Double-blind comparison of ropivacaine 7.5 mg ml–1 with bupivacaine 5 mg ml–1 for sciatic nerve block

Connolly, Cara; Coventry, D.M.; Wildsmith, J.A.W.

doi:10.1093/bja/86.5.674

Cited by 16 publications

(14 citation statements)

References 16 publications

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“…Sensory and motor onset times in our study correlated with studies by Conolly et al, 4 Beaulieu et al, 16 Sinari D et al 17 and Cuvillion et al 12 where they did not observe statistically significant difference between the two drugs in terms of onset times.…”

Section: Variablessupporting

confidence: 91%

“…4 Sciatic nerve block when combined with femoral nerve block provides effective anaesthesia of lower limb. It may also be used more readily in the presence of minor degree of coagulopathy or after head injury where central neuraxial block is relatively contraindicated.…”

mentioning

confidence: 99%

“…It may also be used more readily in the presence of minor degree of coagulopathy or after head injury where central neuraxial block is relatively contraindicated. 4 Long acting Local Anaesthetics (LA) are commonly used for sciatic nerve block, as they provide prolonged postoperative analgesia and Bupivacaine is the most commonly used LA for this purpose. Ropivacaine, a newer long acting amide LA has similar clinical characteristics as that of Bupivacaine and is produced as pure S-enantiomer, hence less potential for cardiotoxicity.…”

mentioning

confidence: 99%

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A Prospective, Randomised, Double-Blind Comparative Clinical Study of 0.5% Bupivacaine and 0.75% Ropivacaine for Sciatic Nerve Block in Patients Undergoing Elective Below Knee Surgeries

Hegde¹,

Manjunath²

2016

jemds

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BACKGROUNDSciatic nerve block is a useful technique for unilateral lower limb surgeries. Bupivacaine is the most commonly used long acting amide local anaesthetic agent for peripheral nerve blockade. Ropivacaine, a newly introduced amide local anaesthetic is similar to Bupivacaine in structure, less potent than bupivacaine and lacks cardiotoxic potential of Bupivacaine. Hence, this study is taken up to compare the block characteristics of equipotent doses of Bupivacaine and Ropivacaine.

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Section: Variablessupporting

confidence: 91%

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confidence: 99%

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confidence: 99%

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A Prospective, Randomised, Double-Blind Comparative Clinical Study of 0.5% Bupivacaine and 0.75% Ropivacaine for Sciatic Nerve Block in Patients Undergoing Elective Below Knee Surgeries

Hegde¹,

Manjunath²

2016

jemds

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“…However, the optimum dosage regimen for ropivacaine in paravertebral lumbar blockade has not yet been determined. We used a higher dose of ropivacaine as it was reported previously that the relative analgesic potency ratio was 0.65 (0.56-0.76) for ropivacaine and bupivacaine (7.5 mg ropivacaine and 5.0 mg bupivacaine in a 10-ml volume, respectively) [9,21] .…”

Section: Discussionmentioning

confidence: 99%

Lumbar Plexus Blockade with Ropivacaine for Postoperative Pain Management in Elderly Patients Undergoing Urologic Surgeries

Akın¹,

Aribogan

Turunç³

et al. 2005

Urol Int

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Background/Aims: We evaluated the effectiveness and safety of lumbar plexus blockade with ropivacaine for postoperative pain relief in elderly patients undergoing flank incision for urological surgery. Methods: 60 urological patients (>65 years old) were chosen randomly for paravertebral lumbar blockade. Postoperatively ropivacaine was used in group I (n = 30) and bupivacaine was administered in group II (n = 30) for lumbar plexus blockade. Heart rates, systolic and diastolic blood pressures, peripheral oxygen saturations, analgesia levels with visual analogue scales (VAS) were measured postoperatively at 5 and 30 min and 1, 3, 6, 8,and 12 h. Patient satisfaction scores and complications were recorded. Results: The hemodynamic parameters of the groups were in the normal ranges (p > 0.05). VAS were significantly decreased at 60 min in both groups (p < 0.05) and no important increase was observed during the first 8 h (p > 0.05). After the 8-hour measurement, analgesic was given to 7 patients in group I and 6 patients in group II (p < 0.05). There were no complications (p > 0.05). Patient satisfaction scores were found to be higher for all patients (p > 0.05). Conclusion: In elderly patients, lumbar plexus blockade with ropivacaine can be a simple, safe and effective analgesic technique especially in the early postoperative period after urologic surgeries with flank incision.

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“…The duration of analgesia after peripheral nerve blockade with bupivacaine is the same as [5] or longer than [6] the analgesic duration provided by ropivacaine. Bupivacaine is less expensive than ropivacaine or levobupivacaine.…”

Section: Introductionmentioning

confidence: 97%

Similar Analgesic Effect After Popliteal Fossa Nerve Blockade with 0.375% and 0.75% Bupivacaine

et al. 2007

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This study tested the hypothesis that increasing the concentration of bupivacaine from 0.375 to 0.75% would increase the duration of postoperative analgesia by 3 h. Seventy patients scheduled for hospital admission after foot or ankle surgery gave consent to enter this prospective randomized trial. Patients were randomly assigned to receive a popliteal fossa block (posterior approach) using 30 cc of either 0.375% or 0.75% bupivacaine, with epinephrine. Patients also received a neuraxial anesthetic and postoperative intravenous patient-controlled analgesia. Patient characteristics, duration of analgesia, pain scores, use of analgesic medications, and side effects of analgesic therapy were determined. Duration of analgesia was similar with both concentrations of bupivacaine (0.375% 14T8 h, 0.75% 13T6 h; meanTSD). Pain scores were the same for both groups on the first postoperative day (3 of 10 at rest, 5 with therapy). Analgesic use and side effects attributable to pain management did not differ between groups. In conclusion, postoperative analgesia was not affected by the concentration of bupivacaine used for the nerve block. There was no benefit to increasing the concentration of bupivacaine above 0.375% for single-injection popliteal fossa nerve blockade when performed for postoperative analgesia.

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Double-blind comparison of ropivacaine 7.5 mg ml–1 with bupivacaine 5 mg ml–1 for sciatic nerve block

Cited by 16 publications

References 16 publications

A Prospective, Randomised, Double-Blind Comparative Clinical Study of 0.5% Bupivacaine and 0.75% Ropivacaine for Sciatic Nerve Block in Patients Undergoing Elective Below Knee Surgeries

A Prospective, Randomised, Double-Blind Comparative Clinical Study of 0.5% Bupivacaine and 0.75% Ropivacaine for Sciatic Nerve Block in Patients Undergoing Elective Below Knee Surgeries

Lumbar Plexus Blockade with Ropivacaine for Postoperative Pain Management in Elderly Patients Undergoing Urologic Surgeries

Similar Analgesic Effect After Popliteal Fossa Nerve Blockade with 0.375% and 0.75% Bupivacaine

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