confidence: 99%

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Neuropsychological perspectives on the mechanisms of imitation

Rumiati

Carmo

Corradi‐Dell’Acqua

2009

Phil. Trans. R. Soc. B

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Cognitive neuroscientists have contributed to the understanding of imitation according to their expertise. Neuropsychologists first established over a century ago that lesions to the left hemisphere of right-handed individuals lead to a dramatic reduction of their ability to imitate gestures. In contrast, after frontal lobe damage, patients may experience severe difficulties in inhibiting their imitative tendency. These findings suggested that our tendency to imitate is mostly sustained by the left hemisphere and that we normally manage successfully to keep it under control. Neuropsychologists went on investigating other aspects of gesture imitation. These include the existence of putative mechanisms involved in imitating different types of gestures (e.g. meaningful and meaningless or transitive and intransitive), the strategic control over these mechanisms and whether there are differences in imitation depending on the action goal or the body part used. Based on neuropsychological findings, some cognitive models of gesture imitation have been forwarded, the most influential of which will be reviewed here. In particular, reference will be made to the dual route model and to accounts that associate the imitative deficit to putative degraded body representations.

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Neuropsychological basis of impaired gesture imitations in patients with Alzheimer's disease and dementia with Lewy bodies

Nagahama

Okina

Suzuki

2021

Int J Geriat Psychiatry

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Introduction The aim of this study was to examine the neuropsychological factors that may be related to the impaired gesture imitations in patients with dementia. Methods The imitation of unilateral finger and bimanual gestures was evaluated in 162 patients with Alzheimer's disease (AD) and 103 patients with dementia with Lewy bodies (DLB). The relationships of gesture imitation performance to global cognition, semantic fluency, phonemic fluency, figure copying, clock drawing, and trail‐making test part A (TMT‐A) scores were examined. Results Mean scores for unilateral finger imitation were significantly lower in DLB patients than in AD patients, and significantly more DLB patients showed impaired performance in unilateral finger imitation than AD patients. In contrast, the percentage of patients with impaired bimanual gesture imitation was not significantly different between AD and DLB patients. Unilateral finger imitation performance was predicted by pentagon copying in the AD patients, and was predicted by cube copying in the DLB patients. Bimanual gesture imitation performance was predicted by TMT‐A scores and phonemic fluency in the AD patients but was predicted by TMT‐A scores, cube copying, and parkinsonism severity in the DLB patients. Discussion Our study suggested that bimanual gesture imitation is a complex task that is supported by a wide range of neuropsychological processes, such as visuospatial attention, executive function, and visuomotor control, and therefore, it was easily impaired in early dementia. Unilateral finger imitation was more similar to constructional tasks, such as figure drawing, and was impaired more often in DLB patients than in AD patients.

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Double Dissociation between Meaningful and Meaningless Gesture Reproduction in Apraxia

Cited by 85 publications

References 9 publications

Neural Underpinnings of Gesture Discrimination in Patients with Limb Apraxia

Neural Underpinnings of Gesture Discrimination in Patients with Limb Apraxia

Neuropsychological perspectives on the mechanisms of imitation

Neuropsychological basis of impaired gesture imitations in patients with Alzheimer's disease and dementia with Lewy bodies

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