Double-blinded, randomized, placebo-controlled study to evaluate the effectiveness of sulphasalazine in preventing acute gastrointestinal complications due to radiotherapy

Kılıç, Diclehan; Egehan, Îbrahîm; Özeni̇rler, Seren; Dursun, Ayşe

doi:10.1016/s0167-8140(00)00254-1

Cited by 66 publications

(25 citation statements)

References 14 publications

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“…For examples, glutamine, a non-essential amino acid was widely studied for its potential protective effect on mucositis, dermatitis and oespahagitis [114][115][116][117] ; pentoxifyline, a methyl xanthine derivative, decreased the risk of radiation toxicity in lung [118] ; benzydamine could prevent and treat oral mucositis [119] ; and sulfasalazine was evaluated for its effects on radiotherapy-induced enteritis [120] . To date, there are still a limited number of chemical RAs clinically used to minimize the severity and duration of toxicities associated with radiotherapy.…”

Section: Ra Its Categoris and Mechanisms Of Functionmentioning

confidence: 99%

Research and Development of Radioprotective Agents: A Mini-Review

Saaya

Katsube

Xie

et al. 2017

International Journal of Radiology

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The research and development (R&D) of radioprotective agents (RAs) have been conducting since seven decades ago, and the safety and protection against undesirable effects of ionizing radiation (IR) has become an important issue especially for the benefit of patients receiving the radiotherapy, in addition to the applications in nuclear industry, military, outer space exploration and accidental exposures. Although the technology advancement makes the radiotherapy a promising better treatment by maximizing the effect of IR to the cancer cells, there are still needs for improvement in minimizing the toxicity to the normal cells. Aiming at providing the new researchers in the radiation protection field with an overall view for R&D of the RAs, this mini-review elucidates in brief a general understanding of the IR and its effects on the cell, the concepts of radiotherapy and therapeutic ratio, the categories of RAs and their mechanisms, and discusses on the strategies and challenge for R&D of the RAs.

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Section: Ra Its Categoris and Mechanisms Of Functionmentioning

confidence: 99%

Research and Development of Radioprotective Agents: A Mini-Review

Saaya

Katsube

Xie

et al. 2017

International Journal of Radiology

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“…Some authors have investigated the effects of sulfasalazine and its active component, 5-aminosalicylic acid (5-ASA), in the prevention of acute radiation toxicity. The results from previous studies of 5-ASA and its precursors have been controversial [12][13][14][15][16][17][18][19]. The combination of oral and topical 5-ASA may produce a better response in the management of mild to moderate distal colitis than administration of the oral or topical formulation alone [20].…”

Section: Introductionmentioning

confidence: 99%

The Efficacy of the Combination Therapy with Oral and Topical Mesalazine for Patients with the First Episode of Radiation Proctitis

et al. 2011

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“…Our efforts should therefore focus on prevention, either with medication that protects against radiation or anti-inflammatory treatment (16). Also helpful would be the use of absorbable mesh slings which separate the intestine from the field of radiation (17).…”

Section: Discussionmentioning

confidence: 99%

“…Nuestros esfuerzos deberán centrarse, por lo tanto, en la prevención ya sea con radioprotectores o antiinflamatorios (16), o usando mallas reabsorbibles que alejen el intestino del campo de la radiación (17). Nuestra paciente rechazó el tratamiento quirúrgico una vez se llegó al diagnóstico.…”

Section: Discussionunclassified

Obscure gastrointestinal bleeding: a complication of radiation enteritis diagnosed by wireless capsule endoscopy

Ares

Conde

Ruzo

et al. 2004

Rev. esp. enferm. dig.

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Obscure gastrointestinal bleeding is a common disorder and may account for as many as 5% of all gastrointestinal hemorrhages. It is often caused by lesions in the small intestine, which were very complicated to examine prior to the advent of wireless capsule endoscopy.Here we present the case of a 31-year-old woman with obscure gastrointestinal bleeding as a complication of radiation enteritis, which was diagnosed only after she underwent an examination with wireless capsule endoscopy.This technique has proven to be far superior to other radiographic and endoscopic methods in diagnosing obscure gastrointestinal bleeding and pathologies of the small intestine in general.

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Double-blinded, randomized, placebo-controlled study to evaluate the effectiveness of sulphasalazine in preventing acute gastrointestinal complications due to radiotherapy

Cited by 66 publications

References 14 publications

Research and Development of Radioprotective Agents: A Mini-Review

Research and Development of Radioprotective Agents: A Mini-Review

The Efficacy of the Combination Therapy with Oral and Topical Mesalazine for Patients with the First Episode of Radiation Proctitis

Obscure gastrointestinal bleeding: a complication of radiation enteritis diagnosed by wireless capsule endoscopy

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