Double-Blind Controlled Study on the Effects of Dietary Diacylglycerol on Postprandial Serum and Chylomicron Triacylglycerol Responses in Healthy Humans

Taguchi, Hiroyuki; Watanabe, Hiroyuki; Onizawa, Kouji; Nagao, Tomonori; Gotoh, Naohiro; Yasukawa, Takuji; Tsushima, Rikio; Shimasaki, Hiroyuki; Itakura, Hiroshige

doi:10.1080/07315724.2000.10718079

Cited by 183 publications

(125 citation statements)

References 40 publications

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“…2. As reported in previous studies in rodents and humans (7)(8)(9)(10)(11)(12)(13)(14)(15)(16), in the present study, there was a significant reduction in the postprandial total serum TG level after DAG administration compared with that after TAG administration (Fig. 2, top panel, p ϭ 0.028 (time ϫ oil) by repeated measures two-way ANOVA, p Ͻ 0.05 at the 1 and 2-h time-points by Student's t test).…”

Section: Changes In Postprandial Total Serum Tg and Cholesterol Levelssupporting

confidence: 70%

Size-Based Distributions of Postprandial Lipoproteins in Lymph and Serum after Oral Administration of Triacylglycerol and Diacylglycerol Oils in Rats

Saito

Nakagiri

Watanabe

et al. 2008

J Nutr Sci Vitaminol

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Summary Several studies in humans and rodents suggest that postprandial serum triglyceride (TG) levels are decreased by a single oral administration of diacylglycerol (DAG) oil compared with administration of control triacylglycerol (TAG) oil. To gain further insight into the mechanisms underlying the metabolic properties of DAG in a postprandial state, we analyzed the size-based distributions of postprandial lipoproteins in the lymph and serum using gel filtration-based high-performance liquid chromatography. In thoracic duct lymph pooled for 3 h after oral administration of TAG or DAG, the size-based distributions of postprandial lymphatic lipoprotein-TG and -cholesterol levels did not differ significantly, suggesting that DAG did not affect the size of lipoprotein particles secreted from the small intestine. Serum lipoprotein-TG (60%) and -cholesterol levels (90%), however, were significantly different among fractions with a diameter of greater than 80 nm 1 to 2 h after the administration of DAG compared to TAG. In addition, there was a considerable, but nonsignificant, reduction in lipoprotein-TG levels (~ 40%) in fractions with a diameter of 80 to 30 nm, suggesting that DAG-derived chylomicrons as well as DAG-derived chylomicron remnants were catabolized rapidly. In conclusion, dietary DAG reduced the amount of large-size lipoproteins in the serum, but did not affect the size distribution of lipoproteins produced in the small intestine. Thus, compared with TAG, dietary DAG may reduce the postprandial serum total TG levels.

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Section: Changes In Postprandial Total Serum Tg and Cholesterol Levelssupporting

confidence: 70%

Size-Based Distributions of Postprandial Lipoproteins in Lymph and Serum after Oral Administration of Triacylglycerol and Diacylglycerol Oils in Rats

Saito

Nakagiri

Watanabe

et al. 2008

J Nutr Sci Vitaminol

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“…Recent studies have suggested that DG consumed in larger amounts may have metabolic characteristics distinct from TG, which may produce bene®cial effects with regard to prevention and management of obesity. Experimental studies in animals and humans have shown that DG reduces postprandial triglyceridemia compared with TG control (Murata et al, 1994;Taguchi et al, 2000). In controlled feeding studies, DG reduced body weight and abdominal fat stores in Japanese men .…”

