Double-bouquet cells in the monkey and human cerebral cortex with special reference to areas 17 and 18

DeFelipe, Javier; Ballesteros-Yáñez, Inmaculada; Inda, Maria Carmen; Muñoz, Alberto

doi:10.1016/s0079-6123(06)54002-6

Cited by 47 publications

(48 citation statements)

References 41 publications

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“…The axon of L2/3 Vip INs is also directed vertically, in a narrow columnar fashion, where their axonal projections often reach L4 and L5/6, in addition to their local axonal arbor (Bayraktar et al, 2000; Porter et al, 1998; Pronneke et al, 2015). These axonal features are reminiscent of what has been described as “horsetail” and double bouquet cells in primates (DeFelipe et al, 2006). Therefore, the direct influence of L2/3 bipolar Vip INs is likely to be vertically broad and laterally restricted.…”

Section: Interneuron Diversity In the Neocortexmentioning

confidence: 60%

GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits

Tremblay

Lee

Rudy

2016

Neuron

1,562

1,810

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Cortical networks are composed of glutamatergic excitatory projection neurons and local GABAergic inhibitory interneurons which gate signal flow and sculpt network dynamics. Although they represent a minority of the total neocortical neuronal population, GABAergic interneurons are highly heterogeneous, forming functional classes based on their morphological, electrophysiological and molecular features as well as connectivity and in vivo patterns of activity. Here we review our current understanding of neocortical interneuron diversity and the properties that distinguish among cell types. We then discuss how the involvement of multiple cell types, each with a specific set of cellular properties, plays a crucial role in diversifying and increasing the computational power of a relatively small number of simple circuit motifs forming cortical networks. We illustrate how recent advances in the field have shed light onto the mechanisms by which GABAergic inhibition contributes to network operations.

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Section: Interneuron Diversity In the Neocortexmentioning

confidence: 60%

GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits

Tremblay

Lee

Rudy

2016

Neuron

1,562

1,810

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“…In the adult primate neocortex, VIP + /CR + GABAergic neurons often exhibit a "horse-tail" morphology (a term that encompasses bitufted, bipolar, and double-bouquet cells) (DeFelipe et al 2013). These cells are characterized by long, vertically oriented axon collaterals that can form hundreds of inhibitory synapses with dendrites of pyramidal cells from several cortical layers (Cajal 1899;DeFelipe et al 2006). This unique morphology is not evident in rodents but is thought to play a critical role in the microcolumnar organization of neocortical circuits in primates (Yanez et al 2005;DeFelipe et al 2006;Jones 2009).…”

Section: Introductionmentioning

confidence: 99%

“…These cells are characterized by long, vertically oriented axon collaterals that can form hundreds of inhibitory synapses with dendrites of pyramidal cells from several cortical layers (Cajal 1899;DeFelipe et al 2006). This unique morphology is not evident in rodents but is thought to play a critical role in the microcolumnar organization of neocortical circuits in primates (Yanez et al 2005;DeFelipe et al 2006;Jones 2009). Because CGE/LGE-derived, VIP + /CR + GABAergic neurons are present in rodent neocortex, these observations suggest that horse-tail neurons in primates represent an elaboration of an existing cell type (as opposed to wholesale creation of a novel cell type; Hansen et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Secretagogin is Expressed by Developing Neocortical GABAergic Neurons in Humans but not Mice and Increases Neurite Arbor Size and Complexity

et al. 2017

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The neocortex of primates, including humans, contains more abundant and diverse inhibitory neurons compared with rodents, but the molecular foundations of these observations are unknown. Through integrative gene coexpression analysis, we determined a consensus transcriptional profile of GABAergic neurons in mid-gestation human neocortex. By comparing this profile to genes expressed in GABAergic neurons purified from neonatal mouse neocortex, we identified conserved and distinct aspects of gene expression in these cells between the species. We show here that the calcium-binding protein secretagogin (SCGN) is robustly expressed by neocortical GABAergic neurons derived from caudal ganglionic eminences (CGE) and lateral ganglionic eminences during human but not mouse brain development. Through electrophysiological and morphometric analyses, we examined the effects of SCGN expression on GABAergic neuron function and form. Forced expression of SCGN in CGE-derived mouse GABAergic neurons significantly increased total neurite length and arbor complexity following transplantation into mouse neocortex, revealing a molecular pathway that contributes to morphological differences in these cells between rodents and primates.

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“…In primary visual cortex (V1), the architecture of Old World monkeys and great apes, including humans, is qualitatively similar, although there are numerous quantitative differences among these species (Horton and Hedley-Whyte, 1984; Preuss et al, 1999; Preuss and Coleman, 2002; DeFelipe et al, 2006). One common characteristic of the visual system across these species is the distribution of the three cone photoreceptors (L-, M-, and S-cones) that feed into the different classes of ganglion cells giving rise to the correspondingly elaborate retino-geniculo-cortical pathway (Leventhal et al, 1981; Livingstone and Hubel, 1988; Kaas and Huerta, 1988; Conley and Fitzpatrick, 1989; Casagrande and Norton, 1991; Casagrande, 1994; Hendry and Yoshioka, 1994).…”

mentioning

confidence: 99%

Distribution of vesicular glutamate transporter 2 (VGluT2) in the primary visual cortex of the macaque and human

García-Marín

Ahmed

Afzal

et al. 2012

J of Comparative Neurology

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The majority of thalamic terminals in V1 arise from lateral geniculate nucleus (LGN) afferents. Thalamic afferent terminals are preferentially labeled by an isoform of the vesicular glutamate transporter, VGluT2. The goal of our study was to determine the distribution of VGluT2-ir puncta in macaque and human visual cortex. First, we investigated the distribution of VGluT2-ir puncta in all layers of macaque monkey primary visual cortex (V1), and found a very close correspondence between the known distribution of LGN afferents from previous studies and the distribution of VGluT2-immunoreactive (-ir) puncta. There was also a close correspondence between cytochrome oxidase density and VGluT2-ir puncta distribution. After validating the correspondence in macaque, we made a comparative study in human V1. In many aspects, the distribution of VGluT2-ir puncta in human was qualitatively similar to that of the macaque: high densities in layer 4C, patches of VGluT2-ir puncta in the supragranular layer (2/3), lower but clear distribution in layers 1 and 6, and very few puncta in layers 5 and 4B. However, there were also important differences between macaques and humans. In layer 4A of human, there was a sparse distribution of VGluT2-ir puncta, whereas in macaque, there was a dense distribution with the characteristic honeycomb organization. The results suggest important changes in the pattern of cortical VGluT2 immunostaining that may be related to evolutionary differences in the cortical organization of LGN afferents between Old World monkeys and humans.

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Double-bouquet cells in the monkey and human cerebral cortex with special reference to areas 17 and 18

Cited by 47 publications

References 41 publications

GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits

GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits

Secretagogin is Expressed by Developing Neocortical GABAergic Neurons in Humans but not Mice and Increases Neurite Arbor Size and Complexity

Distribution of vesicular glutamate transporter 2 (VGluT2) in the primary visual cortex of the macaque and human

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