Double-blind, placebo-controlled, randomised study of single dose effects of ADAPT-232 on cognitive functions

Aslanyan, G.; Amroyan, É. A.; Gabrielyan, É. S.; Nylander, M.; Wikman, G.; Panossian, Alexander

doi:10.1016/j.phymed.2010.02.005

Cited by 51 publications

(47 citation statements)

References 12 publications

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“…Resveratrol, a SIRT1 activator, limits plaque formation in Alzheimer mutant mice (Solberg et al 2014). A combination of adaptogens, Eleutherococcus senticocus, Schisandra chinensis, and Rhodiola rosea, raises HSP levels (Panossian et al 2009) and improves memory and cognitive performance (Aslanyan et al 2010). Curcumin activates HSF1 (Teiten et al 2009) and augments memory function (Zhang et al 2015a).…”

Section: Hsf1 Inducers and Cognitive Preservationmentioning

confidence: 99%

The central role of heat shock factor 1 in synaptic fidelity and memory consolidation

Hooper

Durham

Török

et al. 2016

Cell Stress and Chaperones

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Networks of neuronal synapses are the fundamental basis for making and retaining memory. Reduced synapse number and quality correlates with loss of memory in dementia. Heat shock factor 1 (HSF1), the major transcription factor regulating expression of heat shock genes, plays a central role in proteostasis, in establishing and sustaining synaptic fidelity and function, and in memory consolidation. Support for this thesis is based on these observations: (1) heat shock induces improvements in synapse integrity and memory consolidation; (2) synaptic depolarization activates HSF1; (3) activation of HSF1 alone (independent of the canonical heat shock response) augments formation of essential synaptic elementsneuroligands, vesicle transport, synaptic scaffolding proteins, lipid rafts, synaptic spines, and axodendritic synapses; (4) HSF1 coalesces and activates memory receptors in the postsynaptic dendritic spine; (5) huntingtin or α-synuclein accumulation lowers HSF1 while HSF1 lowers huntingtin and α-synuclein aggregation-a potential vicious cycle; and (6) HSF1 agonists (including physical activity) can improve cognitive function in dementia models. Thus, via direct gene expression of synaptic elements, production of HSPs that assure high protein fidelity, and activation of other neuroprotective signaling pathways, HSF1 agonists could provide breakthrough therapy for dementia-associated disease.

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Section: Hsf1 Inducers and Cognitive Preservationmentioning

confidence: 99%

The central role of heat shock factor 1 in synaptic fidelity and memory consolidation

Hooper

Durham

Török

et al. 2016

Cell Stress and Chaperones

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“…They possess adaptogenic and stress-protective (neuro-cardio and hepato protective) and antioxidant effects, as well as stimulating effects on the central nervous system, including on cognitive functions such as attention, memory and learning; anti-fatigue effects; antidepressive and anxiolytic effects; endocrine activity normalizing; and life-span increasing effects (Aslanyan et al, 2010; Sarris et al, 2011; Panossian et al, 2013). The main active compounds are reputedly phenylpropanoids (rosavin, rosarin, rosin) and phenylethanoids (salidroside and tyrosol).…”

Section: Introductionmentioning

confidence: 99%

From Traditional Resource to Global Commodities:—A Comparison of Rhodiola Species Using NMR Spectroscopy—Metabolomics and HPTLC

et al. 2016

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The fast developing international trade of products based on traditional knowledge and their value chains has become an important aspect of the ethnopharmacological debate. The structure and diversity of value chains and their impact on the phytochemical composition of herbal medicinal products, as well as the underlying government policies and regulations, have been overlooked in the debate about quality problems in transnational trade. Rhodiola species, including Rhodiola rosea L. and Rhodiola crenulata (Hook. f. & Thomson) H. Ohba, are used as traditional herbal medicines. Faced with resource depletion and environment destruction, R. rosea and R. crenulata are becoming endangered, making them more economically valuable to collectors and middlemen, and also increasing the risk of adulteration and low quality. Rhodiola products have been subject to adulteration and we recently assessed 39 commercial products for their composition and quality. However, the range of Rhodiola species potentially implicated has not been assessed. Also, the ability of selected analytical techniques in differentiating these species is not known yet. Using a strategy previously developed by our group, we compare the phytochemical differences among Rhodiola raw materials available on the market to provide a practical method for the identification of different Rhodiola species from Europe and Asia and the detection of potential adulterants. Nuclear magnetic resonance spectroscopy coupled with multivariate analysis software and high performance thin layer chromatography techniques were used to analyse the samples. Rosavin and rosarin were mainly present in R. rosea but also in Rosea sachalinensis Borris. 30% of the Rhodiola samples purchased from the Chinese market were adulterated by other Rhodiola spp. The utilization of a combined platform based on 1H-NMR and HPTLC methods resulted in an integrated analysis of different Rhodiola species. We identified adulteration at the earliest stage of the value chains, i.e., during collection as a key problem involving several species. This project also highlights the need to further study the links between producers and consumers in national and trans-national trade.

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“…Adverse events (AEs) due to R. rosea intake are rare and mild (sleepiness and cold extremities) (Aslanyan et al 2010;Hung et al 2011). R. rosea has the potential to enhance the action of stimulating medications, therefore, should not be used concomitantly with such medications.…”

Section: Clinical Trialsmentioning

confidence: 99%

Rhodiola rosea L.: from golden root to green cell factories

et al. 2016

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Double-blind, placebo-controlled, randomised study of single dose effects of ADAPT-232 on cognitive functions

Cited by 51 publications

References 12 publications

The central role of heat shock factor 1 in synaptic fidelity and memory consolidation

The central role of heat shock factor 1 in synaptic fidelity and memory consolidation

From Traditional Resource to Global Commodities:—A Comparison of Rhodiola Species Using NMR Spectroscopy—Metabolomics and HPTLC

Rhodiola rosea L.: from golden root to green cell factories

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