Section: Introductionmentioning

confidence: 99%

Solubilization of phytosterols in diacylglycerol versus triacylglycerol improves the serum cholesterol-lowering effect

et al. 2001

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Objective: This study was performed to investigate the difference in the serum-cholesterol-and triglyceridelowering activities between phytosterols dissolved in diacylglycerol (PSaDG) and dispersed in triacylglycerol (PSaTG). The effects of the solvent on the concentrations of serum b-sitosterol and campesterol were examined. Design: The study had a randomised crossover design. Subjects: Twelve healthy normocholesterolemic or moderately hypercholesterolemic men aged 29 ± 50 y participated in this study. Interventions: For 2 weeks before the test period (designated as the control period), all subjects consumed control mayonnaise (PS free) daily with supper and were randomly assigned to two groups for the 2 week test period; one group was given mayonnaise containing PS (500 mgaday) dissolved in DG (10 gaday), and the other mayonnaise containing PS (500 mgaday) dispersed in TG (10 gaday). After a wash out period consuming control PS-free mayonnaise for 4 weeks, the groups were reversed for 2 weeks. Results: PSaTG feeding had no effect on the serum cholesterol level. In contrast, PSaDG feeding signi®cantly reduced the total and LDL cholesterol levels from the initial value of 5.57 to 5.31 mmolal (4.7%; P`0.05) and from 3.69 to 3.39 mmolal (7.6%; P`0.05), respectively. Moreover, the degree of total cholesterol reduction induced by PSaDG feeding in the test period was signi®cantly greater than that induced by PSaTG feeding (P`0.05). In addition, the serum b-sitosterol and campesterol concentrations did not change during the PSaTG or PSaDG feeding periods. Conclusions: Dissolution of PS in DG had a better serum cholesterol lowering effect than dissolution in TG.

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“…However, we did not detect obvious additive or synergistic significances. The physiological functions of DAG appear to be defined by dietary conditions, as indicated by Taguchi et al 12) In our study, the expected physiological effects of the combined DAG and SPI diets were small in the lipid profiles of the rats. Therefore, it might be necessary to take dietary conditions into consideration in order to achive beneficial functions of food components.…”

Section: Discussionmentioning

confidence: 67%

“…12,14,24) Since the physiological benefits and the mechanisms of SPI and DAG have been established, 11,28) the physiological impacts of simultaneous intake of foods and food components of similar function are expected Values are means AE SEM for five rats. When there was a significant interaction between dietary oil and protein, the significance of differences among groups was analyzed by Fisher's PLSD test.…”

Section: Discussionmentioning

confidence: 99%

“…10) On the other hand, DAG, which consists mainly of sn-1, 3 species, has been shown to suppress body fat accumulation in mice much more than dietary TG with a similar fatty acid composition, 11) and also to prevent increases in postprandial serum TG concentrations in healthy humans. 12) In addition, long-term intake of DAG also lowered the serum TG concentration in type II diabetic patients with hypertriglyceridemia. 13) These physiological effects of DAG depend on different metabolic functioning due to structures differing from TG.…”

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confidence: 99%

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Effects of Simultaneous Intake of Soybean Protein and Diacylglycerol on Lipid Profiles and Body Fat Accumulation in Rats

Nagata¹,

Yamada²

2009

Bioscience, Biotechnology, and Biochemistry

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Double-Blind Controlled Study on the Effects of Dietary Diacylglycerol on Postprandial Serum and Chylomicron Triacylglycerol Responses in Healthy Humans

Abstract: In the usual range of fat intake (10-44 g), postprandial response after ingestion of DG emulsion was significantly less than that after ingestion of TG emulsion in healthy human subjects.

Cited by 183 publications

References 40 publications

Size-Based Distributions of Postprandial Lipoproteins in Lymph and Serum after Oral Administration of Triacylglycerol and Diacylglycerol Oils in Rats

Size-Based Distributions of Postprandial Lipoproteins in Lymph and Serum after Oral Administration of Triacylglycerol and Diacylglycerol Oils in Rats

Solubilization of phytosterols in diacylglycerol versus triacylglycerol improves the serum cholesterol-lowering effect

Effects of Simultaneous Intake of Soybean Protein and Diacylglycerol on Lipid Profiles and Body Fat Accumulation in Rats

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