Double-blind, randomized, crossover trial of nabilone vs. placebo in cancer chemotherapy

Wada, Jerry K.; Bogdon, Donald L.; Gunnell, John C.; Hum, Gilbert J.; Gota, Cary H.; Rieth, Tanya E.

doi:10.1016/s0305-7372(82)80034-0

Cited by 38 publications

(21 citation statements)

References 1 publication

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“…In four placebo controlled crossover trials preference for placebo was between 4% and 22%. 28 47 50 61 The difference in favour of cannabinoids was significant (table 2). In 14 active controlled crossover trials 3% to 46% of patients preferred the standard antiemetic.…”

Section: Resultsmentioning

confidence: 96%

Cannabinoids for control of chemotherapy induced nausea and vomiting: quantitative systematic

Tramèr

Carroll²,

Campbell³

et al. 2001

BMJ

516

264

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Section: Resultsmentioning

confidence: 96%

Cannabinoids for control of chemotherapy induced nausea and vomiting: quantitative systematic

Tramèr

Carroll²,

Campbell³

et al. 2001

BMJ

516

264

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show abstract

“…Four trials that have shown nabilone to be effective in treating chemotherapyrelated nausea and vomiting used a higher multi-dose regimen. [26][27][28][29] Patients received the first dose the night before the chemotherapy and the second and third doses before and after chemotherapy. Also, the drug doses (all used 2-mg doses) were higher than in our study.…”

Section: Discussionmentioning

confidence: 99%

A randomized-controlled trial of nabilone for the prevention of acute postoperative nausea and vomiting in elective surgery

Levin

Dulberg

Chan

et al. 2017

Can J Anesth/J Can Anesth

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“…Neidhart et al (1981); Sallan et al (1975) 3 studies The studies exposed dichotomic data on the partial anti-emetic efficacy, not total. Jones et al (1982); Levitt (1982); Wada et al (1982) 1 study…”

Section: Number Of Studies Reasonsmentioning

confidence: 99%

Therapeutic use ofCannabis sativaon chemotherapy-induced nausea and vomiting among cancer patients: systematic review and meta-analysis

Rocha

Stefano

Haiek

et al. 2008

European Journal of Cancer Care

205

115

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This paper aims to evaluate the anti-emetic efficacy of cannabinoids in cancer patients receiving chemotherapy using a systematic review of literature searched within electronic databases such as PUBMED, EMBASE, PSYCINFO, LILACS, and 'The Cochrane Collaboration Controlled Trials Register'. Studies chosen were randomized clinical trials comprising all publications of each database until December 2006. From 12 749 initially identified papers, 30 fulfilled the inclusion criteria for this review, with demonstration of superiority of the anti-emetic efficacy of cannabinoids compared with conventional drugs and placebo. The adverse effects were more intense and occurred more often among patients who used cannabinoids. Five meta-analyses were carried out: (1) dronabinol versus placebo [n=185; relative risk (RR)=0.47; confidence interval (CI)=0.19-1.16]; (2) Dronabinol versus neuroleptics [n=325; RR=0.67; CI=0.47-0.96; number needed to treat (NNT)=3.4]; (3) nabilone versus neuroleptics (n=277; RR=0.88; CI=0.72-1.08); (4) levonantradol versus neuroleptics (n=194; RR=0.94; CI=0.75-1.18); and (5) patients' preference for cannabis or other drugs (n=1138; RR=0.33; CI=0.24-0.44; NNT=1.8). The superiority of the anti-emetic efficacy of cannabinoids was demonstrated through meta-analysis.

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Double-blind, randomized, crossover trial of nabilone vs. placebo in cancer chemotherapy

Cited by 38 publications

References 1 publication

Cannabinoids for control of chemotherapy induced nausea and vomiting: quantitative systematic

Cannabinoids for control of chemotherapy induced nausea and vomiting: quantitative systematic

A randomized-controlled trial of nabilone for the prevention of acute postoperative nausea and vomiting in elective surgery

Therapeutic use ofCannabis sativaon chemotherapy-induced nausea and vomiting among cancer patients: systematic review and meta-analysis

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