Double-Blind Placebo-Controlled Study of Ibopamine and Diagoxin in Patients With Mild to Moderate Heart Failure: Results of the Dutch of the Ibopamine Multicenter Trial (DIMT)

Abstract

Ibopamine and digoxin both inhibit neurohumoral activation in patients with mild to moderate chronic heart failure. However, the clinical effects of these drugs are different and appear to be related to the degree of left ventricular dysfunction.

Inotropic agents for heart failure: what if digoxin increases mortality?

“…By contrast, the Dutch ibopamine multicentre trial suggested that digoxin exerted clinical benefits even in patients with moderate heart failure who were treated only with diuretics. 55 Two recent studies in patients with mild to moderate heart failure and sinus rhythm indicate that such patients also tend to deteriorate after abrupt withdrawal of digitalis.68 69 The RADIANCE study is particularly noteworthy in this respect, as all patients in this study, in contrast to previous investigations with digitalis, were taking ACE inhibitors69 (fig 6). Thus, when clinical efficacy is concerned, it makes sense to give digitalis to patients with comparatively severe heart failure and sinus rhythm despite the accepted standard treatment of diuretics and ACE inhibitors.…”

Randomised study of effect of ibopamine on survival in patients with advanced severe heart failure

“…5 Previous studies showed that in patients with heart failure, ibopamine reduced plasma concentrations of noradrenaline, renin activity, and aldosterone. [6][7][8] Clinical studies have reported that ibopamine improves symptoms and has an effect similar to captopril on exercise tolerance in patients with mild-tomoderate heart failure. 9,10 Ibopamine seemed to be a new class of drug that might make an important contribution to the management of patients with heart failure.…”

Role of heart rate in mechanisms of compensation and decompensation in patients with CHF and sinus rhythm or atrial fibrillation and methods for safe and effective control of the heart rhythm. Part 1. Sinus rhythm

“…Вторым объяснением положительных эффектов дигоксина при ХСН может служить его способность даже в небольших дозировках снижать активность САС [75,76] и даже РААС [77].…”