Double-blind, right/left comparison of calcipotriol and betamethasone valerate in treatment of psoriasis vulgaris

Kragballe, Knud; Gjertsen, Bjørn T.; Hoop, D. de; Karlsmark, Tonny; Kerkhof, P.C.M.; Larkö, Olle; Nieboer, C.; Roed-Petersen, J; Strand, Anders; Tikjøb, G

doi:10.1016/0140-6736(91)92157-w

Cited by 329 publications

(155 citation statements)

References 14 publications

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“…Calci is an analogue of vitamin D used for the treatment of chronic plaque psoriasis and has minimal effects on calcium metabolism. The therapeutic efficacy of Calci has been demonstrated in numerous clinical studies [6]. BD belongs to the class of adrenocortical steroid and used as topicalcorticosteroid in treatment of different skin disorders.…”

Section: Introductionmentioning

confidence: 99%

Stability Indicating RP-HPLC Method for Estimation of Impurities of Vitamin D<sub>3</sub> Analogue and Corticosteroid Used as Antipsoriatic Drugs. An Attempt to Characterize Pre-Calcipotriene

Bhogadi

Satyanarayana²,

Rao³

et al. 2015

AJAC

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A single RP-HPLC method is developed for estimation of isomeric impurities of vitamin D3 analogueCalcipotriol/Calcipotriene (Calci) and impurities of Betamethasone dipropionate (BD). The developed method is capable of separating impurities of Calci and BD, specifically pre-Calcipotriene (Pre-Calci) from other known and unknown impurities. Pre-Calci is isolated and is characterised using few analytical techniques. These impurities are separated using a RP-C18 150 × 4.6 mm, 2.7 µm column maintained at 50˚C. The mobile phase consisted of mixture of water, methanol, acetonitrile and tetrahydrofuran eluted in gradient mode. Detection was done at 264 nm and 240 nm for Calci and BD impurities respectively. The method can be used for determining quality of Calci and BD drugs and ointment based drug products. It is stability indicating related substance method for both the drugs and drug products.

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Section: Introductionmentioning

confidence: 99%

Stability Indicating RP-HPLC Method for Estimation of Impurities of Vitamin D<sub>3</sub> Analogue and Corticosteroid Used as Antipsoriatic Drugs. An Attempt to Characterize Pre-Calcipotriene

Bhogadi

Satyanarayana²,

Rao³

et al. 2015

AJAC

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“…The short-term adverse effect of topical vitamin D is minimal if present and consists of only minor facial dermatitis. Calcium level alterations were not seen in any studies [32][33][34]. Long-term safety and efficacy studies have also demonstrated efficacy and an excellent safety profile for topical tacalcitol [35][36][37].…”

Section: Vitamin Dmentioning

confidence: 99%

Psoriasis and Fat-soluble Vitamins: A Review

Usedom¹,

Neidig²,

Allen³

2017

J Clin Exp Dermatol Res

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Fat-soluble vitamins exhibit numerous routes of immune modulation and specifically alter a variety of pathways in psoriasis pathology. Psoriasis, a chronic immune-mediated disease, often requires a combination of topical, oral, and occasionally, subcutaneous or intravenous therapies making disease management complex. With the complexity of treatment, patient adherence is reduced. Vitamin supplementation as an adjunctive treatment would minimize potential adverse effects from systemic medication, increase patient adherence and decrease overall cost. While vitamin A and D are effective topically, oral supplementation is not currently a mainstay of therapy although data exists to support such supplementation. Data on vitamin E and K implicate the significant role each has in the alteration of the inflammatory cascade responsible for psoriasis. Research showing fat-soluble vitamin deficiency in psoriasis exists and presents greater evidence for oral vitamin treatment in addition to first-line therapies. This review presents the mechanism of action in psoriasis of each fat-soluble vitamin and the data on the efficacy of oral fat-soluble vitamin supplementation in psoriasis and systemic inflammation. We also present fat-soluble vitamin deficiency data shown in psoriasis patients. With the evidence of their targeted mechanism of action, efficacy data with oral supplementation, and evidence of deficiency in patients, oral fat-soluble vitamins should be considered as an adjunct to therapy in psoriasis patients.

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“…Topical calcipotriol (0.005%) is found more effective than the conventional topical corticosteroid (betamethasone 0.1%) in some studies. [12][13][14] An effective therapeutic options for plaque psoriasis is limited & the results are somewhat not satisfactory to some extent. Therefore the purpose of the present study was to compare the efficacy level of topical calciprotriol (0.005%) and topical corticosteroid (betamethasone 0.1%) in plaque type psoriasis in Bangladesh.…”

Section: Originalmentioning

confidence: 99%

Comparative Efficacy of Topical Calcipotriol (0.005%) Versus Topical Corticosteroid (Betamethasone 0.1%) in Treating Plaque Type Psoriasis

Ahmed

Khandker

Nessa³

et al. 2015

Med. Today

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Double-blind, right/left comparison of calcipotriol and betamethasone valerate in treatment of psoriasis vulgaris

Cited by 329 publications

References 14 publications

Stability Indicating RP-HPLC Method for Estimation of Impurities of Vitamin D<sub>3</sub> Analogue and Corticosteroid Used as Antipsoriatic Drugs. An Attempt to Characterize Pre-Calcipotriene

Stability Indicating RP-HPLC Method for Estimation of Impurities of Vitamin D<sub>3</sub> Analogue and Corticosteroid Used as Antipsoriatic Drugs. An Attempt to Characterize Pre-Calcipotriene

Psoriasis and Fat-soluble Vitamins: A Review

Comparative Efficacy of Topical Calcipotriol (0.005%) Versus Topical Corticosteroid (Betamethasone 0.1%) in Treating Plaque Type Psoriasis

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Double-blind, right/left comparison of calcipotriol and betamethasone valerate in treatment of psoriasis vulgaris

Cited by 329 publications

References 14 publications

Stability Indicating RP-HPLC Method for Estimation of Impurities of Vitamin D&lt;sub&gt;3&lt;/sub&gt; Analogue and Corticosteroid Used as Antipsoriatic Drugs. An Attempt to Characterize Pre-Calcipotriene

Stability Indicating RP-HPLC Method for Estimation of Impurities of Vitamin D&lt;sub&gt;3&lt;/sub&gt; Analogue and Corticosteroid Used as Antipsoriatic Drugs. An Attempt to Characterize Pre-Calcipotriene

Psoriasis and Fat-soluble Vitamins: A Review

Comparative Efficacy of Topical Calcipotriol (0.005%) Versus Topical Corticosteroid (Betamethasone 0.1%) in Treating Plaque Type Psoriasis

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Product

Resources

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Stability Indicating RP-HPLC Method for Estimation of Impurities of Vitamin D<sub>3</sub> Analogue and Corticosteroid Used as Antipsoriatic Drugs. An Attempt to Characterize Pre-Calcipotriene

Stability Indicating RP-HPLC Method for Estimation of Impurities of Vitamin D<sub>3</sub> Analogue and Corticosteroid Used as Antipsoriatic Drugs. An Attempt to Characterize Pre-Calcipotriene