Double-blind, placebo-controlled study of sublingual immunotherapy in patients with latex-induced urticaria: a 12-month study

Abstract

This is the first double-blind, placebo-controlled evaluation of the efficacy of SLIT with latex extract conducted in adult patients allergic to NRL. SLIT with latex can be proposed for subjects with latex allergy, especially those for whom complete avoidance of latex exposure may be very difficult or even impossible. More studies are needed to evaluate the efficacy of SLIT in the treatment of subjects with latex allergy who are sensitized to inhalant allergens.

Sublingual immunotherapy for large local reactions caused by honeybee sting: A double-blind, placebo-controlled trial

“…In fact, in the recent literature some studies proposed the possible use of SLIT in conditions such as atopic dermatitis, 14 food allergy, 15 or latex allergy. 16 Despite this, no attempt has been made thus far to use SLIT in HVA, and for this reason, we designed a proof-of-concept clinical trial to assess the potential effects of SLIT. Because of the complete absence of literature on the subject, we had to balance the need for a clear demonstration (or refutation) of the clinical effect and the ethical concerns that usually appear in HVA studies.…”

Sublingual immunotherapy: what have we learnt from the ‘big trials’?

“…Recent developments beyond the scope of the present review include the publication of phase II trials of sublingual immunotherapy for potential novel indications: Japanese cedar [34], cat [35] and latex allergy [36] and evaluation of a house dust mite extract in mite-allergic adults [37] and children [38] with atopic dermatitis. A successful trial of sublingual bee venom extract in the treatment of IgE-associated large local reactions provided 'proof of principle' for a possible therapeutic application in venom sting anaphylaxis [39 ].…”

Developments in allergen‐specific immunotherapy: from allergen extracts to allergy vaccines bypassing allergen‐specific immunoglobulin E and T cell reactivity

“…So far, there are almost no studies in which objective provocation testing (e.g. quantitative skin testing, nasal provocation) was used to investigate whether the allergen-specific sensitivity changes in patients undergoing sublingual treatment [55][56][57][58][59].…”