Double-blind Randomized Trial of t-DCS Versus Sham in Parkinson Patients With Mild Cognitive Impairment Receiving Cognitive Training

Biundo, Roberta; Weis, Luca; Fiorenzato, Eleonora; Gentile, Giovanni; Giglio, Manuela; Schifano, Roberta; Campo, Maria Concetta; Marcon, Vanessa; Martinez‐Martín, Pablo; Bisiacchi, Patrizia; Antonini, Angelo

doi:10.1016/j.brs.2015.07.043

Cited by 66 publications

(73 citation statements)

References 10 publications

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“…One low‐quality, exploratory study evaluated cognitive rehabilitation for improving cognitive impairment in PD patients receiving computer‐based cognitive training; some significant effects were reported. Because of the exploratory character of the study and the small sample size, the efficacy conclusion is “ insufficient evidence .” Because of the limited data available for MCI in PD, the practice implication is “ investigational .” Because of the lack of safety data, there is “ insufficient evidence ” to conclude on the safety of cognitive rehabilitation for cognitive impairment in PD.…”

Section: Results and Conclusionmentioning

confidence: 99%

“…the exploratory character of the study and the small sample size, the efficacy conclusion is "insufficient evidence." Because of the limited data available for MCI in PD, 34 the practice implication is "investigational." Because of the lack of safety data, 34,89 there is "insufficient evidence" to conclude on the safety of cognitive rehabilitation for cognitive impairment in PD.…”

Section: R E a T M E N T O F T H E N O N M O T O R S Y M P T O M S I mentioning

confidence: 99%

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Update on treatments for nonmotor symptoms of Parkinson's disease—an evidence‐based medicine review

et al. 2019

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Objective To update evidence‐based medicine recommendations for treating nonmotor symptoms in Parkinson's disease (PD). Background The International Parkinson and Movement Disorder Society Evidence‐Based Medicine Committee's recommendations for treatments of PD were first published in 2002, updated in 2011, and now updated again through December 31, 2016. Methods Level I studies testing pharmacological, surgical, or nonpharmacological interventions for the treatment of nonmotor symptoms in PD were reviewed. Criteria for inclusion and quality scoring were as previously reported. The disorders covered were a range of neuropsychiatric symptoms, autonomic dysfunction, disorders of sleep and wakefulness, pain, fatigue, impaired olfaction, and ophthalmologic dysfunction. Clinical efficacy, implications for clinical practice, and safety conclusions are reported. Results A total of 37 new studies qualified for review. There were no randomized controlled trials that met inclusion criteria for the treatment of anxiety disorders, rapid eye movement sleep behavior disorder, excessive sweating, impaired olfaction, or ophthalmologic dysfunction. We identified clinically useful or possibly useful interventions for the treatment of depression, apathy, impulse control and related disorders, dementia, psychosis, insomnia, daytime sleepiness, drooling, orthostatic hypotension, gastrointestinal dysfunction, urinary dysfunction, erectile dysfunction, fatigue, and pain. There were no clinically useful interventions identified to treat non‐dementia‐level cognitive impairment. Conclusions The evidence base for treating a range of nonmotor symptoms in PD has grown substantially in recent years. However, treatment options overall remain limited given the high prevalence and adverse impact of these disorders, so the development and testing of new treatments for nonmotor symptoms in PD remains a top priority. © 2019 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

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Section: Results and Conclusionmentioning

confidence: 99%

Section: R E a T M E N T O F T H E N O N M O T O R S Y M P T O M S I mentioning

confidence: 99%

Update on treatments for nonmotor symptoms of Parkinson's disease—an evidence‐based medicine review

et al. 2019

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“…Two independent studies in PD with MCI modulating the DLPFC however showed contrasting results. Biundo et al [112] did not report improvements in executive functions after atDCS combined with cognitive training. In contrast, Manenti et al [114], testing 2 weeks of atDCS combined with physical training, observed significant improvement of the Parkinson’s disease cognitive rating test and verbal fluency, with a significant effect also at follow-up [114].…”

Section: Nibs and Dementiamentioning

confidence: 99%

Non-Invasive Brain Stimulation in Dementia: A Complex Network Story

et al. 2018

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Non-invasive brain stimulation (NIBS) is emerging as a promising rehabilitation tool for a number of neurodegenerative diseases. However, the therapeutic mechanisms of NIBS are not completely understood. In this review, we will summarize NIBS results in the context of brain imaging studies of functional connectivity and metabolites to gain insight into the possible mechanisms underlying recovery. We will briefly discuss how the clinical manifestations of common neurodegenerative disorders may be related with aberrant connectivity within large-scale neural networks. We will then focus on recent studies combining resting-state functional magnetic resonance imaging with NIBS to delineate how stimulation of different brain regions induce complex network modifications, both at the local and distal level. Moreover, we will review studies combining magnetic resonance spectroscopy and NIBS to investigate how microscale changes are related to modifications of large-scale networks. Finally, we will re-examine previous NIBS studies in dementia in light of this network perspective. A better understanding of NIBS impact on the functionality of large-scale brain networks may be useful to design beneficial treatments for neurodegenerative disorders.

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“…Finally, non-pharmacological interventions may be beneficial in distinct patient subgroups, including exercise, cognitive training, non-invasive brain stimulation methods, and other techniques to enhance angiogenesis, synaptic plasticity, and neurogenesis [173][174][175][176][177][178]. This is an exciting and developing field, although it is beyond the scope of this brief review.…”

Section: Treatmentmentioning

confidence: 99%

Current treatment of behavioral and cognitive symptoms of Parkinson's disease

Rektorová

2019

Parkinsonism & Related Disorders

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Cognitive and behavioral symptoms are common in Parkinson's disease, may occur even in the prodromal stages of the disease, worsen with disease progression, and surpass motor symptoms as the major factors affecting patient quality of life and caregiver burden. The symptoms may be caused by the disease pathology or they may represent adverse effects of treatment, or both etiological factors may contribute. Although many of these symptoms are related to dopaminergic dysfunction or dopaminergic medication, other neurotransmitters are involved as well. Behavioral symptoms including impulse control disorders, apathy, psychosis, as well as mild cognitive impairment and dementia are reviewed with a special focus on current treatment approaches.

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Double-blind Randomized Trial of t-DCS Versus Sham in Parkinson Patients With Mild Cognitive Impairment Receiving Cognitive Training

Cited by 66 publications

References 10 publications

Update on treatments for nonmotor symptoms of Parkinson's disease—an evidence‐based medicine review

Update on treatments for nonmotor symptoms of Parkinson's disease—an evidence‐based medicine review

Non-Invasive Brain Stimulation in Dementia: A Complex Network Story

Current treatment of behavioral and cognitive symptoms of Parkinson's disease

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