Double clad tubular anti-resonant hollow core fiber for nonlinear microendoscopy

Kudlinski, Alexandre; Cassez, Andy; Vanvincq, Olivier; Septier, D.; Pastre, Aymeric; Habert, Rémi; Baudelle, Karen; Douay, M.; Mytskaniuk, Vasyl; Tsvirkun, Viktor; Rigneault, Hervé; Bouwmans, Géraud

doi:10.1364/oe.389084

Cited by 25 publications

(26 citation statements)

References 32 publications

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“…S1 and S2 ). It is highly stable and can be manufactured at a low cost with high reproducibility, in comparison to alternative hollow-core fibers, which are significantly more difficult to manufacture and have higher attenuation 11 , 24 . The fiber operates in single-mode for two core sizes of 4.8 and 6.3 µm, matching the CARS excitation wavelengths of 795 nm and 1030 nm.…”

Section: Discussionmentioning

confidence: 99%

“…In order to use the same fiber for laser delivery and signal collection, double-clad fibers can be employed 14 , 17 . Hollow-core double-clad fibers have already been realized for coherent Raman endoscopy 11 , 19 , 24 . Hence, when significant power losses within the delivery fiber cannot be tolerated, e.g., when using compact lasers of moderate average power, solid single-mode delivery fibers of small mode field diameter are required.…”

Section: Introductionmentioning

confidence: 99%

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Multimodal nonlinear endomicroscopic imaging probe using a double-core double-clad fiber and focus-combining micro-optical concept

et al. 2021

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Multimodal non-linear microscopy combining coherent anti-Stokes Raman scattering, second harmonic generation, and two-photon excited fluorescence has proved to be a versatile and powerful tool enabling the label-free investigation of tissue structure, molecular composition, and correlation with function and disease status. For a routine medical application, the implementation of this approach into an in vivo imaging endoscope is required. However, this is a difficult task due to the requirements of a multicolour ultrashort laser delivery from a compact and robust laser source through a fiber with low losses and temporal synchronization, the efficient signal collection in epi-direction, the need for small-diameter but highly corrected endomicroobjectives of high numerical aperture and compact scanners. Here, we introduce an ultra-compact fiber-scanning endoscope platform for multimodal non-linear endomicroscopy in combination with a compact four-wave mixing based fiber laser. The heart of this fiber-scanning endoscope is an in-house custom-designed, single mode, double clad, double core pure silica fiber in combination with a 2.4 mm diameter NIR-dual-waveband corrected endomicroscopic objective of 0.55 numerical aperture and 180 µm field of view for non-linear imaging, allowing a background free, low-loss, high peak power laser delivery, and an efficient signal collection in backward direction. A linear diffractive optical grating overlays pump and Stokes laser foci across the full field of view, such that diffraction-limited performance is demonstrated for tissue imaging at one frame per second with sub-micron spatial resolution and at a high transmission of 65% from the laser to the specimen using a distal resonant fiber scanner.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Multimodal nonlinear endomicroscopic imaging probe using a double-core double-clad fiber and focus-combining micro-optical concept

et al. 2021

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“…In the resonant state, light leaks out of the cladding since the resonant cavity can be regarded as transparent. In the non-resonant state, the reflection coefficient of the resonant cavity has a high reflection coefficient, which limits the propagation of light within the core (Kudlinski et al, 2020). It is the flexibility and versatility of the photonic crystal fiber structure improves the output characteristics of lasers, which gives it advantages than the conventional fiber structure.…”

Section: Structure and Light Conduction Mechanism Of Photonic Crystal Fibersmentioning

confidence: 99%

Ion-Doped Photonic Crystal Fiber Lasers

Hou

Xie

et al. 2021

Front. Chem.

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Compared with conventional solid-state lasers, fiber lasers have the advantages of small size, simple cooling system, and good output beam quality, enabling them an extended service lifetime in industrialized environments. Periodically arranged photonic crystals have been the most important gain medium for high-power laser applications, which overcame the problems in fiber lasers such as small mode field, low degree of nonlinearity, and non-adjustable dispersion. In this mini-review, we summarize the recent advances of typical ion-doped photonic crystal fiber lasers doped, discuss the challenges, and provide an outlook on the future developments in ion-doped photonic crystal fiber lasers.

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“…To take full advantage of their properties, several research groups have begun elaborating other hollow-core fiber-integrated optical devices, such as optical fiber couplers [4,5], filters [6] or sensors [7,8], including multiphoton fluorescence optical fiber sensor setups [9,10]. The latter is a very promising area and is already delivering some remarkable results in biological and medical research by employing not only multiphoton-excited fluorescence but also other non-linear phenomena such as, for example, second harmonic generation or coherent anti-stokes Raman scattering [11,12]. However, HCARF-based sensors employing non-linear methods for medical diagnostics up to this day lack one interesting functionality-namely the capability of measuring fluorescence anisotropy.…”

Section: Introductionmentioning

confidence: 99%

Fluorescence Anisotropy Sensor Comprising a Dual Hollow-Core Antiresonant Fiber Polarization Beam Splitter

Stawska

Popenda

2020

Sensors

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Fluorescence anisotropy imaging and sensing is a widely recognized method for studying molecular orientation and mobility. However, introducing this technique to in vivo systems is a challenging task, especially when one considers multiphoton excitation methods. Past two decades have brought a possible solution to this issue in the form of hollow-core antiresonant fibers (HC-ARFs). The continuous development of their fabrication technology has resulted in the appearance of more and more sophisticated structures. One of the most promising concepts concerns dual hollow-core antiresonant fibers (DHC-ARFs), which can be used to split and combine optical signals, effectively working as optical fiber couplers. In this paper, the design of a fluorescence anisotropy sensor based on a DHC-ARF structure is presented. The main purpose of the proposed DHC-ARF is multiphoton-excited fluorescence spectroscopy; however, other applications are also possible.

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Double clad tubular anti-resonant hollow core fiber for nonlinear microendoscopy

Cited by 25 publications

References 32 publications

Multimodal nonlinear endomicroscopic imaging probe using a double-core double-clad fiber and focus-combining micro-optical concept

Multimodal nonlinear endomicroscopic imaging probe using a double-core double-clad fiber and focus-combining micro-optical concept

Ion-Doped Photonic Crystal Fiber Lasers

Fluorescence Anisotropy Sensor Comprising a Dual Hollow-Core Antiresonant Fiber Polarization Beam Splitter

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