Double-blind placebo-controlled randomized clinical trial of ginger (<i>Zingiber officinale Rosc.</i>) addition in migraine acute treatment

Martins, Laís Bhering; Rodrigues, Ana Maria dos Santos; Rodrigues, Débora F.; Santos, Luana Caroline dos; Teixeira, Antônio Lúcio; Ferreira, Adaliene Versiani Matos

doi:10.1177/0333102418776016

Cited by 40 publications

(32 citation statements)

References 33 publications

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“…Migraines and headaches were examined to assess the pain-relieving attributes of ginger in three RCTs. Maghbooli et al and Martins et al compared the effects of sumatriptan and placebo, respectively, both showing there was a significant difference in symptom attenuation (p < 0.05) [23,66]. Patients with low back pain and chest pain caused by percutaneous transluminal coronary angioplasty were also selected to assess the analgesic effects of ginger, and both studies concluded that ginger was a useful option for pain relief.…”

Section: Analgesic Functionmentioning

confidence: 99%

Ginger on Human Health: A Comprehensive Systematic Review of 109 Randomized Controlled Trials

et al. 2020

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Clinical applications of ginger with an expectation of clinical benefits are receiving significant attention. This systematic review aims to provide a comprehensive discussion in terms of the clinical effects of ginger in all reported areas. Following the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guideline, randomized controlled trials on the effects of ginger were investigated. Accordingly, 109 eligible papers were fully extracted in terms of study design, population characteristics, evaluation systems, adverse effects, and main outcomes. The reporting quality of the included studies was assessed based on the Cochrane Collaboration’s tool for assessing the risk of bias in randomized trials and integrated together with studies that investigated the same subjects. The included studies that examined the improvement of nausea and vomiting in pregnancy, inflammation, metabolic syndromes, digestive function, and colorectal cancer’s markers were consistently supported, whereas other expected functions were relatively controversial. Nevertheless, only 43 clinical trials (39.4%) met the criterion of having a ‘high quality of evidence.’ In addition to the quality assessment result, small populations and unstandardized evaluation systems were the observed shortcomings in ginger clinical trials. Further studies with adequate designs are warranted to validate the reported clinical functions of ginger.

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Section: Analgesic Functionmentioning

confidence: 99%

Ginger on Human Health: A Comprehensive Systematic Review of 109 Randomized Controlled Trials

et al. 2020

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“…Previous studies have shown the efficacy of ginger, in extract or powder, in reducing and preventing pain associated with medical conditions (8–10,17). In this study, we showed that the use of ginger extract in the prophylactic treatment of migraine was not effective in decreasing the frequency of migraine attacks.…”

Section: Discussionmentioning

confidence: 99%

“…We and others showed that ginger is effective in decreasing the intensity of migraine pain when administered as an acute strategy (17,36). In a double-blind, randomized and controlled clinical trial, Maghbooli showed that the use of 250 mg of ginger powder during migraine attacks was as effective as 50 mg of sumatriptan in relieving pain intensity 2 h after ginger intake (36).…”

Section: Discussionmentioning

confidence: 99%

“…Recently, our group showed that the addition of ginger extract (400 mg) to ketoprofen in the treatment of acute migraine promotes a further reduction in pain and an improvement in functional status (17). The analgesic effect of ginger has been attributed to the capacity of its active components (gingerols and shogaols) to inhibit prostaglandin biosynthesis by decreasing the expression of cyclooxygenase-2 enzyme (COX-2) as non-steroidal anti-inflammatory drugs (18).…”

Section: Introductionmentioning

confidence: 99%

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Double-blind placebo-controlled randomized clinical trial of ginger (Zingiber officinale Rosc.) in the prophylactic treatment of migraine

et al. 2019

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Background Previous studies have shown an analgesic effect of ginger in the acute treatment of migraine, and there is anecdotal evidence of its efficacy in migraine prophylaxis. Objective This study aimed to evaluate the potential of ginger to prevent migraine attacks. Methods This double-blind, placebo-controlled randomized clinical trial took place at the Headache Clinic, Universidade Federal de Minas Gerais (Belo Horizonte, Minas Gerais, Brazil), involving 107 patients. Only subjects diagnosed with episodic migraine, aged between 18 and 60 years old, and who were not taking any prophylactic medication, were enrolled in the study. After one month of observation, subjects selected for the study were randomized 1:1 into placebo and treatment groups. Patients received capsules three times per day of 200 mg of dry extract of ginger (5% active ingredient) or placebo (cellulose) for three months. Visits were performed monthly and the patients were asked to fill in a migraine diary. The adherence to treatment was evaluated by counting capsules. Results The percentage of patients who responded to treatment (i.e. a reduction of 50% in the number of migraine attacks at the end of treatment) did not differ between the groups. There was a decrease in the number of days with severe pain, analgesic use for acute migraine and duration of migraine attacks in both groups, without significant difference between ginger and placebo groups. Conclusions Ginger provides no greater benefit in the prophylactic treatment of migraine when compared to placebo. This trial is registered at ClinicalTrials.gov (NCT02570633).

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“…68 In addition, ginger was shown in a randomized placebo-controlled trial to provide better acute symptom management in addition to typical nonsteroidal anti-inflammatory drug treatment in the emergency department setting. 69…”

Section: Lifestyle and Other Therapiesmentioning

confidence: 99%

Migraine Aura: Pathophysiology, Mimics, and Treatment Options

et al. 2019

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Recent insights into the clinical presentation and pathophysiology of migraine aura have paved the way for new treatments for this common but frequently debilitating condition. Marked efflux of cellular potassium and glutamate contributes to the cortical spreading depression that forms the electrophysiological basis of migraine aura phenomena. Secondary vascular perturbations also contribute to the various symptoms of a migraine attack. Calcitonin gene-related peptide (CGRP) plays a key role in many of these steps, and a growing class of CGRP-antagonists have emerged as a novel, efficacious preventative therapy. It is still not fully understood why a preponderance of migraine aura symptoms is visual, and this issue is an active area of research. In addition, the pathophysiological changes responsible for visual snow syndrome are under investigation. Before diagnosing a patient with migraine aura, it is important to consider the differential diagnosis of transient visual phenomena, with attention to clinical features that may suggest conditions such as retinal disorders, transient ischemic attack, or occipital epilepsy.

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Double-blind placebo-controlled randomized clinical trial of ginger (Zingiber officinale Rosc.) addition in migraine acute treatment

Cited by 40 publications

References 33 publications

Ginger on Human Health: A Comprehensive Systematic Review of 109 Randomized Controlled Trials

Ginger on Human Health: A Comprehensive Systematic Review of 109 Randomized Controlled Trials

Double-blind placebo-controlled randomized clinical trial of ginger (Zingiber officinale Rosc.) in the prophylactic treatment of migraine

Migraine Aura: Pathophysiology, Mimics, and Treatment Options

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