Double-Blind Comparison of Ibuprofen and Phenylbutazone in the Short-Term Treatment of Rheumatoid Arthritis

Pavelka, Karel; Susta, A; Vojtísĕk, O; Brémová, A; Kanková, D; Hándlová, D; Malecek, J

doi:10.1093/rheumatology/12.2.68

Cited by 7 publications

(2 citation statements)

References 5 publications

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“…During the short‐term period of drug exposure, we did not detect any differences in the tolerance and toxicity of the two drugs. Pavelka et al (7), in their study on rheumatoid arthritis, found that phenylbutazone‐related side effects occurred with twice the frequency of those associated with ibuprofen. These authors reported their data in a manner which makes it difficult to compare them with those obtained in our trial.…”

Section: Discussionmentioning

confidence: 99%

“…Several investigators regard the good tolerance of ibuprofen as an asset. Pavelka et al (7), in a double‐blind crossover study, compared the effects of ibuprofen (1200 mg daily) and phenylbutazone (600 mg daily) in 108 patients with rheumatoid arthritis during a four‐week trial. Half of the patients were treated with one drug or the other for the entire study; the other half “crossed over” to the second form of treatment after fourteen days.…”

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confidence: 99%

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Ibuprofen versus Buffered Phenylbutazone in the Treatment of Osteoarthritis: Double‐Blind Trial

Moxley

Royer

Hearron

et al. 1975

J American Geriatrics Society

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In a double-blind multiclinic trial, a new nonsteroidal anti-inflammatory agent (ibuprofen) was compared with an established therapeutic agent (phenylbutazone-alka) for the treatment of osteoarthritis. Of the 159 patients from the 17 contributing clinics, 144 completed the four weeks of therapy. More than 60 per cent of them reported improvement in exercise-related pain by week 4, and there was no significant difference between treatment groups. The patients' and the physicians' evaluations of the total state of disease, as well as range-of-motion and functional tests, demonstrated similar degrees of improvement in both treatment groups. The incidence of side effects was within acceptable limits, and the frequency distribution was similar in both groups. Of the 70 reported side effects, 29 were considered by the investigator (blind trial) to be drug-related-11 in association with ibuprofen and 18 with phenylbutazone-alka. Hematologic and blood chemical studies, as well as urine and stool examinations, yielded normal results with the exception of a reduced mean value for serum uric acid and a slightly elevated mean value for SGPT in the phenylbutazone-alka group.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Ibuprofen versus Buffered Phenylbutazone in the Treatment of Osteoarthritis: Double‐Blind Trial

Moxley

Royer

Hearron

et al. 1975

J American Geriatrics Society

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Pharmacology and Toxicology of Ibuprofen

Rainsford

2015

Ibuprofen

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Effect of ibuprofen dosage on patient response in rheumatoid arthritis

Godfrey

Cruz

1975

Arthritis & Rheumatism

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In a 4‐week double‐blind trial in 41 patients with rheumatoid arthritis, ibuprofen (Motrin®) decreased the swollen joint count significantly at a dosage level of 2400 mg/day, but not at 1200 mg/day. Ibuprofen probably does have antiinflammatory effects in man, but only at higher dosages; antiarthritic activity at lower dosages reflects primarily analgesia and perhaps antipyretic effects. Complaints and clinical laboratory findings did not differ significantly between the dosage groups.

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Double-Blind Comparison of Ibuprofen and Phenylbutazone in the Short-Term Treatment of Rheumatoid Arthritis

Cited by 7 publications

References 5 publications

Ibuprofen versus Buffered Phenylbutazone in the Treatment of Osteoarthritis: Double‐Blind Trial

Ibuprofen versus Buffered Phenylbutazone in the Treatment of Osteoarthritis: Double‐Blind Trial

Pharmacology and Toxicology of Ibuprofen

Effect of ibuprofen dosage on patient response in rheumatoid arthritis

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