Double blind study of ispaghula in irritable bowel syndrome.

Prior, Alison; Whorwell, Peter J.

doi:10.1136/gut.28.11.1510

Cited by 128 publications

(68 citation statements)

References 9 publications

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“…The study of Prior and PJ Whorwell 19 suggests that Ispaghula is useful in relieving constipation and improving well being in patients with IBS but is no more effective than placebo in relieving abdominal pain & distension.…”

Section: Discussionmentioning

confidence: 99%

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Effect of Ispaghula and Oxyphenonium Bromide on the Symptoms of Irritable Bowel Syndrome - A Comparative Study

Paik¹,

Sk²,

Masud³

et al. 2010

Bangabandhu Sheikh Mujib Medical Univ J

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Abstract:Background: Irritable bowel syndrome is a chronic continuous or remittent gastrointestinal illness characterized by frequent unexplained symptoms that include abdominal pain, bloating, and bowel disturbance, in our country, no study has been conducted using the Ispaghula husk and oxyphenonium bromide for the treatment of IBS patients. Objectives: To compare the efficacy of treatment with Ispaghula husk and Oxyphenonium bromide. Methods: Total sixty patients diagnosed clinically as irritable bowel syndrome irrespective of subtype who fulfilled the Rome II criteria were included equally into two groups-Group-I (Ispaghula group) & Group-II (Oxyphenonium group). In Group-I patients were given 30gm of Ispaghula husk at night daily and in Group-II patients were given 5mg of oxyphenonium bromide. After six weeks the clinical parameters of both the groups recorded in the case record forms were taken for analysis. Results: The mean age of the patients in the Group-I were 33.4±11.9 yrs and that of the patients in the Group-II were 31.0±17.5 yrs. Male and female ratio in group I was 14:1 and in group II was 23:7. Most of the patients were recorded in the age group of 26-30 in both groups . Symptom free patients were graded in 16.7% patients in Group-I and in 20% patients in Group-II. No improvement was occurred in 16.7% patients in Group-I and in 10% patients in Group-II. Conclusions: Ispaghula husk shows the better efficacy to improve the symptoms of IBS like abdominal pain or discomfort and sense of well being than Oxyphenonium bromide. Oxephenonium bromide shows the better efficacy to decrease the stool frequency from base line than Ispaghula husk.

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Section: Discussionmentioning

confidence: 99%

“…15 The efficacy of the Ispaghula husk and anticholicnergies in the treatment of IBS have been evaluated in different studies. [16][17][18][19][20] Global IBS symptoms were improved in patient taking ispaghula husk. In these studies subgroup analysis of specific symptoms noted that abdominal pain was not improved.…”

Section: Original Articlesmentioning

confidence: 99%

Effect of Ispaghula and Oxyphenonium Bromide on the Symptoms of Irritable Bowel Syndrome - A Comparative Study

Paik¹,

Sk²,

Masud³

et al. 2010

Bangabandhu Sheikh Mujib Medical Univ J

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“…Interestingly, the correlation between aggregate measures of published studies addressing bowel patterns and pain correspond with results of a pilot study, which demonstrated a significant relationship between changes in bowel frequency and pain ratings for individual patients receiving linaclotide for constipation. 62 The described correlation between improved pain ratings were not only reported in studies of the newly introduced agents for IBS-C, [63][64][65][66][67] but were also observed in many other trials, which did not meet inclusion criteria for this analysis and examined the effects of interventions ranging from fiber supplements, 68,69 to herbal preparations, 70 biofeedback, 71 bisacodyl, 72 or osmotic laxatives. [73][74][75] While not the focus of this analysis, we noted some statistically significant, but clinically minor, differences in the endpoints between patient cohorts with constipation and IBS-C.…”

Section: Discussionmentioning

confidence: 99%

Effective Constipation Treatment Changes More Than Bowel Frequency: A Systematic Review and Meta-Analysis

Bielefeldt

Levinthal

Nusrat

2015

J Neurogastroenterol Motil

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Background/AimsThe marketing of newer agents for treatment of constipation and irritable bowel syndrome with constipation (IBS-C) emphasize improvements in abdominal pain. However, it is not clear whether this observation reflects a unique visceral analgesic effect of these agents or is a general feature of effective laxation. We sought to determine the relationship between improvements in bowel frequency and decreases in abdominal pain in clinical trials of patients with constipation or IBS-C. MethodsWe searched "PubMed" and "Embase" databanks for clinical trials in patients with constipation or IBS-C, targeting publications that provided detailed data on bowel movement frequency and pain intensity before and after an intervention. We abstracted the results and performed meta-analytic and meta-regression analyses. Results Twenty

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“…They illustrate the difficulty of establishing an objective physiological treatment for functional bowel conditions, but they perhaps also provide an explanation for the commercial success of products that, although they may lack any established mechanism of action, are both enjoyed by consumers and perceived by them as beneficial to gastrointestinal health. Unlike cereal brans, there is some evidence for a specific beneficial effect of isphagula husk in IBS patients (Prior & Whorwell, 1987). This material is a complex source of dietary fibre, rich in both soluble and insoluble polysaccharides, some of which resist bacterial degradation in the colon.…”

Section: Irritable Bowel Syndromementioning

confidence: 99%

New food components and gastrointestinal health

Johnson

2001

Proc. Nutr. Soc.

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Apart from its main functions of digestion, absorption and faecal processing, the human gastrointestinal tract has a complex pattern of muscular activity regulated by a largely autonomous nervous system, and its various organs contain large concentrations of immune and endocrine tissues. Any failure of these closely-integrated systems can lead to diseases ranging from the mildly irritating to the life threatening. Food contains a huge variety of chemical species, many of which are biologically active, and the distal regions of the gut are colonised by a rich and metabolically-active commensal flora that depend on nutrients derived ultimately from the host’s dietary residues. The present paper explores the evidence for significant effects of food ingredients on functional bowel disorders, intestinal infections, and aspects of epithelial cell physiology involved in the development of colo-rectal neoplasia. Various strategies, including the manipulation of the colo-rectal microflora with pre- and probiotics, and the development of new products and plant varieties containing biologically-active constituents, have the potential to underpin the development of novel functional food products. However, these products will need to be based on proven biological principles, and fully tested for efficacy and safety. The rapidly-developing fields of functional genomics and cell biology will open up new experimental strategies to explore these possibilities, and emerging processing technologies seem likely to provide novel methods for their exploitation.

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Double blind study of ispaghula in irritable bowel syndrome.

Cited by 128 publications

References 9 publications

Effect of Ispaghula and Oxyphenonium Bromide on the Symptoms of Irritable Bowel Syndrome - A Comparative Study

Effect of Ispaghula and Oxyphenonium Bromide on the Symptoms of Irritable Bowel Syndrome - A Comparative Study

Effective Constipation Treatment Changes More Than Bowel Frequency: A Systematic Review and Meta-Analysis

New food components and gastrointestinal health

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