Double contrast-enhanced ultrasound for the preoperative gross classification of gastric cancer: a comparison with multidetector computed tomography

Abstract

Purpose To compare the diagnostic performance of double contrast-enhanced ultrasound (DCEUS) and multi-detector row computed tomography (MDCT) in the gross classification of gastric cancer (GC) preoperatively. Methods 54 patients with histology proved GC were included in this retrospective study. The sensitivity and specificity of DCEUS and MDCT for the gross classification of GC was calculated and compared. The area under the curve (AUC) from a receiver operating characteristic curve analysis was used to evaluate the difference of the diagnostic performance between these two methods. Results There were no significant differences between DCEUS and MDCT in terms of AUC for early gastric cancer (EGC), Borrmann I, II, III and Borrmann (III + IV) (P = 0.248, 0.317, 0.717, 0.464 and 0.594, respectively). The accuracy of DCEUS in diagnosing EGC, Borrmann I, II and Borrmann (III + IV) was higher than that of MDCT (96% vs 92%; 96% vs 94%; 87% vs 80%; 83% vs 73%), while in determining Borrmann III and IV, that of DCEUS was lower than that of MDCT (72% vs 74%; 89% vs 96%). Conclusion Considering the revolution in clinical decision, prognosis evaluation, safety and non-invasion aspects, DCEUS can be used as the main alternative method for Borrmann classification of GC preoperatively.

Small bowel adenocarcinoma of the jejunum detected by double contrast enhanced ultrasound: a case report of a novel ultrasound modality

“…With injection of 2.5 ml ultrasound contrast agent made from sulphur hexafluoride microbubbles, lesions can be assessed dynamically from the early arterial phase (10–15s) to the late phase (5 min), with no significant effects on thyroid function ( 8 ). Previous research has demonstrated that DCEUS can be a practical substitute for preoperative Borrmann classification of gastric cancer ( 9 ). In this particular case, DCEUS was utilized and successfully detected an SBA in the jejunum.…”

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“…With injection of 2.5 ml ultrasound contrast agent made from sulphur hexafluoride microbubbles, lesions can be assessed dynamically from the early arterial phase (10-15s) to the late phase (5 min), with no significant effects on thyroid function (8). Previous research has demonstrated that DCEUS can be a practical substitute for preoperative Borrmann classification of gastric cancer (9). In this particular case, DCEUS was utilized and successfully detected an SBA in the jejunum.…”