Double-blind, randomised, placebo-controlled study to evaluate the efficacy and safety of a fixed combination containing two plant extracts (Crataegus oxyacantha and Eschscholtzia californica) and magnesium in mild-to-moderate anxiety disorders

Hanus, Michel; Lafon, Jacqueline; Mathieu, M.

doi:10.1185/030079903125002603

Cited by 93 publications

(53 citation statements)

References 8 publications

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“…A large randomized controlled trial (RCT) found that a combination of Crataegus oxyacantha (hawthorn), Eschscholzia californica (Californian poppy) and magnesium was more effective than placebo in reducing anxiety in 264 individuals with generalised anxiety disorder (Hanus et al, 2004). Another study evaluated for the central effects of the phytotherapeutic product-CPV (dry extract of Crataegus oxyacantha, Passiflora incarnata and Valeriana officinalis) in animals models.…”

Section: Crataegus In Anxiety and Depressionmentioning

confidence: 99%

See 1 more Smart Citation

The genus Crataegus: chemical and pharmacological perspectives

Kumar¹,

Arya²,

Bhat³

et al. 2012

Rev. bras. farmacogn.

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Abstract:Traditional drugs have become a subject of world importance, with both medicinal and economical implications. A regular and widespread use of herbs throughout the world has increased serious concerns over their quality, safety and efficacy. Thus, a proper scientific evidence or assessment has become the criteria for acceptance of traditional health claims. Plants of the genus Crataegus, Rosaceae, are widely distributed and have long been used in folk medicine for the treatment of various ailments such as heart (cardiovascular disorders), central nervous system, immune system, eyes, reproductive system, liver, kidney etc. It also exhibits wide range of cytotoxic, gastroprotective, anti-inflammatory, anti-HIV and antimicrobial activities. Phytochemicals like oligomeric procyanidins, flavonoids, triterpenes, polysaccharides, catecholamines have been identified in the genus and many of these have been evaluated for biological activities. This review presents comprehensive information on the chemistry and pharmacology of the genus together with the traditional uses of many of its plants. In addition, this review discusses the clinical trials and regulatory status of various Crataegus plants along with the scope for future research in this aspect.

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Section: Crataegus In Anxiety and Depressionmentioning

confidence: 99%

“…Crataegus showed high antioxidant and immunostimulating activity (Li et al, 2009). Crataegus is also employed in CNS disorders like anxiety and mild depression (Hanus et al, 2004).…”

Section: Congestive Heart Failurementioning

confidence: 99%

The genus Crataegus: chemical and pharmacological perspectives

Kumar¹,

Arya²,

Bhat³

et al. 2012

Rev. bras. farmacogn.

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“…Parmi les alcaloïdes, la californine est métabolisée de manière extensive par N-déméthylation et par simple ou double déméthylènisation, suivie de catéchol-O-méthylation. La protopine subit uniquement Eschscholzxanthine, anhydro-eschscholzxanthine, 5-retro-β, β-carotene-3,5,3'-triol [8,14] …”

Section: Absorption Métabolisme Et Excrétionunclassified

Pavot jaune de Californie Eschschol(t)zia californica Cham. (Papaveraceae)

Ghédira¹,

Goetz²,

Jeune³

2010

Phytothérapie

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“…4,5 It is also used in some other critical disease such as control of central nervous system (CNS), anxiety and depression. 6 A Homeopathic medicine has also been prepared from its flowers and fruits by Homeopathic pharmacopeia of India. 7 As food for heart has described.…”

Section: Introductionmentioning

confidence: 99%

Standardization of Agrotechniques and Biochemical Assessment of Crataegus oxyacantha in Western Himalaya

Gopichand¹,

Meena²,

Kaur³

et al. 2017

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C. oxyacantha is a high valued medicinal plant of Rosacea family. It is used to cure cardiac disorder in ayurvedic medicines. A field experiment was laid out in 2004 in CSIR-IHBT farm, by using different quantity of FYM and various spacing. Low growth in plant height was observed in first five years with higher dose of FYM, but in 2015 the significant height growth was recorded. From 2008 to 2015 all types of FYM applications produced statistically significant yield of seed production except in 2012 and 2014. The 22.50t/ha was the most statistically significant dose of FYM in relation to seed yield. The spacing did not produce any significant results for seed production. A vegetative propagation trial of C. oxyacantha was also laid out using semi hard stem cuttings and some selected hormones (IAA, IBA, GA 3 and Abscisic acid) with different concentrations. Statistically significant shoot sprouting (78.35%) was recorded when IBA of 1000 mg/L was used followed by 67.74% in case of 1500 mg/L of the same hormone. While lowest shoot sprouting (27.85%) was observed using 2000 mg/L of Abscisic acid. A statistically significant 5.67 cm and 5.33 cm shoot lengths were observed using 2000 mg/L of IAA and 1000 mg/L of IBA, respectively. In the case of shoot tillers 3.33 was recorded in 1500 mg/l. of IAA. Two new compounds and 9 known compounds were isolated from fruit extract.

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Double-blind, randomised, placebo-controlled study to evaluate the efficacy and safety of a fixed combination containing two plant extracts (Crataegus oxyacantha and Eschscholtzia californica) and magnesium in mild-to-moderate anxiety disorders

Cited by 93 publications

References 8 publications

The genus Crataegus: chemical and pharmacological perspectives

The genus Crataegus: chemical and pharmacological perspectives

Pavot jaune de Californie Eschschol(t)zia californica Cham. (Papaveraceae)

Standardization of Agrotechniques and Biochemical Assessment of Crataegus oxyacantha in Western Himalaya

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