Double-Blind Crossover Trial of Naproxen and Placebo in Patients with Rheumatoid Arthritis

Rf, Willkens

doi:10.3109/03009747309097112

Cited by 13 publications

(3 citation statements)

References 3 publications

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“…Naproxen (+ )-6-methoxy-a-methyl-2-naphthaleneacetic acid, Naprosyn) is a nonsteroidal anti-inflammatory drug which has been shown to be effective in rheumatoid arthritis!' 6, 19 and as an analgesic. 9 .…”

mentioning

confidence: 99%

Pharmacokinetics of naproxen overdoses

Runkel¹,

Chaplin²,

Sevelius³

et al. 1976

Clin Pharma and Therapeutics

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In earlier safety studies, naproxen, 600 mg three times daily, was administered to healthy subject without significant adverse effects. Another study demonstrated that single doses of 500 to 900 mg resulted in accelerated renal clearance and a nonlinear naproxen plasma level response after the higher doses. Our report describes the pharmacokinetics of naproxen when administered in single doses of 1, 2, 3, or 4 gm (up to eight times the clinically effective dose in rheumatoid arthritis) to healthy subjects. An increase in urinary excretion rate and continuation of the previously documented nonlinear plasma level response were observed. There were no signs that capacity to conjugate or to excrete the drug was exceeded. There were no adverse effects.

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mentioning

confidence: 99%

Pharmacokinetics of naproxen overdoses

Runkel¹,

Chaplin²,

Sevelius³

et al. 1976

Clin Pharma and Therapeutics

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“…Naproxen (Naprosyn, Naxen) , a nonsteroidal anti-inflammatory drug developed by Syntex Research, 5 has been shown to be an effective anti-inflammatory agent in rheumatoid arthritis, 9,18 as well as an analgesic. 12 ,15 In these trials naproxen has been administered alone or superimposed on maintenance therapy with gold, systemic corticosteroids, or antimalarial drugs.…”

mentioning

confidence: 99%

Naproxen‐aspirin interactions in man

Segre¹,

Chaplin²,

Forchielli³

et al. 1974

Clin Pharma and Therapeutics

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Pharmacokinetic interactions between aspirin and other nonsteroidal anti‐inflammatory drugs, including naproxen, have been demonstrated in experimental animals. This study shows that simultaneous oral administration of aspirin and naproxen in man results in a small but statistically significant lowering of plasma levels of naproxen. This effect is not mediated by competition for drug absorption but is associated with enhanced renal clearance of naproxen or its metabolites. Salicylates displace naproxen from binding sites on plasma proteins, a phenomenon that may be responsible for the accelerated clearance. The clinical significance, if any, Of these findings is not yet established, but the relatively small magnitude of the effects noted suggests that the likelihood of a meaningful interaction is small.

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“…A number of clinical therapeutic trials have been reported in which naproxen has been compared with placebo and with other antirheumatic drugs, such as aspirin, indomethacin, ibuprofen, fenoprofen.6~"~18-20,22,23~25.26, 41 These studies clearly indicate that naproxen has analgesic effects approximately equivalent to aspirin, but there was no definite evidence that the drug had an anti-inflammatory effect.20. 25 The purpose of the present study was three-fold.…”

Section: Introductionmentioning

confidence: 96%

Clinical evaluation of two daily doses of naproxen and indomethacin: result of a double-blind crossover trial

Hernández¹,

Macleod

Grennan

et al. 1975

Current Medical Research and Opinion

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A double-blind crossover clinical trial is reported on the effects of naproxen in two doses, 500 mg. and 750 mg. daily, and 100 mg. indomethacin daily in 23 patients with classical rheumatoid arthritis, each drug being given for 1 week. The results show that there was little to choose between the drugs and that there was clinical equivalence between the two doses of naproxen. Radioactive pertechnetate (99mTc) joint uptakes were depressed by both naproxen and indomethacin, indicating anti-inflammatory effect.

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Double-Blind Crossover Trial of Naproxen and Placebo in Patients with Rheumatoid Arthritis

Cited by 13 publications

References 3 publications

Pharmacokinetics of naproxen overdoses

Pharmacokinetics of naproxen overdoses

Naproxen‐aspirin interactions in man

Clinical evaluation of two daily doses of naproxen and indomethacin: result of a double-blind crossover trial

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