Double-blind, placebo-controlled pharmacodynamic studies with a nutraceutical and a pharmaceutical dose of ademetionine (SAMe) in elderly subjects, utilizing EEG mapping and psychometry

Arnold, Oliver; Saletu, B.; Anderer, P.; Assandri, Alessandro; Padova, C. Di; Corrado, Mario E.; Saletu-Zyhlarz, Gerda

doi:10.1016/j.euroneuro.2005.01.004

Cited by 6 publications

(4 citation statements)

References 39 publications

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“…Arnold et al [121] demonstrated that S-adenosyl-l-methionine produced an increase in total EEG power, a decrease in relative and absolute power in the slow alpha and delta/theta frequencies, an increase in relative and absolute power in the beta and alpha-2 frequencies, and an acceleration of the centroids of the alpha and total power spectrum in elderly normal volunteers. Bruder et al [122] demonstrated that depressed patients whom were considered responders (“much or very much improved” as measured by the Clinical Global Impression Improvement scale) to fluoxetine produced a greater alpha response over the right occipital region compared to the left region.…”

Section: Prominent Drug Classes In the Realm Of Eeg Pharmacodynamimentioning

confidence: 99%

Electroencephalogram-based pharmacodynamic measures: a review

Bewernitz

Derendorf

2012

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Pharmacokinetics and pharmacodynamics can provide a useful modeling framework for predicting drug activity and can serve as a basis for dose optimization. Determining a suitable biomarker or surrogate measure of drug effect for pharmacodynamic models can be challenging. The electroencephalograph is a widely-available and non-invasive tool for recording brain-wave activity simultaneously from multiple brain regions. Certain drug classes (such as drugs that act on the central nervous system) also generate a reproducible electroencephalogram (EEG) effect. Characterization of such a drug-induced EEG effect can produce pharmacokinetic/pharmacodynamic models useful for titrating drug levels and expediting development of chemically-similar drug analogs. This paper reviews the relevant concepts involved in pharmacokinetic/pharmacodynamic modeling using EEG-based pharmacodynamic measures. In addition, examples of such models for various drugs are organized by drug activity as well as chemical structure and presented.

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Section: Prominent Drug Classes In the Realm Of Eeg Pharmacodynamimentioning

confidence: 99%

Electroencephalogram-based pharmacodynamic measures: a review

Bewernitz

Derendorf

2012

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“…Methionine is another essential amino acid crucial to mental health. The methioninederivative S-adenosyl methionine, cofactor in the single carbon cycle is involved in the synthesis of serotonin, noradrenalin and dopamine as well as in providing methyl donors for DNA-and histone methylation [113]. Clinical data demonstrated the efficacy of adjunctive S-adenosyl methionine use to improve antidepressant response [73,114,115], even in case of selective serotonin reuptake inhibitor (SSRI)-treatment resistant patients [116].…”

Section: Nutritionmentioning

confidence: 99%

BDNF as a Mediator of Antidepressant Response: Recent Advances and Lifestyle Interactions

Cubillos

Engmann

Brancato

2022

IJMS

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Conventional antidepressants are widely employed in several psychiatric and neurologic disorders, yet the mechanisms underlying their delayed and partial therapeutic effects are only gradually being understood. This narrative review provides an up-to-date overview of the interplay between antidepressant treatment and Brain-Derived Neurotrophic Factor (BDNF) signaling. In addition, the impact of nutritional, environmental and physiological factors on BDNF and the antidepressant response is outlined. This review underlines the necessity to include information on lifestyle choices in testing and developing antidepressant treatments in the future.

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“…However, SAMe serves as a methyl-donating cofactor in the rate-limiting step in the synthesis of serotonin, dopamine, and norepinephrine, and it is associated with elevated levels of these neurotransmitters [31]. In addition, neuroimaging studies reveal that the effects of SAMe on the brain are similar to those of conventional antidepressants, including TCAs, SSRIs, and SNRIs [32] [33]. SAMe is available in several salt forms with varying bioavailability and is often marketed as a single-agent product [30].…”

Section: S-adenosylmethionine (Same)mentioning

confidence: 99%

Anxiety-Inducing Dietary Supplements: A Review of Herbs and Other Supplements with Anxiogenic Properties

McCarthy¹,

Candelario²,

Liu³

2014

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Anxiety disorders comprise the most common group of mental disorders to affect the general population in the United States. These disorders are heterogeneous in nature, highly comorbid with one another, and pose a degree of difficulty regarding diagnosis and management. The exact etiology and pathophysiology of anxiety remains to be elucidated; however, it is likely that it is multifactorial, and all potential causes of anxiety must be investigated, including substance-induced anxiety. Among substances that may induce anxiety are dietary supplements. As utilization of these products appears to be high in the US population, it is important to identify which of available supplements may cause anxiety. Objective: To review the scientific literature to identify dietary supplements associated with induction of anxiety and related symptoms. Methods: A search of Natural Medicines Comprehensive Database, MedlinePlus Herbs and Supplements, and Natural Standard was performed to identify dietary supplements with anxiogenic properties. Dietary supplements were included based on product availability, utilization trends, and if there was sufficient evidence that the substance could elicit anxiety via direct pharmacologic effects. Agents were excluded from the review if anxiety was solely due to withdrawal from the substance or only occurred in the setting of intoxication. A search of MEDLINE and PUBMED was performed to identify relevant peer reviewed publications concerning induction of anxiety and/or its associated symptoms by those dietary supplements chosen for review. Conclusions: Dietary supplements can contribute to and cause anxiety and its related symptoms via overstimulation of the Central Nervous System. Healthcare professionals should screen all patients presenting with symptoms consistent with anxiety for recent or current use of all products capable of inducing anxiety, including dietary supplements.

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Double-blind, placebo-controlled pharmacodynamic studies with a nutraceutical and a pharmaceutical dose of ademetionine (SAMe) in elderly subjects, utilizing EEG mapping and psychometry

Cited by 6 publications

References 39 publications

Electroencephalogram-based pharmacodynamic measures: a review

Electroencephalogram-based pharmacodynamic measures: a review

BDNF as a Mediator of Antidepressant Response: Recent Advances and Lifestyle Interactions

Anxiety-Inducing Dietary Supplements: A Review of Herbs and Other Supplements with Anxiogenic Properties

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