Double-Blind Comparison of An Acetaminophen 400 mg-Codeine 25 mg Combination Versus Aspirin 1000 mg and Placebo in Acute Migraine Attack

Boureau, F.; Joubert, Jean-Michel; Lasserre, Virgine; Prum, Bruce E.; Delecoeuillerie, G

doi:10.1046/j.1468-2982.1994.1402156.x

Cited by 57 publications

(58 citation statements)

References 21 publications

(14 reference statements)

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“…There are very few trials of opiate medication in migraine; one study indicates that a combination of codeine 25 mg and paracetamol 1,000 mg is no better than aspirin. 25 Given the known risks of rapid habituation to opiates, and of developing rebound headache and medication overuse, the use of opiates for migraine should be a last resort when all other acute treatments are either ineffective or contraindicated.…”

Section: Acute Treatment Of Migrainementioning

confidence: 99%

Drug therapy in headache

Weatherall

2015

Clinical Medicine

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All physicians will encounter patients with headaches. Primary headache disorders are common, and often disabling. This paper reviews the principles of drug therapy in headache in adults, focusing on the three commonest disorders presenting in both primary and secondary care: tension-type headache, migraine and cluster headache. The clinical evidence on the basis of which choices can be made between the currently available drug therapies for acute and preventive treatment of these disorders is presented, and information given on the options available for the emergency parenteral treatment of refractory migraine attacks and cluster headache.

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Section: Acute Treatment Of Migrainementioning

confidence: 99%

Drug therapy in headache

Weatherall

2015

Clinical Medicine

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“…In its tablet form, aspirin is as effective as acetaminophen or acetaminophen plus codeine [30,Class I]. It appears that aspirin is most efficacious in its effervescent form and in combination with other medications such as the antiemetic metoclopramide [31, Class I; 32, Class IV].…”

Section: Anti-inflammatoriesmentioning

confidence: 99%

Symptomatic Treatment of Migraine: When to Use NSAIDs, Triptans, or Opiates

Taylor

Kaniecki

2010

Curr Treat Options Neurol

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Migraine is a biologic disorder of the brain characterized by a heterogeneous array of symptoms and episodes of disabling headache. By definition, such attacks last between 4 and 72 h without treatment, with the disability arising from a variety of factors including severe pain, gastrointestinal symptoms such as nausea or vomiting, and sensory sensitivities to light, noise, or odor. All these features may be exacerbated by stimulation, motion, or activity, often rendering the patient completely immobile. Although retreat and rest, coupled with local application of ice, may provide some measure of comfort, most of those with migraine hunt for therapeutic solutions. In designing acute headache treatment strategies, it is imperative for clinicians to recognize the variability between individuals in the frequency, intensity, and duration of attacks. Certain patients require more aggressive options. It is also crucial to identify the significant intra-individual variability of migraine; most patients describe an assortment of headaches of different intensities and time to disability. Less intense episodes, which patients often term sinus, tension, or regular headaches, usually represent milder versions of migraine, simplifying both diagnostic and therapeutic approaches. Evidence-based guidelines and clinical experience support the use of nonsteroidal anti-inflammatory drugs (NSAIDs) in the management of mild to moderate migraine attacks. Recommend migraine-specific agents (triptans and dihydroergotamine) when the attacks are more severe or have consistently failed to respond to the use of NSAIDs in the past. Encourage those with less frequent episodic migraine to use their acute agents at the earliest signs of headache. Advise those with frequent headache (>10 days per month) to limit acute treatments to only the most disabling episodes in order to avoid the "medication overuse" phenomenon. Consider rescue or back-up therapy. Do not use compounds containing butalbital or opiates (or place extreme limits on them), out of concern for progression to chronic migraine.

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“…The efficacy of Aspirin (1000 mg) and a combination of acetaminophen 400 mg and codeine 25 mg showed not significant differences in their activity [51]. At last, a possible role for a low dosage of Aspirin has been suggested in migraine prophylaxis [52].…”

Section: Aspirin and Migrainementioning

confidence: 99%

Aspirin and tension-type headache

Farinelli

Martelletti

2007

J Headache Pain

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Acetylsalicylic acid (ASA, Aspirin) is among the most used drugs worldwide. At present, Aspirin represents a quite versatile drug employed in the control of pain symptomatologies and in situations such as prevention of both ischaemic stroke and cardiovascular events. Aspirin causes inhibition of prostaglandin (PG) synthesis by inactivation of the cyclooxygenase (COX) enzyme. ASA constitutes the focus of new researches explaining more widely Aspirin's control of inflammation. The induction of the endogenous epimers lipoxins (Aspirin-triggered 15-epi-lipoxins, ATLs) represents one of the most recent achievements. This particular feature of Aspirin is not shared by other NSAIDs. ASA is well known as a headache medication, figuring as a possible treatment choice in tension-type headache but also in acute migraine attacks. Furthermore, a new Aspirin formulation with a greater rapidity of action has been introduced. In conclusion, little information exists on the subject and more studies are required.

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Double-Blind Comparison of An Acetaminophen 400 mg-Codeine 25 mg Combination Versus Aspirin 1000 mg and Placebo in Acute Migraine Attack

Cited by 57 publications

References 21 publications

Drug therapy in headache

Drug therapy in headache

Symptomatic Treatment of Migraine: When to Use NSAIDs, Triptans, or Opiates

Aspirin and tension-type headache

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