Double‐Blind Comparison of Triamterene Plus Hydrochlorothiazide and Spironolactone Plus Hydrochlorothiazide in the Treatment of Hypertension

Cocke, Thomas B.; Fisch, Solomon; Gilmore, Hugh R.; Okun, Ronald; Tamagna, Irene G.; Wipplinger, Karl

doi:10.1002/j.1552-4604.1977.tb04613.x

Cited by 6 publications

(1 citation statement)

References 2 publications

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“…TA has been utilized either alone [18,19] or in combi nation with potassium-wasting diuretics, such as thia zides [4,[20][21][22] or furosemide [23,24], to both increase natriuresis as well as to minimize the ensuing kaliuresis. TA inhibits passive sodium transport from the luminal side of transporting epithelia [25][26][27], resulting in im paired movement of potassium from cell to lumen, since the latter is functionally coupled to sodium movement.…”

Section: Pharmacodynamicsmentioning

confidence: 99%

Triamterene and the Kidney

Sica¹,

Gehr²

1989

Nephron

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Triamterene (TA) is a mild ‘potassium-sparing’ diuretic usually employed in combination with other more potent diuretics in the treatment of hypertension. TA pharmacokinetics and pharmacodynamics in normal volunteers, elderly subjects and in patients with renal and hepatic dysfunction are reviewed. A variety of adverse renal effects, such as abnormalities in urinary sediment, nephrolithiasis, interstitial nephritis and acute renal failure, has been reported to occur and is also reviewed. Of particular concern with the increased availability of ‘over-the-counter’ nonsteroidal anti-inflammatory medications (NSAID) is the adverse interaction between TA and NSAID which may culminate in acute renal failure. Although a rare occurrence, the clinician should be aware of potential adverse reactions associated with the use of TA.

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