Double-Blind Provocation Chamber Challenges in 20 Patients Presenting with "Multiple Chemical Sensitivity"

Staudenmayer, Herman; Selner, John C.; Buhr, M

doi:10.1006/rtph.1993.1043

Cited by 90 publications

(47 citation statements)

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“…It was not present for saline when the pretreatment had involved active drug in a home environment, or saline in either home or novel environment. These latter observations may affect the interpretation of studies such as those of Staudenmayer et al (103), who reported an unreliable pattern of MCS patient symptom data in differentiating chemical from sham challenges. The within-subjects design and the pretesting of masking odors to determine initial lack of reactivity in that study may have initiated a sensitization process to the testing procedures or the masking odors in the MCS patients.…”

Section: Time-dependent Sensitizationmentioning

confidence: 98%

Individual differences in neural sensitization and the role of context in illness from low-level environmental chemical exposures.

Bell

Schwartz

Baldwin

et al. 1997

Environ Health Perspect

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Section: Time-dependent Sensitizationmentioning

confidence: 98%

Individual differences in neural sensitization and the role of context in illness from low-level environmental chemical exposures.

Bell

Schwartz

Baldwin

et al. 1997

Environ Health Perspect

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“…To date, studies in this area have failed to unmask patients before challenge. When false positive and false negative responses occurred, investigators concluded that chemical sensitivity was psychogenic in origin (32,33).…”

Section: Resultsmentioning

confidence: 99%

Toxicant-induced loss of tolerance--an emerging theory of disease?

Miller

1997

Environ Health Perspect

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“…Definitive research on controlled challenge procedures using appropriate controls is necessary before these procedures can be recommended as tools for diagnosis (39)(40)(41).…”

Section: Discussionmentioning

confidence: 99%

A 37-Year-Old Mechanic with Multiple Chemical Sensitivities

Kipen¹,

Fiedler²

2000

Environmental Health Perspectives

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A 37-year-old heating, ventilation, and air-conditioning mechanic developed respiratory, musculoskeletal, and central nervous system symptoms associated with a variety ofodorous environmental chemicals. Organic disease was not evident, but the patient was distressed by these symptoms and was at risk for becoming disabled by them. His symptoms fit broadly into the condition recognized as multiple chemical sensitivity. Multiple We recommended a methacholine challenge, which was declined by the patient; we also recommended counseling to improve his understanding of and his response to his symptoms. We informed the patient that we did not feel he was disabled and that he could continue to work using a respirator as required. We informed his employer that he was able to use a respirator, and should be permitted to wear one on the job at his own discretion.

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Double-Blind Provocation Chamber Challenges in 20 Patients Presenting with "Multiple Chemical Sensitivity"

Cited by 90 publications

References 0 publications

Individual differences in neural sensitization and the role of context in illness from low-level environmental chemical exposures.

Individual differences in neural sensitization and the role of context in illness from low-level environmental chemical exposures.

Toxicant-induced loss of tolerance--an emerging theory of disease?

A 37-Year-Old Mechanic with Multiple Chemical Sensitivities

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