Double-blind Cross-over Trial Comparing Intranasal Beclomethasone Dipropionate and Placebo in Perennial Rhinitis

Gibson, Gretchen; Maberly, D. J.; Lal, Shankar; Ali, Muhammad Mustafa; Butler, A. G.

doi:10.1136/bmj.4.5943.503

Cited by 59 publications

(19 citation statements)

References 9 publications

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“…A doseresponse investigation has indicated, however, that the daily starting dose should be 400 ,ug in all hay fever patients (Andersen, Halberg, and Mygind, 1975). Gibson et al (1974) have shown that intranasal beclomethasone dipropionate 200 ,ug daily over a 3-week period improved the symptoms of adults suffering from perennial rhinitis without any evidence of adrenal suppression. Godfrey and Konig (1974) showed that inhaled beclomethasone dipropionate at doses varying from 100 to 600 ,ug/ day during their trials and for a maximum of 8 months' follow-up showed no evidence of suppressing either adrenal function or growth.…”

Section: Discussionmentioning

confidence: 99%

“…However, since corticosteroids so administeredl affect adrenal function their use in children for such a minor disorder as hay fever is usually unjustifiable. Recently it has been shown that the local application of beclomethasone dipropionate is an efficient treatment of nasal symptoms in adults with hay fever (Mygind, 1973), perennial rhinitis (Hansen and Mygind, 1974;Gibson et al, 1974), and nasal polyps . As the daily dose used in these trials has been shown not to suppress adrenal function we felt justified in using the drug intranasally in children suffering from hay fever Patients and methods Eighteen children with a history of hay fever symptoms for at least two seasons entered the trial.…”

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confidence: 99%

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Beclomethasone dipropionate aerosol in treatment of hay fever in children.

Prahl¹,

Wilken-Jensen²,

Mygind³

1975

Archives of Disease in Childhood

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Beclomethasone dipropionate aerosol in treatment of hay fever in children.

Prahl¹,

Wilken-Jensen²,

Mygind³

1975

Archives of Disease in Childhood

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“…Most of the patients (80%) have now had summers free from hay fever for four successive years. (Gibson et at., 1974;Hansen & Mygind, 1974;Smith et al, 1975) and for nasal polypi . All the results have been very similar to ours, but we can now confirm by long-term observation in large numbers of patients that no side-effects have been found even when treatment has been given daily for up to 5 yr.…”

Section: Seasonal Allergic Rhinitismentioning

confidence: 99%

Beclomethasone dipropionate aerosol in treatment of perennial and seasonal rhinitis: a review of five years' experience.

Brown¹,

Storey²,

Jackson³

1977

Brit J Clinical Pharma

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1. Five years' experience in the use of beclomethasone dipropionate aerosol (BDA) in the treatment of 315 patients with upper respiratory tract allergy is reviewed. 2. A total of 223 patients with perennial rhinitis was treated. In 23, where the nasal allergy had recurred after oral corticosteroid therapy for asthma was withdrawn, BDA was effective in 69% of cases. A similar success rate (68%) was recorded in 169 patients suffering from perennial allergic rhinitis alone, but a satisfactory response was observed in only 45% of 31 patients with nasal polypi. 3. In 92 patients with seasonal allergic rhinitis freedom from symptoms was achieved in 80%. 4. A total of approximately 534 patient‐years of treatment has been recorded without any evidence of side‐effects either clinically or on nasal biopsy.

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“…At the same time, always in the morning (7)(8)(9) MATERIAL AND METHODS ''"•'• ^ !7"".'^'"P'". At the same time, always in the morning (7)(8)(9) MATERIAL AND METHODS ''"•'• ^ !7"".'^'"P'".…”

mentioning

confidence: 99%

Reduction of Metacholine‐Induced Nasal Secretion by Treatment with a New Topical Steroid in Perennial Non‐Allergic Rhinitis

Malm

Lamm³

et al. 1981

Allergy

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The value of three objective tests of the nasal mucosa in 22 patients with perennial non-allergic rhinitis treated with a topical corticosteroid has been investigated. Placebo and three different dosages of a new steroid, budesonide, were administered intranasally using a double-blind, cross-over technique. Nasal airway resistance was not reduced by the steroid treatment as compared with the placebo treatment. Eosinophilia in nasal smears was reduced by budesonide. However, the value of this test was decreased by the fact that eosinophilia was found in less than 50% of the patients at the beginning of the trial. Metacholine-induced nasal secretion was significantly reduced by the budesonide treatment. Symptom scores for nasal obstruction, secretion and sneezing attacks were also significantly reduced by the steroid.

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Double-blind Cross-over Trial Comparing Intranasal Beclomethasone Dipropionate and Placebo in Perennial Rhinitis

Cited by 59 publications

References 9 publications

Beclomethasone dipropionate aerosol in treatment of hay fever in children.

Beclomethasone dipropionate aerosol in treatment of hay fever in children.

Beclomethasone dipropionate aerosol in treatment of perennial and seasonal rhinitis: a review of five years' experience.

Reduction of Metacholine‐Induced Nasal Secretion by Treatment with a New Topical Steroid in Perennial Non‐Allergic Rhinitis

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